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Retrospective serological study on sequential dengue virus serotypes 1 to 4 epidemics in Tainan City, Taiwan, 1994 to 2000.
J Microbiol Immunol Infect. 2008 Oct; 41(5):377-85.JM

Abstract

BACKGROUND AND PURPOSE

We previously reported the development of a non-structural protein NS1 serotype-specific immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) for dengue serodiagnosis and seroepidemiological study. This assay can be used to differentiate the immunologic status of individuals into naive, primary, or secondary dengue virus (DENV) infection and identify the DENV serotypes of primary infection. A retrospective study was conducted to investigate the serological responses of confirmed dengue cases infected during each of the sequential DENV-1 (August 1994 to February 1995), DENV-2 (August to December 1997), DENV-3 (August 1998 to January 1999), and DENV-4 (June to December 2000) epidemics in Tainan City, Taiwan.

METHODS

218 serum samples collected 1.1 to 7.2 years postinfection were analyzed by NS1 serotype-specific IgG ELISA together with corresponding acute and/or convalescent serum samples when available. The immunological status and the infecting DENV serotypes were determined for these individuals.

RESULTS

High titers of dengue NS1 serotype-specific IgG antibody could be detected in serum samples. Differentiation of immunological status showed that 76.6% and 23.4% of cases had primary and secondary infections, respectively. A significant age-dependent increase in the rate of secondary infection was observed for those cases born before 1942. Notably, analysis of postinfection serum samples of 17 dengue hemorrhagic fever patients infected during the 1998 DENV-3 epidemic showed that 9 cases (53%) had primary infections.

CONCLUSIONS

Our data revealed that a majority of the population born after 1943 in Tainan City are naive to DENV infection and are at high risk of infection with all 4 DENV serotypes.

Authors+Show Affiliations

Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19122918

Citation

Chang, Shu-Fen, et al. "Retrospective Serological Study On Sequential Dengue Virus Serotypes 1 to 4 Epidemics in Tainan City, Taiwan, 1994 to 2000." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 41, no. 5, 2008, pp. 377-85.
Chang SF, Huang JH, Chen LK, et al. Retrospective serological study on sequential dengue virus serotypes 1 to 4 epidemics in Tainan City, Taiwan, 1994 to 2000. J Microbiol Immunol Infect. 2008;41(5):377-85.
Chang, S. F., Huang, J. H., Chen, L. K., Su, C. L., Liao, T. L., Chien, L. J., Lin, T. H., Su, C. J., & Shu, P. Y. (2008). Retrospective serological study on sequential dengue virus serotypes 1 to 4 epidemics in Tainan City, Taiwan, 1994 to 2000. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 41(5), 377-85.
Chang SF, et al. Retrospective Serological Study On Sequential Dengue Virus Serotypes 1 to 4 Epidemics in Tainan City, Taiwan, 1994 to 2000. J Microbiol Immunol Infect. 2008;41(5):377-85. PubMed PMID: 19122918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective serological study on sequential dengue virus serotypes 1 to 4 epidemics in Tainan City, Taiwan, 1994 to 2000. AU - Chang,Shu-Fen, AU - Huang,Jyh-Hsiung, AU - Chen,Li-Kuang, AU - Su,Chien-Ling, AU - Liao,Tsai-Ling, AU - Chien,Li-Jung, AU - Lin,Ting-Hsiang, AU - Su,Chun-Jen, AU - Shu,Pei-Yun, PY - 2009/1/6/entrez PY - 2009/1/6/pubmed PY - 2009/8/15/medline SP - 377 EP - 85 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 41 IS - 5 N2 - BACKGROUND AND PURPOSE: We previously reported the development of a non-structural protein NS1 serotype-specific immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) for dengue serodiagnosis and seroepidemiological study. This assay can be used to differentiate the immunologic status of individuals into naive, primary, or secondary dengue virus (DENV) infection and identify the DENV serotypes of primary infection. A retrospective study was conducted to investigate the serological responses of confirmed dengue cases infected during each of the sequential DENV-1 (August 1994 to February 1995), DENV-2 (August to December 1997), DENV-3 (August 1998 to January 1999), and DENV-4 (June to December 2000) epidemics in Tainan City, Taiwan. METHODS: 218 serum samples collected 1.1 to 7.2 years postinfection were analyzed by NS1 serotype-specific IgG ELISA together with corresponding acute and/or convalescent serum samples when available. The immunological status and the infecting DENV serotypes were determined for these individuals. RESULTS: High titers of dengue NS1 serotype-specific IgG antibody could be detected in serum samples. Differentiation of immunological status showed that 76.6% and 23.4% of cases had primary and secondary infections, respectively. A significant age-dependent increase in the rate of secondary infection was observed for those cases born before 1942. Notably, analysis of postinfection serum samples of 17 dengue hemorrhagic fever patients infected during the 1998 DENV-3 epidemic showed that 9 cases (53%) had primary infections. CONCLUSIONS: Our data revealed that a majority of the population born after 1943 in Tainan City are naive to DENV infection and are at high risk of infection with all 4 DENV serotypes. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/19122918/Retrospective_serological_study_on_sequential_dengue_virus_serotypes_1_to_4_epidemics_in_Tainan_City_Taiwan_1994_to_2000_ L2 - https://medlineplus.gov/dengue.html DB - PRIME DP - Unbound Medicine ER -