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[Hemodynamic response to somatostatin at rest and during sympathetic activation in idiopathic orthostatic hypotension].
Cardiologia. 1991 Mar; 36(3):199-206.C

Abstract

Idiopathic orthostatic hypotension (IOH) represents a degenerative disorder of the peripheral nervous system characterized by low values of arterial blood pressure during orthostatism, with reduction in serum catecholamines. Since treatment of symptomatic IOH has been unsatisfactory till now, we studied the hemodynamic response to somatostatin (S) (Octreotide, 100 micrograms sc) at rest (R) and during sympathetic activation (tilting, T) by means of 2D and/or color Doppler echocardiography, in 5 ambulatory IOH patients (4M, 1F; aged 65 +/- 5 years), with simultaneous recording of blood pressure and heart rate. Post-S, an increased blood pressure was evident during T without heart rate modifications (pre- vs post-S, SAP: 92 +/- 9 vs 148 +/- 12; DAP: 61 +/- 4 vs 90 +/- 9 mmHg; p less than 0.05), while systolic echo parameters did not change significantly. Doppler aortic velocity curve showed during T a reduction of Vmax (pre- vs post-S: 0.98 +/- 0.09 vs 0.73 +/- 0.03 m/s; p less than 0.05) and of cardiac output, due to unchanged preload. Pre-S, at rest, Doppler mitral velocity curve presented a normal E/A ratio as in normal subjects, with a reduced E peak and an increased A peak post-S, indirect signs of increased afterload. Pre-S, E and A peak velocities underwent progressive decrease during T, markedly more evident post-S. Total peripheral resistance, at rest and during T, increased post-S too (pre- vs post-S, rest: 2406 +/- 267 vs 3162 +/- 599; T: 1634 +/- 201 vs 2784 +/- 425 dyne*s/cm-5; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Frisinghelli A
Patologia Speciale Medica, Università degli Studi, Milano.
Crema C
No affiliation info available
Bevilacqua M
No affiliation info available
Chebat E
No affiliation info available
Turiel M
No affiliation info available

MeSH

AgedAged, 80 and overBlood PressureEchocardiography, DopplerFemaleHeart RateHemodynamicsHumansHypotension, OrthostaticMaleMiddle AgedOctreotideSympathetic Nervous System

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

1913713

Citation

Frisinghelli, A, et al. "[Hemodynamic Response to Somatostatin at Rest and During Sympathetic Activation in Idiopathic Orthostatic Hypotension]." Cardiologia (Rome, Italy), vol. 36, no. 3, 1991, pp. 199-206.
Frisinghelli A, Crema C, Bevilacqua M, et al. [Hemodynamic response to somatostatin at rest and during sympathetic activation in idiopathic orthostatic hypotension]. Cardiologia. 1991;36(3):199-206.
Frisinghelli, A., Crema, C., Bevilacqua, M., Chebat, E., & Turiel, M. (1991). [Hemodynamic response to somatostatin at rest and during sympathetic activation in idiopathic orthostatic hypotension]. Cardiologia (Rome, Italy), 36(3), 199-206.
Frisinghelli A, et al. [Hemodynamic Response to Somatostatin at Rest and During Sympathetic Activation in Idiopathic Orthostatic Hypotension]. Cardiologia. 1991;36(3):199-206. PubMed PMID: 1913713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hemodynamic response to somatostatin at rest and during sympathetic activation in idiopathic orthostatic hypotension]. AU - Frisinghelli,A, AU - Crema,C, AU - Bevilacqua,M, AU - Chebat,E, AU - Turiel,M, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 199 EP - 206 JF - Cardiologia (Rome, Italy) JO - Cardiologia VL - 36 IS - 3 N2 - Idiopathic orthostatic hypotension (IOH) represents a degenerative disorder of the peripheral nervous system characterized by low values of arterial blood pressure during orthostatism, with reduction in serum catecholamines. Since treatment of symptomatic IOH has been unsatisfactory till now, we studied the hemodynamic response to somatostatin (S) (Octreotide, 100 micrograms sc) at rest (R) and during sympathetic activation (tilting, T) by means of 2D and/or color Doppler echocardiography, in 5 ambulatory IOH patients (4M, 1F; aged 65 +/- 5 years), with simultaneous recording of blood pressure and heart rate. Post-S, an increased blood pressure was evident during T without heart rate modifications (pre- vs post-S, SAP: 92 +/- 9 vs 148 +/- 12; DAP: 61 +/- 4 vs 90 +/- 9 mmHg; p less than 0.05), while systolic echo parameters did not change significantly. Doppler aortic velocity curve showed during T a reduction of Vmax (pre- vs post-S: 0.98 +/- 0.09 vs 0.73 +/- 0.03 m/s; p less than 0.05) and of cardiac output, due to unchanged preload. Pre-S, at rest, Doppler mitral velocity curve presented a normal E/A ratio as in normal subjects, with a reduced E peak and an increased A peak post-S, indirect signs of increased afterload. Pre-S, E and A peak velocities underwent progressive decrease during T, markedly more evident post-S. Total peripheral resistance, at rest and during T, increased post-S too (pre- vs post-S, rest: 2406 +/- 267 vs 3162 +/- 599; T: 1634 +/- 201 vs 2784 +/- 425 dyne*s/cm-5; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0393-1978 UR - https://www.unboundmedicine.com/medline/citation/1913713/[Hemodynamic_response_to_somatostatin_at_rest_and_during_sympathetic_activation_in_idiopathic_orthostatic_hypotension]_ DB - PRIME DP - Unbound Medicine ER -