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New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins.
J Inorg Biochem. 2009 Mar; 103(3):381-8.JI

Abstract

Mimetics of antioxidant enzymes such as superoxide dismutases (SOD) or catalases are reported as potential new drugs able to reduce oxidative stress damage. In particular, manganese(III) complexes of salen-type ligands have been studied as both SOD and catalase mimetics. In this paper, we report the synthesis of two novel conjugates of salen-type ligands with the beta-cyclodextrin, the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(salicylidene))]-beta-cyclodextrin and the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(3-methoxysalicylidene))]-beta-cyclodextrin, their spectroscopic characterization, and the synthesis and the characterization of their manganese(III) complexes. The SOD-like activity of the metal complexes was investigated by the indirect Fridovich method. The catalase like activity was tested using a Clark-type oxygen electrode. The peroxidase activity was tested using the ABTS (2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay. The glycoconjugation of salen-manganese(III) complexes yields compounds with enhanced SOD activity. These complexes also show catalase and peroxidase activities higher than the simple salen complexes (EUK 113 and EUK 108).

Authors+Show Affiliations

Dipartimento di Scienze Chimiche, Università di Catania, viale A. Doria 8, 95125 Catania, Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19135258

Citation

Lanza, Valeria, and Graziella Vecchio. "New Conjugates of Superoxide Dismutase/catalase Mimetics With Cyclodestrins." Journal of Inorganic Biochemistry, vol. 103, no. 3, 2009, pp. 381-8.
Lanza V, Vecchio G. New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins. J Inorg Biochem. 2009;103(3):381-8.
Lanza, V., & Vecchio, G. (2009). New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins. Journal of Inorganic Biochemistry, 103(3), 381-8. https://doi.org/10.1016/j.jinorgbio.2008.11.017
Lanza V, Vecchio G. New Conjugates of Superoxide Dismutase/catalase Mimetics With Cyclodestrins. J Inorg Biochem. 2009;103(3):381-8. PubMed PMID: 19135258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins. AU - Lanza,Valeria, AU - Vecchio,Graziella, Y1 - 2008/12/07/ PY - 2008/07/18/received PY - 2008/11/21/revised PY - 2008/11/24/accepted PY - 2009/1/13/entrez PY - 2009/1/13/pubmed PY - 2009/4/11/medline SP - 381 EP - 8 JF - Journal of inorganic biochemistry JO - J Inorg Biochem VL - 103 IS - 3 N2 - Mimetics of antioxidant enzymes such as superoxide dismutases (SOD) or catalases are reported as potential new drugs able to reduce oxidative stress damage. In particular, manganese(III) complexes of salen-type ligands have been studied as both SOD and catalase mimetics. In this paper, we report the synthesis of two novel conjugates of salen-type ligands with the beta-cyclodextrin, the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(salicylidene))]-beta-cyclodextrin and the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(3-methoxysalicylidene))]-beta-cyclodextrin, their spectroscopic characterization, and the synthesis and the characterization of their manganese(III) complexes. The SOD-like activity of the metal complexes was investigated by the indirect Fridovich method. The catalase like activity was tested using a Clark-type oxygen electrode. The peroxidase activity was tested using the ABTS (2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay. The glycoconjugation of salen-manganese(III) complexes yields compounds with enhanced SOD activity. These complexes also show catalase and peroxidase activities higher than the simple salen complexes (EUK 113 and EUK 108). SN - 1873-3344 UR - https://www.unboundmedicine.com/medline/citation/19135258/New_conjugates_of_superoxide_dismutase/catalase_mimetics_with_cyclodestrins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0162-0134(08)00294-8 DB - PRIME DP - Unbound Medicine ER -