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Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder.
J Psychiatr Res. 2009 Jun; 43(9):855-63.JP

Abstract

Patients with major depressive disorder (MDD) usually suffer from altered cognitive functions of episodic memory, working memory, mental processing speed and motor response. Diverse studies suggest that different antidepressant agents may improve cognitive functions in patients with MDD. The aim of this work is to study the effects of serotonergic reuptake inhibitors (SSRIs) and serotonergic-noradrenergic reuptake inhibitors (SNRIs) treatments to improve the performance on memory tasks and mental processing speed in MDD. Seventy-three subjects meeting criteria for major depressive disorder were assessed with the Hamilton depression rating scale and a neuropsychological battery. The subjects were medicated with escitalopram (n=36) or duloxetine (n=37) for 24 weeks. At the end of the trial, the subjects were assessed again with the same neuropsychological battery used prior to the treatment. Both treatments improved importantly the episodic memory and to a lesser extent, working memory, mental processing speed and motor performance. Our results suggest that cognition is partially independent from improvement in clinical symptoms. Both groups achieved remission rates in the HAM-D-17 after 24 weeks of treatment, but SNRI was superior to SSRI at improving episodic and working memory. Our work indicates that the superiority of SNRI over the SSRI at episodic memory improvement is clinically relevant.

Authors+Show Affiliations

Clínica de Enfermedades Crónicas y Procedimientos Especiales CECYPE, Morelia, Mich., Mexico. iherrera@zeus.umich.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19128810

Citation

Herrera-Guzmán, Ixchel, et al. "Effects of Selective Serotonin Reuptake and Dual Serotonergic-noradrenergic Reuptake Treatments On Memory and Mental Processing Speed in Patients With Major Depressive Disorder." Journal of Psychiatric Research, vol. 43, no. 9, 2009, pp. 855-63.
Herrera-Guzmán I, Gudayol-Ferré E, Herrera-Guzmán D, et al. Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder. J Psychiatr Res. 2009;43(9):855-63.
Herrera-Guzmán, I., Gudayol-Ferré, E., Herrera-Guzmán, D., Guàrdia-Olmos, J., Hinojosa-Calvo, E., & Herrera-Abarca, J. E. (2009). Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder. Journal of Psychiatric Research, 43(9), 855-63. https://doi.org/10.1016/j.jpsychires.2008.10.015
Herrera-Guzmán I, et al. Effects of Selective Serotonin Reuptake and Dual Serotonergic-noradrenergic Reuptake Treatments On Memory and Mental Processing Speed in Patients With Major Depressive Disorder. J Psychiatr Res. 2009;43(9):855-63. PubMed PMID: 19128810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder. AU - Herrera-Guzmán,Ixchel, AU - Gudayol-Ferré,Esteve, AU - Herrera-Guzmán,Daniel, AU - Guàrdia-Olmos,Joan, AU - Hinojosa-Calvo,Erika, AU - Herrera-Abarca,Jorge E, Y1 - 2009/01/06/ PY - 2008/09/11/received PY - 2008/10/23/revised PY - 2008/10/28/accepted PY - 2009/1/9/entrez PY - 2009/1/9/pubmed PY - 2009/7/16/medline SP - 855 EP - 63 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 43 IS - 9 N2 - Patients with major depressive disorder (MDD) usually suffer from altered cognitive functions of episodic memory, working memory, mental processing speed and motor response. Diverse studies suggest that different antidepressant agents may improve cognitive functions in patients with MDD. The aim of this work is to study the effects of serotonergic reuptake inhibitors (SSRIs) and serotonergic-noradrenergic reuptake inhibitors (SNRIs) treatments to improve the performance on memory tasks and mental processing speed in MDD. Seventy-three subjects meeting criteria for major depressive disorder were assessed with the Hamilton depression rating scale and a neuropsychological battery. The subjects were medicated with escitalopram (n=36) or duloxetine (n=37) for 24 weeks. At the end of the trial, the subjects were assessed again with the same neuropsychological battery used prior to the treatment. Both treatments improved importantly the episodic memory and to a lesser extent, working memory, mental processing speed and motor performance. Our results suggest that cognition is partially independent from improvement in clinical symptoms. Both groups achieved remission rates in the HAM-D-17 after 24 weeks of treatment, but SNRI was superior to SSRI at improving episodic and working memory. Our work indicates that the superiority of SNRI over the SSRI at episodic memory improvement is clinically relevant. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/19128810/Effects_of_selective_serotonin_reuptake_and_dual_serotonergic_noradrenergic_reuptake_treatments_on_memory_and_mental_processing_speed_in_patients_with_major_depressive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(08)00243-4 DB - PRIME DP - Unbound Medicine ER -