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Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs.

Abstract

Forty patients with rheumatoid arthritis and upper gastrointestinal lesions due to non-steroidal anti-inflammatory drugs entered a prospective 6-month double-blind placebo controlled study of dietary supplementation with gamma-linolenic acid 540 mg/day. Nineteen patients received active therapy (as evening primrose oil 6 g/day) and 21 received placebo (olive oil 6 g/day). No patient stopped non-steroidal anti-inflammatory therapy but three patients in each group reduced their dose. Other results showed a significant reduction in morning stiffness with gamma-linolenic acid at 3 months and reduction in pain and articular index at 6 months with olive oil. Whilst gamma-linolenic acid may produce mild improvement in rheumatoid arthritis, olive oil may itself have hitherto unrecognized benefits.

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Authors+Show Affiliations

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University Department of Medicine, Royal Infirmary, Glasgow.

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Source

British journal of rheumatology 30:5 1991 Oct pg 370-2

MeSH

Adolescent
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal
Arthritis, Rheumatoid
Double-Blind Method
Fatty Acids, Essential
Female
Gastritis
Humans
Linoleic Acids
Male
Middle Aged
Olive Oil
Peptic Ulcer
Plant Oils
Prospective Studies
gamma-Linolenic Acid

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1913008

Citation

Brzeski, M, et al. "Evening Primrose Oil in Patients With Rheumatoid Arthritis and Side-effects of Non-steroidal Anti-inflammatory Drugs." British Journal of Rheumatology, vol. 30, no. 5, 1991, pp. 370-2.
Brzeski M, Madhok R, Capell HA. Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. Br J Rheumatol. 1991;30(5):370-2.
Brzeski, M., Madhok, R., & Capell, H. A. (1991). Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. British Journal of Rheumatology, 30(5), pp. 370-2.
Brzeski M, Madhok R, Capell HA. Evening Primrose Oil in Patients With Rheumatoid Arthritis and Side-effects of Non-steroidal Anti-inflammatory Drugs. Br J Rheumatol. 1991;30(5):370-2. PubMed PMID: 1913008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. AU - Brzeski,M, AU - Madhok,R, AU - Capell,H A, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 370 EP - 2 JF - British journal of rheumatology JO - Br. J. Rheumatol. VL - 30 IS - 5 N2 - Forty patients with rheumatoid arthritis and upper gastrointestinal lesions due to non-steroidal anti-inflammatory drugs entered a prospective 6-month double-blind placebo controlled study of dietary supplementation with gamma-linolenic acid 540 mg/day. Nineteen patients received active therapy (as evening primrose oil 6 g/day) and 21 received placebo (olive oil 6 g/day). No patient stopped non-steroidal anti-inflammatory therapy but three patients in each group reduced their dose. Other results showed a significant reduction in morning stiffness with gamma-linolenic acid at 3 months and reduction in pain and articular index at 6 months with olive oil. Whilst gamma-linolenic acid may produce mild improvement in rheumatoid arthritis, olive oil may itself have hitherto unrecognized benefits. SN - 0263-7103 UR - https://www.unboundmedicine.com/medline/citation/1913008/Evening_primrose_oil_in_patients_with_rheumatoid_arthritis_and_side_effects_of_non_steroidal_anti_inflammatory_drugs_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -