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Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors.
Hippocampus. 2009 Aug; 19(8):706-17.H

Abstract

Changes in hippocampal synaptic networks during aging may contribute to age-dependent compromise of cognitive functions such as learning and memory. Previous studies have demonstrated that GABAergic synaptic transmission exhibits age-dependent changes. To better understand such age-dependent changes of GABAergic synaptic inhibition, we performed whole-cell recordings from pyramidal cells in the CA1 area of acute hippocampal slices on aged (24-26 months old) and young (2-4 months old) Brown-Norway rats. We found that the frequency and amplitude of spontaneous inhibitory postsynaptic current (IPSCs) were significantly increased in aged rats, but the frequency and amplitude of mIPSCs were decreased. Furthermore, the regulation of GABAergic synaptic transmission by GluR5 containing kainate receptors was enhanced in aged rats, which was revealed by using LY382884 (a GluR5 kainate receptor antagonist) and ATPA (a GluR5 kainate receptor agonist). Moreover, we demonstrated that vesicular glutamate transporters are involved in the kainate receptor dependent regulation of sIPSCs. Taken together, these results suggest that GABAergic synaptic transmission is potentiated in aged rats, and GluR5 containing kainate receptors regulate the inhibitory synaptic transmission through endogenous glutamate. These alterations of GABAergic input with aging could contribute to age-dependent cognitive decline.

Authors+Show Affiliations

Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850-3332, USA. changqing@brni-jhu.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19123252

Citation

Xu, Changqing, et al. "Age-dependent Enhancement of Inhibitory Synaptic Transmission in CA1 Pyramidal Neurons Via GluR5 Kainate Receptors." Hippocampus, vol. 19, no. 8, 2009, pp. 706-17.
Xu C, Cui C, Alkon DL. Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors. Hippocampus. 2009;19(8):706-17.
Xu, C., Cui, C., & Alkon, D. L. (2009). Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors. Hippocampus, 19(8), 706-17. https://doi.org/10.1002/hipo.20544
Xu C, Cui C, Alkon DL. Age-dependent Enhancement of Inhibitory Synaptic Transmission in CA1 Pyramidal Neurons Via GluR5 Kainate Receptors. Hippocampus. 2009;19(8):706-17. PubMed PMID: 19123252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors. AU - Xu,Changqing, AU - Cui,Changhai, AU - Alkon,Daniel L, PY - 2009/1/6/entrez PY - 2009/1/6/pubmed PY - 2009/10/10/medline SP - 706 EP - 17 JF - Hippocampus JO - Hippocampus VL - 19 IS - 8 N2 - Changes in hippocampal synaptic networks during aging may contribute to age-dependent compromise of cognitive functions such as learning and memory. Previous studies have demonstrated that GABAergic synaptic transmission exhibits age-dependent changes. To better understand such age-dependent changes of GABAergic synaptic inhibition, we performed whole-cell recordings from pyramidal cells in the CA1 area of acute hippocampal slices on aged (24-26 months old) and young (2-4 months old) Brown-Norway rats. We found that the frequency and amplitude of spontaneous inhibitory postsynaptic current (IPSCs) were significantly increased in aged rats, but the frequency and amplitude of mIPSCs were decreased. Furthermore, the regulation of GABAergic synaptic transmission by GluR5 containing kainate receptors was enhanced in aged rats, which was revealed by using LY382884 (a GluR5 kainate receptor antagonist) and ATPA (a GluR5 kainate receptor agonist). Moreover, we demonstrated that vesicular glutamate transporters are involved in the kainate receptor dependent regulation of sIPSCs. Taken together, these results suggest that GABAergic synaptic transmission is potentiated in aged rats, and GluR5 containing kainate receptors regulate the inhibitory synaptic transmission through endogenous glutamate. These alterations of GABAergic input with aging could contribute to age-dependent cognitive decline. SN - 1098-1063 UR - https://www.unboundmedicine.com/medline/citation/19123252/Age_dependent_enhancement_of_inhibitory_synaptic_transmission_in_CA1_pyramidal_neurons_via_GluR5_kainate_receptors_ L2 - https://doi.org/10.1002/hipo.20544 DB - PRIME DP - Unbound Medicine ER -