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Nonmotor manifestations of Parkinson's disease.
Ann Neurol. 2008 Dec; 64 Suppl 2:S65-80.AN

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Traditionally, attention has focused on the motor symptomatology of PD, but it is now appreciated that the nonmotor symptoms affecting neuropsychiatric, sleep, autonomic, and sensory domains occur in up to 88% of PD patients and can be an important source of disability. Nonmotor manifestations of PD play a significant role in the impairment of disease-related quality of life. The cause of nonmotor manifestations of PD is multifactorial, but to a large extent, these manifestations are related to the nature of the neurodegenerative process and the widespread nondopaminergic neuropathological changes associated with the disease. Recognition of nonmotor disability is essential not only for ascertaining the functional status of patients but also for better appreciating the nature of the neurodegenerative process in PD. In addition, a number of nonmotor manifestations can precede the onset of motor symptoms in PD and can be used as screening tools allowing for early disease identification and for trials of possible disease-modifying interventions. This article reviews depression, sleep, and autonomic dysfunction in PD.

Authors+Show Affiliations

Department of Neurology, Northwestern University, Chicago, IL, USA. tsimuni@nmff.orgNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19127582

Citation

Simuni, Tanya, and Kapil Sethi. "Nonmotor Manifestations of Parkinson's Disease." Annals of Neurology, vol. 64 Suppl 2, 2008, pp. S65-80.
Simuni T, Sethi K. Nonmotor manifestations of Parkinson's disease. Ann Neurol. 2008;64 Suppl 2:S65-80.
Simuni, T., & Sethi, K. (2008). Nonmotor manifestations of Parkinson's disease. Annals of Neurology, 64 Suppl 2, S65-80. https://doi.org/10.1002/ana.21472
Simuni T, Sethi K. Nonmotor Manifestations of Parkinson's Disease. Ann Neurol. 2008;64 Suppl 2:S65-80. PubMed PMID: 19127582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonmotor manifestations of Parkinson's disease. AU - Simuni,Tanya, AU - Sethi,Kapil, PY - 2009/1/8/entrez PY - 2009/1/8/pubmed PY - 2009/2/10/medline SP - S65 EP - 80 JF - Annals of neurology JO - Ann Neurol VL - 64 Suppl 2 N2 - Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Traditionally, attention has focused on the motor symptomatology of PD, but it is now appreciated that the nonmotor symptoms affecting neuropsychiatric, sleep, autonomic, and sensory domains occur in up to 88% of PD patients and can be an important source of disability. Nonmotor manifestations of PD play a significant role in the impairment of disease-related quality of life. The cause of nonmotor manifestations of PD is multifactorial, but to a large extent, these manifestations are related to the nature of the neurodegenerative process and the widespread nondopaminergic neuropathological changes associated with the disease. Recognition of nonmotor disability is essential not only for ascertaining the functional status of patients but also for better appreciating the nature of the neurodegenerative process in PD. In addition, a number of nonmotor manifestations can precede the onset of motor symptoms in PD and can be used as screening tools allowing for early disease identification and for trials of possible disease-modifying interventions. This article reviews depression, sleep, and autonomic dysfunction in PD. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/19127582/Nonmotor_manifestations_of_Parkinson's_disease_ L2 - https://doi.org/10.1002/ana.21472 DB - PRIME DP - Unbound Medicine ER -