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Increases in urinary 9alpha,11beta-prostaglandin f2 indicate mast cell activation in wine-induced asthma.
Int Arch Allergy Immunol 2009; 149(2):127-32IA

Abstract

BACKGROUND

Wine-induced asthmatic symptoms may be caused by sulphite additives. Prostaglandin (PG)D2 and cysteinyl leukotrienes (cysLT) are important mediators of asthmatic responses. To determine whether the sulphite additives in wine alter the production of PGD2 and cysLT, asthmatic patients with compelling histories of wine sensitivity were challenged with high- and low-sulphite wines; the urinary metabolites of PGD2 and cysLT were measured before and after challenge.

METHODS

Eight self-reporting wine-sensitive asthmatic patients completed double-blind challenges with high- and low-sulphite wines on separate days. Urine samples were collected before and after consumption of 150 ml of wine. Urinary concentrations of 9alpha,11beta-PGF2 and leukotriene (LT)E4 were measured by enzyme immunoassay.

RESULTS

Urinary 9alpha,11beta-PGF2 concentrations increased in all subjects following challenge with high-sulphite wine, and the median concentration increased 1.6-fold (p < 0.01). Urinary 9alpha,11beta-PGF2 also increased 1.5-fold after low-sulphite wine challenge, although this did not reach statistical significance (p = 0.08). The median difference in 9alpha,11beta-PGF2 concentration after high-sulphite wine challenge was not significantly different compared with that after low-sulphite wine challenge. Median urinary LTE4 concentrations did not change significantly after either wine challenge.

CONCLUSIONS

Increased urinary 9alpha,11beta-PGF2 concentrations following wine challenge suggest mast cell activation as a possible mechanism for wine-induced asthma, although this did not appear to be related to the sulphite additives in wine. Urinary 9alpha,11beta-PGF2 may warrant further assessment as a potential biomarker of reactivity to wine in asthmatic subjects.

Authors+Show Affiliations

Lung Institute of Western Australia Inc., Centre for Asthma, Allergy and Respiratory Research, Ground Floor, E Block, Sir Charles Gairdner Hospital, Verdun Street, Nedlands, W.A. 6009, Australia. nmisso@liwa.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19127069

Citation

Misso, Neil L A., et al. "Increases in Urinary 9alpha,11beta-prostaglandin F2 Indicate Mast Cell Activation in Wine-induced Asthma." International Archives of Allergy and Immunology, vol. 149, no. 2, 2009, pp. 127-32.
Misso NL, Aggarwal S, Thompson PJ, et al. Increases in urinary 9alpha,11beta-prostaglandin f2 indicate mast cell activation in wine-induced asthma. Int Arch Allergy Immunol. 2009;149(2):127-32.
Misso, N. L., Aggarwal, S., Thompson, P. J., & Vally, H. (2009). Increases in urinary 9alpha,11beta-prostaglandin f2 indicate mast cell activation in wine-induced asthma. International Archives of Allergy and Immunology, 149(2), pp. 127-32. doi:10.1159/000189195.
Misso NL, et al. Increases in Urinary 9alpha,11beta-prostaglandin F2 Indicate Mast Cell Activation in Wine-induced Asthma. Int Arch Allergy Immunol. 2009;149(2):127-32. PubMed PMID: 19127069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increases in urinary 9alpha,11beta-prostaglandin f2 indicate mast cell activation in wine-induced asthma. AU - Misso,Neil L A, AU - Aggarwal,Shashi, AU - Thompson,Philip J, AU - Vally,Hassan, Y1 - 2009/01/06/ PY - 2008/06/16/received PY - 2008/08/11/accepted PY - 2009/1/8/entrez PY - 2009/1/8/pubmed PY - 2009/6/10/medline SP - 127 EP - 32 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 149 IS - 2 N2 - BACKGROUND: Wine-induced asthmatic symptoms may be caused by sulphite additives. Prostaglandin (PG)D2 and cysteinyl leukotrienes (cysLT) are important mediators of asthmatic responses. To determine whether the sulphite additives in wine alter the production of PGD2 and cysLT, asthmatic patients with compelling histories of wine sensitivity were challenged with high- and low-sulphite wines; the urinary metabolites of PGD2 and cysLT were measured before and after challenge. METHODS: Eight self-reporting wine-sensitive asthmatic patients completed double-blind challenges with high- and low-sulphite wines on separate days. Urine samples were collected before and after consumption of 150 ml of wine. Urinary concentrations of 9alpha,11beta-PGF2 and leukotriene (LT)E4 were measured by enzyme immunoassay. RESULTS: Urinary 9alpha,11beta-PGF2 concentrations increased in all subjects following challenge with high-sulphite wine, and the median concentration increased 1.6-fold (p < 0.01). Urinary 9alpha,11beta-PGF2 also increased 1.5-fold after low-sulphite wine challenge, although this did not reach statistical significance (p = 0.08). The median difference in 9alpha,11beta-PGF2 concentration after high-sulphite wine challenge was not significantly different compared with that after low-sulphite wine challenge. Median urinary LTE4 concentrations did not change significantly after either wine challenge. CONCLUSIONS: Increased urinary 9alpha,11beta-PGF2 concentrations following wine challenge suggest mast cell activation as a possible mechanism for wine-induced asthma, although this did not appear to be related to the sulphite additives in wine. Urinary 9alpha,11beta-PGF2 may warrant further assessment as a potential biomarker of reactivity to wine in asthmatic subjects. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/19127069/Increases_in_urinary_9alpha11beta_prostaglandin_f2_indicate_mast_cell_activation_in_wine_induced_asthma_ L2 - https://www.karger.com?DOI=10.1159/000189195 DB - PRIME DP - Unbound Medicine ER -