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[Effects of rhBNP on left ventricular remodeling in rats with acute myocardial infarction].
Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Dec; 36(12):1097-100.ZX

Abstract

OBJECTIVE

To assess the effects of rhBNP on left ventricular (LV) remodeling in rats with acute myocardial infarction (AMI).

METHODS

AMI was induced by ligating coronary artery in male Sprague Dawley rats. Two days after surgery, AMI rats received intravenous infusion of rhBNP (15 microg/kg or 5 microg/kg once daily, n = 15 each) or saline (placebo control, n = 15) through Jugular Vein. Sham-operated rats (n = 15) served as normal control. Four weeks later, hemodynamic measurements were performed, left ventricular weight (LVW), ratio of left ventricular weight to body weight (LVW/BW), left ventricular diameter (LVD) and infarct size were determined. Plasma angiotensin II and myocardial angiotensin II levels were also measured.

RESULTS

Compared with sham-operated rats, LVW, LVW/BW, LVD and myocardial angiotensin II level were significantly increased, while the LV systolic pressure (LVSP), +/- dp/dt were significantly reduced in saline treated AMI rats (all P < 0.05). LVW/BW, MI size, LVD and myocardial angiotensin II in rhBNP treated AMI rats were significantly lower [LVW: (492.6 +/- 34.0) mg, (498.8 +/- 47.8) mg, (570.0 +/- 24.2) mg, P < 0.01; LVW/BW: 2.0 +/- 0.2, 2.0 +/- 0.2, 2.3 +/- 0.1, P < 0.01; LVD: (25.3 +/- 2.9)%, (31.4 +/- 3.0)%, (46.4 +/- 3.0)%, P < 0.01; myocardial angiotensin II: (881.3 +/- 62.7) pg/L, (1186.0 +/- 94.5) pg/L, (2436.7 +/- 280.3) pg/L, P < 0.05], while LVSP and +/- dp/dt in rhBNP treatment groups were significantly increased than saline treated AMI rats (P < 0.05 or P < 0.01).

CONCLUSION

RhBNP is effective in attenuating left ventricular remodeling after AMI in rats.

Authors+Show Affiliations

Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19134278

Citation

FAN, Yuan-qiao, et al. "[Effects of rhBNP On Left Ventricular Remodeling in Rats With Acute Myocardial Infarction]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 36, no. 12, 2008, pp. 1097-100.
FAN YQ, HE JG, CHEN YL, et al. [Effects of rhBNP on left ventricular remodeling in rats with acute myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36(12):1097-100.
FAN, Y. Q., HE, J. G., CHEN, Y. L., Chen, G., MA, H., ZHOU, X. L., HU, X. W., PENG, H. W., & ZHAO, B. (2008). [Effects of rhBNP on left ventricular remodeling in rats with acute myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi, 36(12), 1097-100.
FAN YQ, et al. [Effects of rhBNP On Left Ventricular Remodeling in Rats With Acute Myocardial Infarction]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36(12):1097-100. PubMed PMID: 19134278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of rhBNP on left ventricular remodeling in rats with acute myocardial infarction]. AU - FAN,Yuan-qiao, AU - HE,Jian-gui, AU - CHEN,Yi-li, AU - Chen,Gang, AU - MA,Hong, AU - ZHOU,Xun-lun, AU - HU,Xin-wei, AU - PENG,Hong-wei, AU - ZHAO,Bin, PY - 2009/1/13/entrez PY - 2009/1/13/pubmed PY - 2009/8/14/medline SP - 1097 EP - 100 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 36 IS - 12 N2 - OBJECTIVE: To assess the effects of rhBNP on left ventricular (LV) remodeling in rats with acute myocardial infarction (AMI). METHODS: AMI was induced by ligating coronary artery in male Sprague Dawley rats. Two days after surgery, AMI rats received intravenous infusion of rhBNP (15 microg/kg or 5 microg/kg once daily, n = 15 each) or saline (placebo control, n = 15) through Jugular Vein. Sham-operated rats (n = 15) served as normal control. Four weeks later, hemodynamic measurements were performed, left ventricular weight (LVW), ratio of left ventricular weight to body weight (LVW/BW), left ventricular diameter (LVD) and infarct size were determined. Plasma angiotensin II and myocardial angiotensin II levels were also measured. RESULTS: Compared with sham-operated rats, LVW, LVW/BW, LVD and myocardial angiotensin II level were significantly increased, while the LV systolic pressure (LVSP), +/- dp/dt were significantly reduced in saline treated AMI rats (all P < 0.05). LVW/BW, MI size, LVD and myocardial angiotensin II in rhBNP treated AMI rats were significantly lower [LVW: (492.6 +/- 34.0) mg, (498.8 +/- 47.8) mg, (570.0 +/- 24.2) mg, P < 0.01; LVW/BW: 2.0 +/- 0.2, 2.0 +/- 0.2, 2.3 +/- 0.1, P < 0.01; LVD: (25.3 +/- 2.9)%, (31.4 +/- 3.0)%, (46.4 +/- 3.0)%, P < 0.01; myocardial angiotensin II: (881.3 +/- 62.7) pg/L, (1186.0 +/- 94.5) pg/L, (2436.7 +/- 280.3) pg/L, P < 0.05], while LVSP and +/- dp/dt in rhBNP treatment groups were significantly increased than saline treated AMI rats (P < 0.05 or P < 0.01). CONCLUSION: RhBNP is effective in attenuating left ventricular remodeling after AMI in rats. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/19134278/[Effects_of_rhBNP_on_left_ventricular_remodeling_in_rats_with_acute_myocardial_infarction]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3758&amp;year=2008&amp;vol=36&amp;issue=12&amp;fpage=1097 DB - PRIME DP - Unbound Medicine ER -