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Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure.
Arch Gynecol Obstet. 2009 Aug; 280(2):255-61.AG

Abstract

OBJECTIVE

The aim of this study is to compare the effect of ethinyl estradiol 0.03 mg/gestodene 0.075 mg (EE/GSD) with ethinylestradiol 0.03 mg/drospirenone 3 mg (EE/DRSP) administered according to conventional 21/7 regimen on body mass index (BMI), blood pressure (BP), lipid metabolism and hemostatic parameters.

METHOD

In this study, 160 healthy women were randomized to EE/GSD mg or EE/DRSP for 12 months. Mean differences in BMI, high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) levels and BP compared to baseline were assessed.

RESULTS

One hundred and forty-five (89%) of the women completed all 12 treatment cycles. The subjects randomly assigned into two treatment groups. Group EE/GSD (n = 71) and group EE/DRSP (n = 72). In group B, BMI values were significantly lower than baseline at the sixth cycle. DRSP/EE had more favorable effects on BP than GSD/EE with the mean systolic and diastolic BPs remaining lower in the DRSP/EE group. The difference between the two preparations was not statistically significant at the end of the study. TC levels remained similar in both groups throughout the study period. In both groups LDL-C levels decreased, triglyceride and HDL-C levels significantly increased from baseline levels. These changes result in increasing HDL-C/LDL-C ratio, demonstrating anti-atherogenic effect. Menstrual cycle patterns and the incidence of adverse events were similar between groups. The duration of withdrawal bleeding decreased during the study for both groups and was similar.

CONCLUSION

The EE/DRSP regimen provides good cycle control with reliable contraceptive efficacy and low incidence of adverse events. Compared with the EE/GSD preparation, the EE/DRSP preparation demonstrated a more favorable effect on BMI and BP with the mean BMI and mean BP remaining lower than baseline mean. The new formulation may be especially beneficial for women susceptible to body weight gain and rise in BP.

Authors+Show Affiliations

Department of Obstetric and Gynecology, School of Medicine, Yuzuncu Yil University, Van, Turkey. recepyildizhan@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19125264

Citation

Yildizhan, Recep, et al. "Effects of Two Combined Oral Contraceptives Containing Ethinyl Estradiol 30 Microg Combined With Either Gestodene or Drospirenone On Hemostatic Parameters, Lipid Profiles and Blood Pressure." Archives of Gynecology and Obstetrics, vol. 280, no. 2, 2009, pp. 255-61.
Yildizhan R, Yildizhan B, Adali E, et al. Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure. Arch Gynecol Obstet. 2009;280(2):255-61.
Yildizhan, R., Yildizhan, B., Adali, E., Yoruk, P., Birol, F., & Suer, N. (2009). Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure. Archives of Gynecology and Obstetrics, 280(2), 255-61. https://doi.org/10.1007/s00404-008-0907-x
Yildizhan R, et al. Effects of Two Combined Oral Contraceptives Containing Ethinyl Estradiol 30 Microg Combined With Either Gestodene or Drospirenone On Hemostatic Parameters, Lipid Profiles and Blood Pressure. Arch Gynecol Obstet. 2009;280(2):255-61. PubMed PMID: 19125264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure. AU - Yildizhan,Recep, AU - Yildizhan,Begum, AU - Adali,Ertan, AU - Yoruk,Pinar, AU - Birol,Fatih, AU - Suer,Necdet, Y1 - 2009/01/06/ PY - 2008/09/11/received PY - 2008/12/19/accepted PY - 2009/1/7/entrez PY - 2009/1/7/pubmed PY - 2009/9/25/medline SP - 255 EP - 61 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 280 IS - 2 N2 - OBJECTIVE: The aim of this study is to compare the effect of ethinyl estradiol 0.03 mg/gestodene 0.075 mg (EE/GSD) with ethinylestradiol 0.03 mg/drospirenone 3 mg (EE/DRSP) administered according to conventional 21/7 regimen on body mass index (BMI), blood pressure (BP), lipid metabolism and hemostatic parameters. METHOD: In this study, 160 healthy women were randomized to EE/GSD mg or EE/DRSP for 12 months. Mean differences in BMI, high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) levels and BP compared to baseline were assessed. RESULTS: One hundred and forty-five (89%) of the women completed all 12 treatment cycles. The subjects randomly assigned into two treatment groups. Group EE/GSD (n = 71) and group EE/DRSP (n = 72). In group B, BMI values were significantly lower than baseline at the sixth cycle. DRSP/EE had more favorable effects on BP than GSD/EE with the mean systolic and diastolic BPs remaining lower in the DRSP/EE group. The difference between the two preparations was not statistically significant at the end of the study. TC levels remained similar in both groups throughout the study period. In both groups LDL-C levels decreased, triglyceride and HDL-C levels significantly increased from baseline levels. These changes result in increasing HDL-C/LDL-C ratio, demonstrating anti-atherogenic effect. Menstrual cycle patterns and the incidence of adverse events were similar between groups. The duration of withdrawal bleeding decreased during the study for both groups and was similar. CONCLUSION: The EE/DRSP regimen provides good cycle control with reliable contraceptive efficacy and low incidence of adverse events. Compared with the EE/GSD preparation, the EE/DRSP preparation demonstrated a more favorable effect on BMI and BP with the mean BMI and mean BP remaining lower than baseline mean. The new formulation may be especially beneficial for women susceptible to body weight gain and rise in BP. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/19125264/Effects_of_two_combined_oral_contraceptives_containing_ethinyl_estradiol_30_microg_combined_with_either_gestodene_or_drospirenone_on_hemostatic_parameters_lipid_profiles_and_blood_pressure_ L2 - https://dx.doi.org/10.1007/s00404-008-0907-x DB - PRIME DP - Unbound Medicine ER -