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Neural tube defects: prevalence, etiology and prevention.
Int J Urol. 2009 Jan; 16(1):49-57.IJ

Abstract

Spina bifida and anencephaly, the common form of neural tube defects, affect approximately 300 000 newborns each year worldwide. The effectiveness of folic acid supplementation in preventing their occurrence or recurrence has been unambiguous since 1991. In general, the prevalence of these abnormalities has decreased in the past 20 to 30 years because of periconceptional folate supplementation, food fortification in several countries, avoiding exposure to environmental factors, and increased accuracy of prenatal screening for fetal anomalies. Women who are planning to conceive should be informed about the importance of folic acid in fetal development and advised to take 400 microg/day of folic acid supplements. Food fortification with folic acid will ultimately be necessary to reduce the number of patients. Primary prevention of neural tube defects by the periconceptional intake of folic acid is a major public health opportunity and has wide implications in reducing the mortality and morbidity of offspring.

Authors+Show Affiliations

Department of Urology, Tsushima Rehabilitation Hospital, Tsushima, Aichi, Japan. akondo@fj8.so-net.ne.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19120526

Citation

Kondo, Atsuo, et al. "Neural Tube Defects: Prevalence, Etiology and Prevention." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 16, no. 1, 2009, pp. 49-57.
Kondo A, Kamihira O, Ozawa H. Neural tube defects: prevalence, etiology and prevention. Int J Urol. 2009;16(1):49-57.
Kondo, A., Kamihira, O., & Ozawa, H. (2009). Neural tube defects: prevalence, etiology and prevention. International Journal of Urology : Official Journal of the Japanese Urological Association, 16(1), 49-57. https://doi.org/10.1111/j.1442-2042.2008.02163.x
Kondo A, Kamihira O, Ozawa H. Neural Tube Defects: Prevalence, Etiology and Prevention. Int J Urol. 2009;16(1):49-57. PubMed PMID: 19120526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural tube defects: prevalence, etiology and prevention. AU - Kondo,Atsuo, AU - Kamihira,Osamu, AU - Ozawa,Hideo, PY - 2009/1/6/entrez PY - 2009/1/6/pubmed PY - 2009/4/8/medline SP - 49 EP - 57 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int. J. Urol. VL - 16 IS - 1 N2 - Spina bifida and anencephaly, the common form of neural tube defects, affect approximately 300 000 newborns each year worldwide. The effectiveness of folic acid supplementation in preventing their occurrence or recurrence has been unambiguous since 1991. In general, the prevalence of these abnormalities has decreased in the past 20 to 30 years because of periconceptional folate supplementation, food fortification in several countries, avoiding exposure to environmental factors, and increased accuracy of prenatal screening for fetal anomalies. Women who are planning to conceive should be informed about the importance of folic acid in fetal development and advised to take 400 microg/day of folic acid supplements. Food fortification with folic acid will ultimately be necessary to reduce the number of patients. Primary prevention of neural tube defects by the periconceptional intake of folic acid is a major public health opportunity and has wide implications in reducing the mortality and morbidity of offspring. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/19120526/Neural_tube_defects:_prevalence_etiology_and_prevention_ L2 - https://doi.org/10.1111/j.1442-2042.2008.02163.x DB - PRIME DP - Unbound Medicine ER -