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Experimental study of the relationship between perfluoro-octyl bromide emulsion and norepinephrine release in reperfusion arrhythmia: isolated guinea pig heart model.
Ann Thorac Cardiovasc Surg. 2008 Dec; 14(6):363-8.AT

Abstract

BACKGROUND

Perfluoro-octyl bromide (PFOB), one of the perfluorochemical oxygen transporters, improved postischemic cardiac dysfunctions. Also norepinephrine (NE) is one of the important inducible factors on reperfusion arrhythmias (ventricular fibrillation [VF]). We used these methods to evaluate the relationship between PFOB emulsion and NE release on reperfusion arrhythmias.

MATERIALS AND METHODS

The perfusion of isolated guinea pig hearts was employed: each of four groups of 6-7 hearts were used with Krebs-Henseleit solution (KHS) as control, and KHS with 5%, 15%, or 30% PFOB emulsion. The hearts were perfused in a constant pressure Langendorff model, stabilized for 30 min, followed by 30 min preischemia, then 30 min ischemia and 45 min reperfusion at normothermia.

RESULTS

PFOB emulsion dose-dependently limited VF and inhibited NE release in reperfusion. Only 30% PFOB emulsion showed the significant improvement of VF (p=0.05). In hemodynamic parameters, only 5% PFOB emulsion showed a significant decrease in reperfusion, but there was no difference in coronary flow rate (CFR). No differences among the four groups were demonstrated in cardiac oxygen metabolic parameters.

CONCLUSIONS

It was most likely that a high concentration of PFOB emulsion attenuated reperfusion arrhythmia by decreasing NE release.

Authors+Show Affiliations

Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19131922

Citation

Isaka, Mitsuhiro, et al. "Experimental Study of the Relationship Between Perfluoro-octyl Bromide Emulsion and Norepinephrine Release in Reperfusion Arrhythmia: Isolated Guinea Pig Heart Model." Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, vol. 14, no. 6, 2008, pp. 363-8.
Isaka M, Sakuma I, Shiiya N, et al. Experimental study of the relationship between perfluoro-octyl bromide emulsion and norepinephrine release in reperfusion arrhythmia: isolated guinea pig heart model. Ann Thorac Cardiovasc Surg. 2008;14(6):363-8.
Isaka, M., Sakuma, I., Shiiya, N., Fukushima, S., Nakai, K., Kitabatake, A., & Yasuda, K. (2008). Experimental study of the relationship between perfluoro-octyl bromide emulsion and norepinephrine release in reperfusion arrhythmia: isolated guinea pig heart model. Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 14(6), 363-8.
Isaka M, et al. Experimental Study of the Relationship Between Perfluoro-octyl Bromide Emulsion and Norepinephrine Release in Reperfusion Arrhythmia: Isolated Guinea Pig Heart Model. Ann Thorac Cardiovasc Surg. 2008;14(6):363-8. PubMed PMID: 19131922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental study of the relationship between perfluoro-octyl bromide emulsion and norepinephrine release in reperfusion arrhythmia: isolated guinea pig heart model. AU - Isaka,Mitsuhiro, AU - Sakuma,Ichiro, AU - Shiiya,Norihiko, AU - Fukushima,Shoji, AU - Nakai,Kunihiko, AU - Kitabatake,Akira, AU - Yasuda,Keishu, PY - 2006/12/04/received PY - 2007/11/20/accepted PY - 2009/1/10/entrez PY - 2009/1/10/pubmed PY - 2009/3/20/medline SP - 363 EP - 8 JF - Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia JO - Ann Thorac Cardiovasc Surg VL - 14 IS - 6 N2 - BACKGROUND: Perfluoro-octyl bromide (PFOB), one of the perfluorochemical oxygen transporters, improved postischemic cardiac dysfunctions. Also norepinephrine (NE) is one of the important inducible factors on reperfusion arrhythmias (ventricular fibrillation [VF]). We used these methods to evaluate the relationship between PFOB emulsion and NE release on reperfusion arrhythmias. MATERIALS AND METHODS: The perfusion of isolated guinea pig hearts was employed: each of four groups of 6-7 hearts were used with Krebs-Henseleit solution (KHS) as control, and KHS with 5%, 15%, or 30% PFOB emulsion. The hearts were perfused in a constant pressure Langendorff model, stabilized for 30 min, followed by 30 min preischemia, then 30 min ischemia and 45 min reperfusion at normothermia. RESULTS: PFOB emulsion dose-dependently limited VF and inhibited NE release in reperfusion. Only 30% PFOB emulsion showed the significant improvement of VF (p=0.05). In hemodynamic parameters, only 5% PFOB emulsion showed a significant decrease in reperfusion, but there was no difference in coronary flow rate (CFR). No differences among the four groups were demonstrated in cardiac oxygen metabolic parameters. CONCLUSIONS: It was most likely that a high concentration of PFOB emulsion attenuated reperfusion arrhythmia by decreasing NE release. SN - 2186-1005 UR - https://www.unboundmedicine.com/medline/citation/19131922/Experimental_study_of_the_relationship_between_perfluoro_octyl_bromide_emulsion_and_norepinephrine_release_in_reperfusion_arrhythmia:_isolated_guinea_pig_heart_model_ DB - PRIME DP - Unbound Medicine ER -