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Combined effects of saturated fat and cholesterol intakes on serum lipids: Tehran Lipid and Glucose Study.
Nutrition. 2009 May; 25(5):526-31.N

Abstract

OBJECTIVE

This study investigated the combined effect of saturated fat and cholesterol intake on serum lipids among Tehranian adults.

METHODS

In 443 subjects >or=18 y, dietary intake was assessed. Height and weight were measured and body mass index was calculated. Serum cholesterol, triacylglycerol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were calculated. Cholesterol intakes >or=300 mg/d and saturated fat intakes >or=7% of total energy were defined as high intakes. Individuals were categorized into four groups based on cholesterol and saturated fat intakes.

RESULTS

Subjects' mean age was 40.1 +/- 14.6 y; those in whom cholesterol and saturated fat intake was normal had significantly less energy and fat intake than those with high cholesterol and saturated fat intakes (P < 0.01). Saturated fat intake had a significant effect on serum total and HDL-C levels. Subjects with a normal saturated fat intake had significantly less serum total and HDL-C than those who had high saturated fat intake (P < 0.01 and P < 0.05, respectively). Adjusting for age, sex, and body mass index, the main effect of cholesterol intake on HDL-C was significant (P = 0.05). Mean serum HDL-C was lower in subjects who had normal cholesterol intake than in those with high cholesterol intake.

CONCLUSION

These results show that cholesterol and saturated fat intakes have no combined effect on serum low-density lipoprotein cholesterol level, whereas cholesterol intake per se affects serum HDL-C level.

Authors+Show Affiliations

Obesity Research Center, Research Institute of Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. mirmiran@endocrine.ac.irNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19121920

Citation

Mirmiran, Parvin, et al. "Combined Effects of Saturated Fat and Cholesterol Intakes On Serum Lipids: Tehran Lipid and Glucose Study." Nutrition (Burbank, Los Angeles County, Calif.), vol. 25, no. 5, 2009, pp. 526-31.
Mirmiran P, Ramezankhani A, Azizi F. Combined effects of saturated fat and cholesterol intakes on serum lipids: Tehran Lipid and Glucose Study. Nutrition. 2009;25(5):526-31.
Mirmiran, P., Ramezankhani, A., & Azizi, F. (2009). Combined effects of saturated fat and cholesterol intakes on serum lipids: Tehran Lipid and Glucose Study. Nutrition (Burbank, Los Angeles County, Calif.), 25(5), 526-31. https://doi.org/10.1016/j.nut.2008.11.018
Mirmiran P, Ramezankhani A, Azizi F. Combined Effects of Saturated Fat and Cholesterol Intakes On Serum Lipids: Tehran Lipid and Glucose Study. Nutrition. 2009;25(5):526-31. PubMed PMID: 19121920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effects of saturated fat and cholesterol intakes on serum lipids: Tehran Lipid and Glucose Study. AU - Mirmiran,Parvin, AU - Ramezankhani,Azra, AU - Azizi,Fereidoun, Y1 - 2009/01/03/ PY - 2008/08/04/received PY - 2008/10/22/revised PY - 2008/11/08/accepted PY - 2009/1/6/entrez PY - 2009/1/6/pubmed PY - 2009/6/26/medline SP - 526 EP - 31 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 25 IS - 5 N2 - OBJECTIVE: This study investigated the combined effect of saturated fat and cholesterol intake on serum lipids among Tehranian adults. METHODS: In 443 subjects >or=18 y, dietary intake was assessed. Height and weight were measured and body mass index was calculated. Serum cholesterol, triacylglycerol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were calculated. Cholesterol intakes >or=300 mg/d and saturated fat intakes >or=7% of total energy were defined as high intakes. Individuals were categorized into four groups based on cholesterol and saturated fat intakes. RESULTS: Subjects' mean age was 40.1 +/- 14.6 y; those in whom cholesterol and saturated fat intake was normal had significantly less energy and fat intake than those with high cholesterol and saturated fat intakes (P < 0.01). Saturated fat intake had a significant effect on serum total and HDL-C levels. Subjects with a normal saturated fat intake had significantly less serum total and HDL-C than those who had high saturated fat intake (P < 0.01 and P < 0.05, respectively). Adjusting for age, sex, and body mass index, the main effect of cholesterol intake on HDL-C was significant (P = 0.05). Mean serum HDL-C was lower in subjects who had normal cholesterol intake than in those with high cholesterol intake. CONCLUSION: These results show that cholesterol and saturated fat intakes have no combined effect on serum low-density lipoprotein cholesterol level, whereas cholesterol intake per se affects serum HDL-C level. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19121920/Combined_effects_of_saturated_fat_and_cholesterol_intakes_on_serum_lipids:_Tehran_Lipid_and_Glucose_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00492-9 DB - PRIME DP - Unbound Medicine ER -