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Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation.

Abstract

INTRODUCTION

Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. Maternal diet influences milk DHA, whereas milk AA seems rather constant. We investigated milk AA, DHA and DHA/AA after supplementation of AA plus DHA, or DHA alone during pregnancy and lactation.

SUBJECTS AND METHODS

Women were supplemented with AA+DHA (220mg each/day), DHA (220mg/day) or placebo during pregnancy and lactation. Milk samples were collected at 2 (n=86) and 12 weeks (n=69) postpartum.

RESULTS

Supplementation of AA+DHA elevated milk AA (week 2, 14%; week 12, 23%) and DHA (43% and 52%) as compared to placebo. DHA tended to decrease milk AA and vice versa. Milk AA, DHA and DHA/AA decreased from 2 to 12 weeks postpartum.

CONCLUSIONS

Milk AA and in particular DHA are sensitive to maternal supplementation. It seems that maternal AA and notably DHA status decline with advancing lactation.

Authors+Show Affiliations

Pathology and Laboratory Medicine, UMCG, University Medical Center Groningen, The Netherlands. s.a.van.goor@lc.umcg.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19118992

Citation

van Goor, Saskia A., et al. "Human Milk Arachidonic Acid and Docosahexaenoic Acid Contents Increase Following Supplementation During Pregnancy and Lactation." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 80, no. 1, 2009, pp. 65-9.
van Goor SA, Dijck-Brouwer DA, Hadders-Algra M, et al. Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. Prostaglandins Leukot Essent Fatty Acids. 2009;80(1):65-9.
van Goor, S. A., Dijck-Brouwer, D. A., Hadders-Algra, M., Doornbos, B., Erwich, J. J., Schaafsma, A., & Muskiet, F. A. (2009). Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 80(1), pp. 65-9. doi:10.1016/j.plefa.2008.11.002.
van Goor SA, et al. Human Milk Arachidonic Acid and Docosahexaenoic Acid Contents Increase Following Supplementation During Pregnancy and Lactation. Prostaglandins Leukot Essent Fatty Acids. 2009;80(1):65-9. PubMed PMID: 19118992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. AU - van Goor,Saskia A, AU - Dijck-Brouwer,D A Janneke, AU - Hadders-Algra,Mijna, AU - Doornbos,Bennard, AU - Erwich,Jan Jaap H M, AU - Schaafsma,Anne, AU - Muskiet,Frits A J, Y1 - 2008/12/31/ PY - 2008/06/03/received PY - 2008/11/03/revised PY - 2008/11/07/accepted PY - 2009/1/3/entrez PY - 2009/1/3/pubmed PY - 2009/4/18/medline SP - 65 EP - 9 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 80 IS - 1 N2 - INTRODUCTION: Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. Maternal diet influences milk DHA, whereas milk AA seems rather constant. We investigated milk AA, DHA and DHA/AA after supplementation of AA plus DHA, or DHA alone during pregnancy and lactation. SUBJECTS AND METHODS: Women were supplemented with AA+DHA (220mg each/day), DHA (220mg/day) or placebo during pregnancy and lactation. Milk samples were collected at 2 (n=86) and 12 weeks (n=69) postpartum. RESULTS: Supplementation of AA+DHA elevated milk AA (week 2, 14%; week 12, 23%) and DHA (43% and 52%) as compared to placebo. DHA tended to decrease milk AA and vice versa. Milk AA, DHA and DHA/AA decreased from 2 to 12 weeks postpartum. CONCLUSIONS: Milk AA and in particular DHA are sensitive to maternal supplementation. It seems that maternal AA and notably DHA status decline with advancing lactation. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/19118992/Human_milk_arachidonic_acid_and_docosahexaenoic_acid_contents_increase_following_supplementation_during_pregnancy_and_lactation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(08)00169-5 DB - PRIME DP - Unbound Medicine ER -