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Seropositivity to Burkholderia pseudomallei does not reflect the development of cell-mediated immunity.
Trans R Soc Trop Med Hyg. 2008 Dec; 102 Suppl 1:S66-70.TR

Abstract

Cell-mediated immunity to Burkholderia pseudomallei, the causative agent of melioidosis, provides protection from disease progression. An indirect haemagglutination assay was used to detect antibodies to B. pseudomallei in 1500 healthy donors in an endemic region of Australia. Lymphocyte proliferation, activation and cytokine expression to B. pseudomallei antigen were determined in eight donors who were seropositive and in eight age- and sex-matched controls. In North Queensland, 2.5% of the population was seropositive for B. pseudomallei, which is less than half that which was previously described. Of clinical significance was the observation that while 75% of the seropositive individuals had increased lymphocyte proliferation to B. pseudomallei antigens, there were no significant differences observed in lymphocyte activation or production of cytokines.

Authors+Show Affiliations

School of Veterinary and Biomedical Sciences, James Cook University, Queensland 4811, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19121692

Citation

Lazzaroni, Sharon M., et al. "Seropositivity to Burkholderia Pseudomallei Does Not Reflect the Development of Cell-mediated Immunity." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 102 Suppl 1, 2008, pp. S66-70.
Lazzaroni SM, Barnes JL, Williams NL, et al. Seropositivity to Burkholderia pseudomallei does not reflect the development of cell-mediated immunity. Trans R Soc Trop Med Hyg. 2008;102 Suppl 1:S66-70.
Lazzaroni, S. M., Barnes, J. L., Williams, N. L., Govan, B. L., Norton, R. E., LaBrooy, J. T., & Ketheesan, N. (2008). Seropositivity to Burkholderia pseudomallei does not reflect the development of cell-mediated immunity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 Suppl 1, S66-70. https://doi.org/10.1016/S0035-9203(08)70018-X
Lazzaroni SM, et al. Seropositivity to Burkholderia Pseudomallei Does Not Reflect the Development of Cell-mediated Immunity. Trans R Soc Trop Med Hyg. 2008;102 Suppl 1:S66-70. PubMed PMID: 19121692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seropositivity to Burkholderia pseudomallei does not reflect the development of cell-mediated immunity. AU - Lazzaroni,Sharon M, AU - Barnes,Jodie L, AU - Williams,Natasha L, AU - Govan,Brenda L, AU - Norton,Robert E, AU - LaBrooy,Justin T, AU - Ketheesan,Natkunam, PY - 2009/1/6/entrez PY - 2009/1/16/pubmed PY - 2009/11/11/medline SP - S66 EP - 70 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 102 Suppl 1 N2 - Cell-mediated immunity to Burkholderia pseudomallei, the causative agent of melioidosis, provides protection from disease progression. An indirect haemagglutination assay was used to detect antibodies to B. pseudomallei in 1500 healthy donors in an endemic region of Australia. Lymphocyte proliferation, activation and cytokine expression to B. pseudomallei antigen were determined in eight donors who were seropositive and in eight age- and sex-matched controls. In North Queensland, 2.5% of the population was seropositive for B. pseudomallei, which is less than half that which was previously described. Of clinical significance was the observation that while 75% of the seropositive individuals had increased lymphocyte proliferation to B. pseudomallei antigens, there were no significant differences observed in lymphocyte activation or production of cytokines. SN - 1878-3503 UR - https://www.unboundmedicine.com/medline/citation/19121692/Seropositivity_to_Burkholderia_pseudomallei_does_not_reflect_the_development_of_cell_mediated_immunity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(08)70018-X DB - PRIME DP - Unbound Medicine ER -