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Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans.
Int J Cardiol 2009; 134(3):313-21IJ

Abstract

BACKGROUND

The purpose of this study was to investigate whether the presence of the NCEP-ATP III defined metabolic syndrome (MS) is associated with the future development of cardiovascular disease (CVD) and diabetes in Koreans.

METHODS

The study subjects were recruited from among those who visited the Health Promotion Center at the Samsung Medical Center. 2435 subjects (1761 men and 674 women), 20 to 78 years of age, were enrolled and evaluated for the development of new onset CVD (coronary heart disease [CHD] and stroke) during a mean 8.7 years of follow-up.

RESULTS

The prevalence of the MS at baseline was 21.7% (382/1761) and 11.4% (77/674) in men and women respectively, and the MS was found to be associated with the risk for CVD in both men and women (OR, 1.98; 95% CI, 1.30-3.03 in men, 4.04; 95% CI, 1.78-9.14 in women). More specifically, the MS was associated with the risk for future CHD (OR, 3.68; 95% CI, 1.93-7.01) in men and stroke (OR, 3.96; 95% CI, 1.58-9.94) in women. However, no statistical differences were found between the HOMA-IR tertiles with regard to the risk for CVD. After controlling for fasting plasma glucose (FPG) levels, the predictive power of the MS for an increased risk for diabetes was dramatically decreased (OR, from 3.69 to 1.77) in men, and it no longer was a predictor in women.

CONCLUSIONS

The NCEP-defined MS was found to be associated with the risk for future CVD, i.e., CHD in men and stroke in women.

Authors+Show Affiliations

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19131127

Citation

Hwang, You-Cheol, et al. "Metabolic Syndrome as a Predictor of Cardiovascular Diseases and Type 2 Diabetes in Koreans." International Journal of Cardiology, vol. 134, no. 3, 2009, pp. 313-21.
Hwang YC, Jee JH, Oh EY, et al. Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans. Int J Cardiol. 2009;134(3):313-21.
Hwang, Y. C., Jee, J. H., Oh, E. Y., Choi, Y. H., Lee, M. S., Kim, K. W., & Lee, M. K. (2009). Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans. International Journal of Cardiology, 134(3), pp. 313-21. doi:10.1016/j.ijcard.2008.12.025.
Hwang YC, et al. Metabolic Syndrome as a Predictor of Cardiovascular Diseases and Type 2 Diabetes in Koreans. Int J Cardiol. 2009 May 29;134(3):313-21. PubMed PMID: 19131127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans. AU - Hwang,You-Cheol, AU - Jee,Jae-Hwan, AU - Oh,Eun Young, AU - Choi,Yoon-Ho, AU - Lee,Myung-Shik, AU - Kim,Kwang-Won, AU - Lee,Moon-Kyu, Y1 - 2009/01/08/ PY - 2008/05/31/received PY - 2008/10/29/revised PY - 2008/12/03/accepted PY - 2009/1/10/entrez PY - 2009/1/10/pubmed PY - 2010/2/17/medline SP - 313 EP - 21 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 134 IS - 3 N2 - BACKGROUND: The purpose of this study was to investigate whether the presence of the NCEP-ATP III defined metabolic syndrome (MS) is associated with the future development of cardiovascular disease (CVD) and diabetes in Koreans. METHODS: The study subjects were recruited from among those who visited the Health Promotion Center at the Samsung Medical Center. 2435 subjects (1761 men and 674 women), 20 to 78 years of age, were enrolled and evaluated for the development of new onset CVD (coronary heart disease [CHD] and stroke) during a mean 8.7 years of follow-up. RESULTS: The prevalence of the MS at baseline was 21.7% (382/1761) and 11.4% (77/674) in men and women respectively, and the MS was found to be associated with the risk for CVD in both men and women (OR, 1.98; 95% CI, 1.30-3.03 in men, 4.04; 95% CI, 1.78-9.14 in women). More specifically, the MS was associated with the risk for future CHD (OR, 3.68; 95% CI, 1.93-7.01) in men and stroke (OR, 3.96; 95% CI, 1.58-9.94) in women. However, no statistical differences were found between the HOMA-IR tertiles with regard to the risk for CVD. After controlling for fasting plasma glucose (FPG) levels, the predictive power of the MS for an increased risk for diabetes was dramatically decreased (OR, from 3.69 to 1.77) in men, and it no longer was a predictor in women. CONCLUSIONS: The NCEP-defined MS was found to be associated with the risk for future CVD, i.e., CHD in men and stroke in women. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/19131127/Metabolic_syndrome_as_a_predictor_of_cardiovascular_diseases_and_type_2_diabetes_in_Koreans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(08)01411-3 DB - PRIME DP - Unbound Medicine ER -