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Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors.
Fertil Steril. 2010 Mar 01; 93(4):1200-7.FS

Abstract

OBJECTIVE

To determine serum interleukin (IL)-18 levels and to find out whether IL-18 is associated with carotid intima-media wall thickness (IMT) and various cardiovascular risk factors in women with polycystic ovary syndrome (PCOS).

DESIGN

A prospective, controlled study.

SETTING

University hospital.

PATIENT(S)

Sixty women with PCOS and 60 healthy women were included this study.

INTERVENTION(S)

Serum levels IL-18, homocysteine (Hcy), C-reactive protein (CRP), IL-6, malonyldialdehyde (MDA), lipid and hormone profiles were measured. Carotid IMT was evaluated for both common carotid arteries.

MAIN OUTCOME MEASURE(S)

Serum IL-18, carotid IMT, Hcy, CRP, IL-6, MDA, and homeostasis model assessment of insulin resistance.

RESULT(S)

The evaluation, which was made without the obesity influence taken into consideration, revealed that patients with PCOS have increased serum IL-18 levels than that of the control group (214 +/- 102 vs. 170 +/- 78 pg/mL). The interaction between PCOS and obesity was seen to have statistical significance (F = 67.8). Body mass index (BMI), waist to-hip ratio, Hcy, and homeostasis model assessment of insulin resistance are independent determinants of plasma IL-18 in patients with PCOS. Elevated serum IL-18 levels were positively and significantly correlated with a greater carotid IMT. For Hcy and carotid IMT, the interaction between PCOS and obesity was found in a two-way ANOVA variation analysis (F = 48.5 and F = 81.5, respectively).

CONCLUSION(S)

Elevated serum IL-18 levels were associated with cardiovascular risk factors and carotid IMT in patients with PCOS.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Kaya C
Department of Obstetrics and Gynecology, Ufuk University, Balgat, 312Ankara, Ankara, Turkey. kayacemil000@yahoo.com
Pabuccu R
No affiliation info available
Berker B
No affiliation info available
Satiroglu H
No affiliation info available

MeSH

AtherosclerosisBody Mass IndexC-Reactive ProteinCardiovascular DiseasesCarotid ArteriesFemaleHumansInsulin ResistanceInterleukin-18Polycystic Ovary SyndromePredictive Value of TestsProspective StudiesRisk FactorsTunica IntimaTunica Media

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

19131059

Citation

Kaya, Cemil, et al. "Plasma Interleukin-18 Levels Are Increased in the Polycystic Ovary Syndrome: Relationship of Carotid Intima-media Wall Thickness and Cardiovascular Risk Factors." Fertility and Sterility, vol. 93, no. 4, 2010, pp. 1200-7.
Kaya C, Pabuccu R, Berker B, et al. Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. Fertil Steril. 2010;93(4):1200-7.
Kaya, C., Pabuccu, R., Berker, B., & Satiroglu, H. (2010). Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. Fertility and Sterility, 93(4), 1200-7. https://doi.org/10.1016/j.fertnstert.2008.10.070
Kaya C, et al. Plasma Interleukin-18 Levels Are Increased in the Polycystic Ovary Syndrome: Relationship of Carotid Intima-media Wall Thickness and Cardiovascular Risk Factors. Fertil Steril. 2010 Mar 1;93(4):1200-7. PubMed PMID: 19131059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. AU - Kaya,Cemil, AU - Pabuccu,Recai, AU - Berker,Bülent, AU - Satiroglu,Hakan, Y1 - 2009/01/07/ PY - 2008/05/31/received PY - 2008/10/29/revised PY - 2008/10/30/accepted PY - 2009/1/10/entrez PY - 2009/1/10/pubmed PY - 2010/4/2/medline SP - 1200 EP - 7 JF - Fertility and sterility JO - Fertil Steril VL - 93 IS - 4 N2 - OBJECTIVE: To determine serum interleukin (IL)-18 levels and to find out whether IL-18 is associated with carotid intima-media wall thickness (IMT) and various cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). DESIGN: A prospective, controlled study. SETTING: University hospital. PATIENT(S): Sixty women with PCOS and 60 healthy women were included this study. INTERVENTION(S): Serum levels IL-18, homocysteine (Hcy), C-reactive protein (CRP), IL-6, malonyldialdehyde (MDA), lipid and hormone profiles were measured. Carotid IMT was evaluated for both common carotid arteries. MAIN OUTCOME MEASURE(S): Serum IL-18, carotid IMT, Hcy, CRP, IL-6, MDA, and homeostasis model assessment of insulin resistance. RESULT(S): The evaluation, which was made without the obesity influence taken into consideration, revealed that patients with PCOS have increased serum IL-18 levels than that of the control group (214 +/- 102 vs. 170 +/- 78 pg/mL). The interaction between PCOS and obesity was seen to have statistical significance (F = 67.8). Body mass index (BMI), waist to-hip ratio, Hcy, and homeostasis model assessment of insulin resistance are independent determinants of plasma IL-18 in patients with PCOS. Elevated serum IL-18 levels were positively and significantly correlated with a greater carotid IMT. For Hcy and carotid IMT, the interaction between PCOS and obesity was found in a two-way ANOVA variation analysis (F = 48.5 and F = 81.5, respectively). CONCLUSION(S): Elevated serum IL-18 levels were associated with cardiovascular risk factors and carotid IMT in patients with PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19131059/Plasma_interleukin_18_levels_are_increased_in_the_polycystic_ovary_syndrome:_relationship_of_carotid_intima_media_wall_thickness_and_cardiovascular_risk_factors_ DB - PRIME DP - Unbound Medicine ER -