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Tissue and matrix influences on airway smooth muscle function.
Pulm Pharmacol Ther. 2009 Oct; 22(5):379-87.PP

Abstract

Asthma is characterized by structural changes in the airways - airway remodelling. These changes include an increase in the bulk of the airway smooth muscle (ASM) and alterations in the profile of extracellular matrix (ECM) proteins in the airway wall. The mechanisms leading to airway remodelling are not well understood. ASM cells have the potential to play a key role in these processes through the production and release of ECM proteins. The ASM cells and ECM proteins are each able to influence the behaviour and characteristics of the other. The modified ECM profile in the asthmatic airway may contribute to the altered behaviour of the ASM cells, such responses to ECM proteins are modulated through the cell surface expression of integrin receptors. ASM cells from asthmatic individuals express different levels of some integrin subunits compared to nonasthmatic ASM cells, which have the potential to further influence their responses to the ECM proteins in the airways. ECM homeostasis requires the presence and activation of matrix metalloproteinases and their tissue inhibitors, which in turn modulate the interaction of the ASM cells and the ECM proteins. Furthermore, the complex interactions of the ASM cells and the ECM in the asthmatic airways and the role played by external stimuli, such as viral infections, to modulate airway remodelling are currently unknown. This review summarises our current understanding of the influence of the ECM on ASM function.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Burgess JK
Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia. janette@pharmacol.usyd.edu.au
Ceresa C
No affiliation info available
Johnson SR
No affiliation info available
Kanabar V
No affiliation info available
Moir LM
No affiliation info available
Nguyen TT
No affiliation info available
Oliver BG
No affiliation info available
Schuliga M
No affiliation info available
Ward J
No affiliation info available

MeSH

AsthmaBronchiBronchial HyperreactivityCell DifferentiationExtracellular MatrixExtracellular Matrix ProteinsHumansIntegrinsMatrix MetalloproteinasesModels, BiologicalMuscle CellsMuscle, SmoothPneumonia, ViralPulmonary FibrosisRespiratory System

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19135163

Citation

Burgess, Janette K., et al. "Tissue and Matrix Influences On Airway Smooth Muscle Function." Pulmonary Pharmacology & Therapeutics, vol. 22, no. 5, 2009, pp. 379-87.
Burgess JK, Ceresa C, Johnson SR, et al. Tissue and matrix influences on airway smooth muscle function. Pulm Pharmacol Ther. 2009;22(5):379-87.
Burgess, J. K., Ceresa, C., Johnson, S. R., Kanabar, V., Moir, L. M., Nguyen, T. T., Oliver, B. G., Schuliga, M., & Ward, J. (2009). Tissue and matrix influences on airway smooth muscle function. Pulmonary Pharmacology & Therapeutics, 22(5), 379-87. https://doi.org/10.1016/j.pupt.2008.12.007
Burgess JK, et al. Tissue and Matrix Influences On Airway Smooth Muscle Function. Pulm Pharmacol Ther. 2009;22(5):379-87. PubMed PMID: 19135163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue and matrix influences on airway smooth muscle function. AU - Burgess,Janette K, AU - Ceresa,Claudia, AU - Johnson,Simon R, AU - Kanabar,Varsha, AU - Moir,Lyn M, AU - Nguyen,Trang T B, AU - Oliver,Brian G G, AU - Schuliga,Michael, AU - Ward,Jane, Y1 - 2008/12/24/ PY - 2008/05/02/received PY - 2008/11/14/revised PY - 2008/12/10/accepted PY - 2009/1/13/entrez PY - 2009/1/13/pubmed PY - 2010/1/6/medline SP - 379 EP - 87 JF - Pulmonary pharmacology & therapeutics JO - Pulm Pharmacol Ther VL - 22 IS - 5 N2 - Asthma is characterized by structural changes in the airways - airway remodelling. These changes include an increase in the bulk of the airway smooth muscle (ASM) and alterations in the profile of extracellular matrix (ECM) proteins in the airway wall. The mechanisms leading to airway remodelling are not well understood. ASM cells have the potential to play a key role in these processes through the production and release of ECM proteins. The ASM cells and ECM proteins are each able to influence the behaviour and characteristics of the other. The modified ECM profile in the asthmatic airway may contribute to the altered behaviour of the ASM cells, such responses to ECM proteins are modulated through the cell surface expression of integrin receptors. ASM cells from asthmatic individuals express different levels of some integrin subunits compared to nonasthmatic ASM cells, which have the potential to further influence their responses to the ECM proteins in the airways. ECM homeostasis requires the presence and activation of matrix metalloproteinases and their tissue inhibitors, which in turn modulate the interaction of the ASM cells and the ECM proteins. Furthermore, the complex interactions of the ASM cells and the ECM in the asthmatic airways and the role played by external stimuli, such as viral infections, to modulate airway remodelling are currently unknown. This review summarises our current understanding of the influence of the ECM on ASM function. SN - 1522-9629 UR - https://www.unboundmedicine.com/medline/citation/19135163/Tissue_and_matrix_influences_on_airway_smooth_muscle_function_ DB - PRIME DP - Unbound Medicine ER -