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The relation of testosterone levels with fatigue and apathy in Parkinson's disease.
Clin Neurol Neurosurg. 2009 Jun; 111(5):412-4.CN

Abstract

OBJECTIVE

Fatigue and apathy are frequent in patients with Parkinson's disease (PD). Testosterone deficiency in male patients may contribute in development of fatigue and apathy as well. We investigated whether a possible relation exists between serum testosterone levels, fatigue and apathy in male PD patients.

MATERIALS AND METHODS

We included 29 non-demented and non-depressed PD patients and 30 age- and sex-matched healthy subjects. Fatigue Severity Scale (FSS) and Apathy Evaluation Scale (AES-C) were used for the evaluations. In PD patients and healthy subjects, a relationship between FSS, AES-C scores and plasma testosterone levels were assessed. In addition, a correlation between FSS, AES-C and Unified Parkinson's Disease Rating Scale was investigated in PD group.

RESULTS

The mean scores of FSS and AES-C were significantly higher in PD patients than those of the control group. The Unified Parkinson's Disease Rating Scale (UPDRS) scores were significantly correlated with FSS and AES-C scores. Mean free testosterone level was significantly lower in PD patients than controls (p=0.008). f-Testosterone levels of PD patients were not correlated with FSS or AES-C scores.

CONCLUSION

Apathy and fatigue are frequent in PD and show significant correlation with the severity of the disease. f-Testosterone levels are not related with apathy or fatigue in male PD patients and the role of testosterone in the pathophysiology of these non-motor symptoms is still controversial.

Authors+Show Affiliations

Department of Neurology, Education and Research Hospital of Sisli Etfal, Istanbul, Turkey. kenangil@superonline.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19131155

Citation

Kenangil, Gülay, et al. "The Relation of Testosterone Levels With Fatigue and Apathy in Parkinson's Disease." Clinical Neurology and Neurosurgery, vol. 111, no. 5, 2009, pp. 412-4.
Kenangil G, Orken DN, Ur E, et al. The relation of testosterone levels with fatigue and apathy in Parkinson's disease. Clin Neurol Neurosurg. 2009;111(5):412-4.
Kenangil, G., Orken, D. N., Ur, E., Forta, H., & Celik, M. (2009). The relation of testosterone levels with fatigue and apathy in Parkinson's disease. Clinical Neurology and Neurosurgery, 111(5), 412-4. https://doi.org/10.1016/j.clineuro.2008.11.019
Kenangil G, et al. The Relation of Testosterone Levels With Fatigue and Apathy in Parkinson's Disease. Clin Neurol Neurosurg. 2009;111(5):412-4. PubMed PMID: 19131155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation of testosterone levels with fatigue and apathy in Parkinson's disease. AU - Kenangil,Gülay, AU - Orken,Dilek Necioglu, AU - Ur,Emel, AU - Forta,Hulki, AU - Celik,Munevver, Y1 - 2009/01/08/ PY - 2008/02/14/received PY - 2008/11/18/revised PY - 2008/11/30/accepted PY - 2009/1/10/entrez PY - 2009/1/10/pubmed PY - 2009/7/16/medline SP - 412 EP - 4 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 111 IS - 5 N2 - OBJECTIVE: Fatigue and apathy are frequent in patients with Parkinson's disease (PD). Testosterone deficiency in male patients may contribute in development of fatigue and apathy as well. We investigated whether a possible relation exists between serum testosterone levels, fatigue and apathy in male PD patients. MATERIALS AND METHODS: We included 29 non-demented and non-depressed PD patients and 30 age- and sex-matched healthy subjects. Fatigue Severity Scale (FSS) and Apathy Evaluation Scale (AES-C) were used for the evaluations. In PD patients and healthy subjects, a relationship between FSS, AES-C scores and plasma testosterone levels were assessed. In addition, a correlation between FSS, AES-C and Unified Parkinson's Disease Rating Scale was investigated in PD group. RESULTS: The mean scores of FSS and AES-C were significantly higher in PD patients than those of the control group. The Unified Parkinson's Disease Rating Scale (UPDRS) scores were significantly correlated with FSS and AES-C scores. Mean free testosterone level was significantly lower in PD patients than controls (p=0.008). f-Testosterone levels of PD patients were not correlated with FSS or AES-C scores. CONCLUSION: Apathy and fatigue are frequent in PD and show significant correlation with the severity of the disease. f-Testosterone levels are not related with apathy or fatigue in male PD patients and the role of testosterone in the pathophysiology of these non-motor symptoms is still controversial. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/19131155/The_relation_of_testosterone_levels_with_fatigue_and_apathy_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(08)00406-X DB - PRIME DP - Unbound Medicine ER -