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Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty.
Fertil Steril. 2010 Mar 01; 93(4):1185-91.FS

Abstract

OBJECTIVE

To assess the prevalence of polycystic ovary syndrome (PCOS) in a cohort of young women with previous idiopathic central precocious puberty (ICPP) at least 3 years after menarche, and to look for any predictive factors of PCOS at the time ICPP was diagnosed.

DESIGN

Longitudinal study.

SETTING

Pediatrics unit, Verona, Italy.

PATIENT(S)

Forty-six young women (18.1 +/- 3.0 years) who had been treated with GnRH analogues during childhood, observed at gynecologic age of 6.23 +/- 3.3 years.

INTERVENTION(S)

Semistructured interview concerning cycles, physical exam, blood sampling, and transabdominal pelvic ultrasound.

MAIN OUTCOME MEASURE(S)

Oligomenorrhea, LH, FSH, E(2), T, DHEAS, free T, delta4-androstenedione, 17-OHP, P, polycystic ovary morphology (PCOM).

RESULT(S)

Fifteen percent of the young women had oligomenorrhea, 28% clinical hyperandrogenism, 48% biochemical hyperandrogenism, and 37% PCOM. A total of 32% of the patients had PCOS according to the Rotterdam definition and 30% had PCOS according to the Androgen Exess Society. The prevalent phenotype of PCOS was characterized by clinical and/or biochemical hyperandrogenism and PCOM. We did not find any predictive factors for PCOS at the time ICPP was diagnosed.

CONCLUSION(S)

Patients with ICCP are prone to developing PCOS. The prominent phenotype in this cohort was PCOM associated with clinical and/or biochemical hyperandrogenism. Further follow-ups of these young adult patients will clarify whether this phenotype persists and if it will have important long-term implications regarding increased risk of infertility or metabolic complications.

Authors+Show Affiliations

Pediatrics Unit, Department of Mother and Child, Biology-Genetics, University of Verona, P.le L.A. Scuro, 10, 37134 Verona, Italy. robertofranceschi@yahoo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19135667

Citation

Franceschi, Roberto, et al. "Prevalence of Polycystic Ovary Syndrome in Young Women Who Had Idiopathic Central Precocious Puberty." Fertility and Sterility, vol. 93, no. 4, 2010, pp. 1185-91.
Franceschi R, Gaudino R, Marcolongo A, et al. Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty. Fertil Steril. 2010;93(4):1185-91.
Franceschi, R., Gaudino, R., Marcolongo, A., Gallo, M. C., Rossi, L., Antoniazzi, F., & Tatò, L. (2010). Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty. Fertility and Sterility, 93(4), 1185-91. https://doi.org/10.1016/j.fertnstert.2008.11.016
Franceschi R, et al. Prevalence of Polycystic Ovary Syndrome in Young Women Who Had Idiopathic Central Precocious Puberty. Fertil Steril. 2010 Mar 1;93(4):1185-91. PubMed PMID: 19135667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty. AU - Franceschi,Roberto, AU - Gaudino,Rossella, AU - Marcolongo,Alma, AU - Gallo,Maria Chiara, AU - Rossi,Luigi, AU - Antoniazzi,Franco, AU - Tatò,Luciano, Y1 - 2009/01/09/ PY - 2008/07/19/received PY - 2008/10/28/revised PY - 2008/11/11/accepted PY - 2009/1/13/entrez PY - 2009/1/13/pubmed PY - 2010/4/2/medline SP - 1185 EP - 91 JF - Fertility and sterility JO - Fertil Steril VL - 93 IS - 4 N2 - OBJECTIVE: To assess the prevalence of polycystic ovary syndrome (PCOS) in a cohort of young women with previous idiopathic central precocious puberty (ICPP) at least 3 years after menarche, and to look for any predictive factors of PCOS at the time ICPP was diagnosed. DESIGN: Longitudinal study. SETTING: Pediatrics unit, Verona, Italy. PATIENT(S): Forty-six young women (18.1 +/- 3.0 years) who had been treated with GnRH analogues during childhood, observed at gynecologic age of 6.23 +/- 3.3 years. INTERVENTION(S): Semistructured interview concerning cycles, physical exam, blood sampling, and transabdominal pelvic ultrasound. MAIN OUTCOME MEASURE(S): Oligomenorrhea, LH, FSH, E(2), T, DHEAS, free T, delta4-androstenedione, 17-OHP, P, polycystic ovary morphology (PCOM). RESULT(S): Fifteen percent of the young women had oligomenorrhea, 28% clinical hyperandrogenism, 48% biochemical hyperandrogenism, and 37% PCOM. A total of 32% of the patients had PCOS according to the Rotterdam definition and 30% had PCOS according to the Androgen Exess Society. The prevalent phenotype of PCOS was characterized by clinical and/or biochemical hyperandrogenism and PCOM. We did not find any predictive factors for PCOS at the time ICPP was diagnosed. CONCLUSION(S): Patients with ICCP are prone to developing PCOS. The prominent phenotype in this cohort was PCOM associated with clinical and/or biochemical hyperandrogenism. Further follow-ups of these young adult patients will clarify whether this phenotype persists and if it will have important long-term implications regarding increased risk of infertility or metabolic complications. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19135667/Prevalence_of_polycystic_ovary_syndrome_in_young_women_who_had_idiopathic_central_precocious_puberty_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)04578-0 DB - PRIME DP - Unbound Medicine ER -