Tags

Type your tag names separated by a space and hit enter

Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS).
Clin Hemorheol Microcirc. 2008; 40(4):303-9.CH

Abstract

Sickle cell disease is characterized by altered blood rheology due to a reduced haematocrit and a resulting lowered viscosity. Oxygen carriage, and consequently oxygen delivery, may be deleteriously affected if the haematocrit reduction is such as to limit oxygen uptake from the lungs and delivery to the tissues. The present study seeks to determine and compare the oxygen delivery index (ODI) in subjects with normal and abnormal haemoglobin genotypes. Thirty four apparently healthy subjects having normal haemoglobin genotype (AA), 27 with sickle cell trait (AS) and 50 with homozygous sickle cell disease (SS) were recruited into the study. Whole blood viscosity was measured at low and high shear rates of 23 s(-1) and 230 s(-1), respectively, using a Wells Brookfield Cone and Plate Viscometer. Haematocrit was determined using an AC.Tron Coulter Counter. The oxygen delivery index was calculated as the ratio of the haematocrit to whole blood viscosity. There was a statistically significant difference in the ODI in the SS group compared with both the AA and AS groups. There was no statistical significance in the ODI between the AA and AS groups. The ODI may be considered as a useful assessment of oxygen delivery in subjects with sickle cell disease.

Authors+Show Affiliations

Department of Basic Medical Sciences, Physiology Section, Faculty of Medical Sciences, University of the West Indies, Jamaica, West Indies.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19126993

Citation

Bowers, A S., et al. "Oxygen Delivery Index in Subjects With Normal Haemoglobin (HbAA), Sickle Cell Trait (HbAS) and Homozygous Sickle Cell Disease (HbSS)." Clinical Hemorheology and Microcirculation, vol. 40, no. 4, 2008, pp. 303-9.
Bowers AS, Pepple DJ, Reid HL. Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS). Clin Hemorheol Microcirc. 2008;40(4):303-9.
Bowers, A. S., Pepple, D. J., & Reid, H. L. (2008). Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS). Clinical Hemorheology and Microcirculation, 40(4), 303-9.
Bowers AS, Pepple DJ, Reid HL. Oxygen Delivery Index in Subjects With Normal Haemoglobin (HbAA), Sickle Cell Trait (HbAS) and Homozygous Sickle Cell Disease (HbSS). Clin Hemorheol Microcirc. 2008;40(4):303-9. PubMed PMID: 19126993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS). AU - Bowers,A S, AU - Pepple,D J, AU - Reid,H L, PY - 2009/1/8/entrez PY - 2009/1/8/pubmed PY - 2009/3/27/medline SP - 303 EP - 9 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 40 IS - 4 N2 - Sickle cell disease is characterized by altered blood rheology due to a reduced haematocrit and a resulting lowered viscosity. Oxygen carriage, and consequently oxygen delivery, may be deleteriously affected if the haematocrit reduction is such as to limit oxygen uptake from the lungs and delivery to the tissues. The present study seeks to determine and compare the oxygen delivery index (ODI) in subjects with normal and abnormal haemoglobin genotypes. Thirty four apparently healthy subjects having normal haemoglobin genotype (AA), 27 with sickle cell trait (AS) and 50 with homozygous sickle cell disease (SS) were recruited into the study. Whole blood viscosity was measured at low and high shear rates of 23 s(-1) and 230 s(-1), respectively, using a Wells Brookfield Cone and Plate Viscometer. Haematocrit was determined using an AC.Tron Coulter Counter. The oxygen delivery index was calculated as the ratio of the haematocrit to whole blood viscosity. There was a statistically significant difference in the ODI in the SS group compared with both the AA and AS groups. There was no statistical significance in the ODI between the AA and AS groups. The ODI may be considered as a useful assessment of oxygen delivery in subjects with sickle cell disease. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/19126993/Oxygen_delivery_index_in_subjects_with_normal_haemoglobin__HbAA__sickle_cell_trait__HbAS__and_homozygous_sickle_cell_disease__HbSS__ L2 - https://content.iospress.com/openurl?genre=article&issn=1386-0291&volume=40&issue=4&spage=303 DB - PRIME DP - Unbound Medicine ER -