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[Seasonal changes in the composition of the titin isoforms in muscles of hibernating ground squirrels].

Abstract

An electrophoretic study of changes in the content of intact titin isoforms, N2B-, N2BA-, N2A-titins and T2 in skeletal and cardiac muscles of ground squirrel (Spermophillus undulatus) in different periods: summer activity, autumn activity, hibernation, arousal, and winter activity has been carried out. In atriums and ventricles of autumn activity ground squirrels, an increase (approximately 1.5 times) in the N2BA-to-N2B ratio in comparison with that in cardiac muscle of summer activity ground squirrels has been observed. During hibernation, the decrease in the relative content of N2B,- N2BA-titins and T2 in cardiac muscle and of N2A-titin and T2 in skeletal muscles has been tested against the background of preservation of the relative amount of intact titin isoforms. During arousal of ground squirrel and in short-time period of winter activity, a rapid restoration in the content of N2B,- N2BA-, N2A-titins and T2 in muscles has been observed. In this case, in cardiac muscle of hibernating, arousing and winter active ground squirrels, the increased N2BA-to-N2B ratio has been preserved. The changes in the titin content are discussed in the context of adaptation of ground squirrels to hibernation.

Authors

, ,

Source

Biofizika 53:6 pg 1066-72

MeSH

Animals
Connectin
Electrophoresis, Polyacrylamide Gel
Hibernation
Muscle Proteins
Muscle, Skeletal
Myocardium
Protein Isoforms
Protein Kinases
Sciuridae
Seasons

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

rus

PubMed ID

19137694

Citation

Vikhliantsev, I M., et al. "[Seasonal Changes in the Composition of the Titin Isoforms in Muscles of Hibernating Ground Squirrels]." Biofizika, vol. 53, no. 6, 2008, pp. 1066-72.
Vikhliantsev IM, Karaduleva EV, Podlubnaia ZA. [Seasonal changes in the composition of the titin isoforms in muscles of hibernating ground squirrels]. Biofizika. 2008;53(6):1066-72.
Vikhliantsev, I. M., Karaduleva, E. V., & Podlubnaia, Z. A. (2008). [Seasonal changes in the composition of the titin isoforms in muscles of hibernating ground squirrels]. Biofizika, 53(6), pp. 1066-72.
Vikhliantsev IM, Karaduleva EV, Podlubnaia ZA. [Seasonal Changes in the Composition of the Titin Isoforms in Muscles of Hibernating Ground Squirrels]. Biofizika. 2008;53(6):1066-72. PubMed PMID: 19137694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Seasonal changes in the composition of the titin isoforms in muscles of hibernating ground squirrels]. AU - Vikhliantsev,I M, AU - Karaduleva,E V, AU - Podlubnaia,Z A, PY - 2009/1/14/entrez PY - 2009/1/14/pubmed PY - 2009/3/7/medline SP - 1066 EP - 72 JF - Biofizika JO - Biofizika VL - 53 IS - 6 N2 - An electrophoretic study of changes in the content of intact titin isoforms, N2B-, N2BA-, N2A-titins and T2 in skeletal and cardiac muscles of ground squirrel (Spermophillus undulatus) in different periods: summer activity, autumn activity, hibernation, arousal, and winter activity has been carried out. In atriums and ventricles of autumn activity ground squirrels, an increase (approximately 1.5 times) in the N2BA-to-N2B ratio in comparison with that in cardiac muscle of summer activity ground squirrels has been observed. During hibernation, the decrease in the relative content of N2B,- N2BA-titins and T2 in cardiac muscle and of N2A-titin and T2 in skeletal muscles has been tested against the background of preservation of the relative amount of intact titin isoforms. During arousal of ground squirrel and in short-time period of winter activity, a rapid restoration in the content of N2B,- N2BA-, N2A-titins and T2 in muscles has been observed. In this case, in cardiac muscle of hibernating, arousing and winter active ground squirrels, the increased N2BA-to-N2B ratio has been preserved. The changes in the titin content are discussed in the context of adaptation of ground squirrels to hibernation. SN - 0006-3029 UR - https://www.unboundmedicine.com/medline/citation/19137694/[Seasonal_changes_in_the_composition_of_the_titin_isoforms_in_muscles_of_hibernating_ground_squirrels]_ DB - PRIME DP - Unbound Medicine ER -