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Lung function impairment and metabolic syndrome: the critical role of abdominal obesity.

Abstract

RATIONALE

Increased risk for cardiovascular morbidity and mortality has been related to both lung function impairment and metabolic syndrome. Data on the relationship between lung function and metabolic syndrome are sparse.

OBJECTIVES

To investigate risk for lung function impairment according to metabolic syndrome traits.

METHODS

This cross-sectional population-based study included 121,965 men and women examined at the Paris Investigations Préventives et Cliniques Center between 1999 and 2006. The lower limit of normal was used to define lung function impairment (FEV(1) or FVC < lower limit of normal). Metabolic syndrome was assessed according to the American Heart Association/National Heart, Lung, and Blood Institute statement.

MEASUREMENTS AND MAIN RESULTS

We used a logistic regression model and principal component analysis to investigate the differential associations between lung function impairment and specific components of metabolic syndrome. Lung function impairment was associated with metabolic syndrome (prevalence = 15.0%) independently of age, sex, smoking status, alcohol consumption, educational level, body mass index, leisure-time physical activity, and cardiovascular disease history (odds ratio [OR] [95% confidence interval], 1.28 [1.20-1.37] and OR, 1.41 [1.31-1.51] for FEV(1) and FVC, respectively). Three factors were identified from factor analysis: "lipids" (low high-density lipoprotein cholesterol, high triglycerides), "glucose-blood pressure" (high fasting glycemia, high blood pressure), and "abdominal obesity" (large waist circumference). All factors were inversely related to lung function, but abdominal obesity was the strongest predictor of lung function impairment (OR, 1.94 [1.80-2.09] and OR, 2.11 [1.95-2.29], for FEV(1) and FVC, respectively). Similar results were obtained for women and men.

CONCLUSIONS

We found a positive independent relationship between lung function impairment and metabolic syndrome in both sexes, predominantly due to abdominal obesity. Further studies are required to clarify the underlying mechanisms.

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  • Authors+Show Affiliations

    ,

    INSERM U700, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, BP 416, 75018 Paris, France. nathalie.leone@inserm.fr

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Blood Glucose
    Blood Pressure
    Cholesterol, LDL
    Cross-Sectional Studies
    Female
    Forced Expiratory Volume
    Humans
    Logistic Models
    Male
    Metabolic Syndrome
    Middle Aged
    Obesity
    Principal Component Analysis
    Sex Factors
    Triglycerides
    Vital Capacity
    Waist Circumference
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19136371

    Citation

    Leone, Nathalie, et al. "Lung Function Impairment and Metabolic Syndrome: the Critical Role of Abdominal Obesity." American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 6, 2009, pp. 509-16.
    Leone N, Courbon D, Thomas F, et al. Lung function impairment and metabolic syndrome: the critical role of abdominal obesity. Am J Respir Crit Care Med. 2009;179(6):509-16.
    Leone, N., Courbon, D., Thomas, F., Bean, K., Jégo, B., Leynaert, B., ... Zureik, M. (2009). Lung function impairment and metabolic syndrome: the critical role of abdominal obesity. American Journal of Respiratory and Critical Care Medicine, 179(6), pp. 509-16. doi:10.1164/rccm.200807-1195OC.
    Leone N, et al. Lung Function Impairment and Metabolic Syndrome: the Critical Role of Abdominal Obesity. Am J Respir Crit Care Med. 2009 Mar 15;179(6):509-16. PubMed PMID: 19136371.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lung function impairment and metabolic syndrome: the critical role of abdominal obesity. AU - Leone,Nathalie, AU - Courbon,Dominique, AU - Thomas,Frédérique, AU - Bean,Kathy, AU - Jégo,Bertrand, AU - Leynaert,Bénédicte, AU - Guize,Louis, AU - Zureik,Mahmoud, Y1 - 2009/01/08/ PY - 2009/1/13/entrez PY - 2009/1/13/pubmed PY - 2009/4/1/medline SP - 509 EP - 16 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 179 IS - 6 N2 - RATIONALE: Increased risk for cardiovascular morbidity and mortality has been related to both lung function impairment and metabolic syndrome. Data on the relationship between lung function and metabolic syndrome are sparse. OBJECTIVES: To investigate risk for lung function impairment according to metabolic syndrome traits. METHODS: This cross-sectional population-based study included 121,965 men and women examined at the Paris Investigations Préventives et Cliniques Center between 1999 and 2006. The lower limit of normal was used to define lung function impairment (FEV(1) or FVC < lower limit of normal). Metabolic syndrome was assessed according to the American Heart Association/National Heart, Lung, and Blood Institute statement. MEASUREMENTS AND MAIN RESULTS: We used a logistic regression model and principal component analysis to investigate the differential associations between lung function impairment and specific components of metabolic syndrome. Lung function impairment was associated with metabolic syndrome (prevalence = 15.0%) independently of age, sex, smoking status, alcohol consumption, educational level, body mass index, leisure-time physical activity, and cardiovascular disease history (odds ratio [OR] [95% confidence interval], 1.28 [1.20-1.37] and OR, 1.41 [1.31-1.51] for FEV(1) and FVC, respectively). Three factors were identified from factor analysis: "lipids" (low high-density lipoprotein cholesterol, high triglycerides), "glucose-blood pressure" (high fasting glycemia, high blood pressure), and "abdominal obesity" (large waist circumference). All factors were inversely related to lung function, but abdominal obesity was the strongest predictor of lung function impairment (OR, 1.94 [1.80-2.09] and OR, 2.11 [1.95-2.29], for FEV(1) and FVC, respectively). Similar results were obtained for women and men. CONCLUSIONS: We found a positive independent relationship between lung function impairment and metabolic syndrome in both sexes, predominantly due to abdominal obesity. Further studies are required to clarify the underlying mechanisms. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/19136371/Lung_function_impairment_and_metabolic_syndrome:_the_critical_role_of_abdominal_obesity_ L2 - http://www.atsjournals.org/doi/full/10.1164/rccm.200807-1195OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -