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Prevalence of coronary artery disease and coronary risk factors in an urban population of Tirupati.
Indian Heart J. 2007 Mar-Apr; 59(2):157-64.IH

Abstract

AIMS AND OBJECTIVES

To determine the prevalence of coronary heart disease and its risk factors in the urban population of Tirupati.

METHODS

The urban population of Tirupati is spread into 20 wards. Thirteen wards were selected randomly and systematic random sampling was done to identify the sampling unit household. A total of 1519 subjects (539 males and 980 females) 20 years of age formed the sample of the study. Demographic (age, sex, occupation, education and income), behavioral (smoking), anthropometric (height, weight, waist and hip circumferences) and physiological (blood pressure) parameters were noted and recorded and biochemical parameters (serum glucose, total cholesterol, triglycerides, HDL cholesterol levels) were assayed. Coronary artery disease was diagnosed based on history and ECG changes suggestive of ST-segment depression (Minnesota 4-1 to 4-2) or Q wave changes (Minnesota codes 1-1-1 to 1-1-7) or T wave changes (Minnesota codes 5-1 to 5-3).

RESULTS

The overall prevalence in the study population was 12.63 (192 cases). In males it was 6.86 (37 cases) and in females 15.81 (155 cases). The major risk factors in this population were central obesity 1003 (66%) [male 320 (59.4%) and females 683 (41.12%)], low HDL cholesterol 709 (46.67%) [male 284 (52.69%) and females 425 (43.36%)], obesity 588 (38.07%) [males 187 (34.32%) and females 403 (41.12%)], high triglyceride levels (>or= 150 mg/dl) 444 (29.22%)[(males 173 (32.09%) and females 272 (27.75%)], high cholesterol levels (>or= 200mg/dl) [(males 127 (23.56%) and females 278 (28.36%)] and hypertension 396 (26.06) [(males 149 (27.64%) and females 247 (25.20%)]. Around a fraction of subjects had metabolic syndrome 371 (24.42%) [(males 90 (16.69%) and females 281 (28.64%)]. In multivariate regression analysis, age (OR 1.05 95% CI 1.01-1.09 p<0.01) and high serum LDL cholesterol level (OR 4.62 95% CI 2.29-9.32 p<0.001) in males and serum triglycerides (OR 1.003 95% CI 1.000-1.005) in females were associated with CAD.

CONCLUSIONS

Association of age, high LDL cholesterol in males and triglycerides in females with CAD shows the importance of these risk factors in this population. This was only a cross-sectional study done at one point of time. Clinical importance of these risk factors needs to be tested in the longitudinal study.

Authors+Show Affiliations

Department of Cardiology, Sri Venkateswara Institute of Medical Sciences, Tirupati.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19122250

Citation

Latheef, S A A., and G Subramanyam. "Prevalence of Coronary Artery Disease and Coronary Risk Factors in an Urban Population of Tirupati." Indian Heart Journal, vol. 59, no. 2, 2007, pp. 157-64.
Latheef SA, Subramanyam G. Prevalence of coronary artery disease and coronary risk factors in an urban population of Tirupati. Indian Heart J. 2007;59(2):157-64.
Latheef, S. A., & Subramanyam, G. (2007). Prevalence of coronary artery disease and coronary risk factors in an urban population of Tirupati. Indian Heart Journal, 59(2), 157-64.
Latheef SA, Subramanyam G. Prevalence of Coronary Artery Disease and Coronary Risk Factors in an Urban Population of Tirupati. Indian Heart J. 2007 Mar-Apr;59(2):157-64. PubMed PMID: 19122250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of coronary artery disease and coronary risk factors in an urban population of Tirupati. AU - Latheef,S A A, AU - Subramanyam,G, PY - 2009/1/6/entrez PY - 2007/3/1/pubmed PY - 2009/2/20/medline SP - 157 EP - 64 JF - Indian heart journal JO - Indian Heart J VL - 59 IS - 2 N2 - AIMS AND OBJECTIVES: To determine the prevalence of coronary heart disease and its risk factors in the urban population of Tirupati. METHODS: The urban population of Tirupati is spread into 20 wards. Thirteen wards were selected randomly and systematic random sampling was done to identify the sampling unit household. A total of 1519 subjects (539 males and 980 females) 20 years of age formed the sample of the study. Demographic (age, sex, occupation, education and income), behavioral (smoking), anthropometric (height, weight, waist and hip circumferences) and physiological (blood pressure) parameters were noted and recorded and biochemical parameters (serum glucose, total cholesterol, triglycerides, HDL cholesterol levels) were assayed. Coronary artery disease was diagnosed based on history and ECG changes suggestive of ST-segment depression (Minnesota 4-1 to 4-2) or Q wave changes (Minnesota codes 1-1-1 to 1-1-7) or T wave changes (Minnesota codes 5-1 to 5-3). RESULTS: The overall prevalence in the study population was 12.63 (192 cases). In males it was 6.86 (37 cases) and in females 15.81 (155 cases). The major risk factors in this population were central obesity 1003 (66%) [male 320 (59.4%) and females 683 (41.12%)], low HDL cholesterol 709 (46.67%) [male 284 (52.69%) and females 425 (43.36%)], obesity 588 (38.07%) [males 187 (34.32%) and females 403 (41.12%)], high triglyceride levels (>or= 150 mg/dl) 444 (29.22%)[(males 173 (32.09%) and females 272 (27.75%)], high cholesterol levels (>or= 200mg/dl) [(males 127 (23.56%) and females 278 (28.36%)] and hypertension 396 (26.06) [(males 149 (27.64%) and females 247 (25.20%)]. Around a fraction of subjects had metabolic syndrome 371 (24.42%) [(males 90 (16.69%) and females 281 (28.64%)]. In multivariate regression analysis, age (OR 1.05 95% CI 1.01-1.09 p<0.01) and high serum LDL cholesterol level (OR 4.62 95% CI 2.29-9.32 p<0.001) in males and serum triglycerides (OR 1.003 95% CI 1.000-1.005) in females were associated with CAD. CONCLUSIONS: Association of age, high LDL cholesterol in males and triglycerides in females with CAD shows the importance of these risk factors in this population. This was only a cross-sectional study done at one point of time. Clinical importance of these risk factors needs to be tested in the longitudinal study. SN - 0019-4832 UR - https://www.unboundmedicine.com/medline/citation/19122250/Prevalence_of_coronary_artery_disease_and_coronary_risk_factors_in_an_urban_population_of_Tirupati_ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -