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Adult patients with moderate atopic dermatitis: tacrolimus ointment versus pimecrolimus cream.
J Drugs Dermatol. 2008 Dec; 7(12):1153-8.JD

Abstract

The objective of this study was to compare the efficacy and safety of tacrolimus ointment and pimecrolimus cream in adults with moderate atopic dermatitis (AD). A randomized, investigator-blinded, 6-week, multicenter study enrolled patients (> or =16 years) with mild to very severe AD. Patients with moderate AD at baseline were analyzed. At study completion, tacrolimus ointment-treated patients had significantly greater improvement in Eczema Area Severity Index score compared with pimecrolimus cream-treated patients (59% versus. 43% reduction, respectively; P=.01). Significantly more tacrolimus ointment-treated patients than pimecrolimus cream-treated patients improved by 1 or more grades on the Investigators' Global Atopic Dermatitis Assessment (P<.02). A total of 5 pimecrolimus cream-treated patients discontinued the study early due to lack of efficacy compared with no tacrolimus ointment-treated patients (P=.02). Overall, reported adverse events occurred at a similar frequency for both treatment groups. Tacrolimus ointment is more effective than pimecrolimus cream in the management of adults with moderate AD.

Authors+Show Affiliations

Dermatology Treatment and Research Center and Baylor University Medical Center, Dallas,TX, USA. DrA@DermCenter.usNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19137769

Citation

Abramovits, William, et al. "Adult Patients With Moderate Atopic Dermatitis: Tacrolimus Ointment Versus Pimecrolimus Cream." Journal of Drugs in Dermatology : JDD, vol. 7, no. 12, 2008, pp. 1153-8.
Abramovits W, Fleischer AB, Jaracz E, et al. Adult patients with moderate atopic dermatitis: tacrolimus ointment versus pimecrolimus cream. J Drugs Dermatol. 2008;7(12):1153-8.
Abramovits, W., Fleischer, A. B., Jaracz, E., & Breneman, D. (2008). Adult patients with moderate atopic dermatitis: tacrolimus ointment versus pimecrolimus cream. Journal of Drugs in Dermatology : JDD, 7(12), 1153-8.
Abramovits W, et al. Adult Patients With Moderate Atopic Dermatitis: Tacrolimus Ointment Versus Pimecrolimus Cream. J Drugs Dermatol. 2008;7(12):1153-8. PubMed PMID: 19137769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adult patients with moderate atopic dermatitis: tacrolimus ointment versus pimecrolimus cream. AU - Abramovits,William, AU - Fleischer,Alan B,Jr AU - Jaracz,Eileen, AU - Breneman,Debra, PY - 2009/1/14/entrez PY - 2009/1/14/pubmed PY - 2009/2/20/medline SP - 1153 EP - 8 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 7 IS - 12 N2 - The objective of this study was to compare the efficacy and safety of tacrolimus ointment and pimecrolimus cream in adults with moderate atopic dermatitis (AD). A randomized, investigator-blinded, 6-week, multicenter study enrolled patients (> or =16 years) with mild to very severe AD. Patients with moderate AD at baseline were analyzed. At study completion, tacrolimus ointment-treated patients had significantly greater improvement in Eczema Area Severity Index score compared with pimecrolimus cream-treated patients (59% versus. 43% reduction, respectively; P=.01). Significantly more tacrolimus ointment-treated patients than pimecrolimus cream-treated patients improved by 1 or more grades on the Investigators' Global Atopic Dermatitis Assessment (P<.02). A total of 5 pimecrolimus cream-treated patients discontinued the study early due to lack of efficacy compared with no tacrolimus ointment-treated patients (P=.02). Overall, reported adverse events occurred at a similar frequency for both treatment groups. Tacrolimus ointment is more effective than pimecrolimus cream in the management of adults with moderate AD. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/19137769/Adult_patients_with_moderate_atopic_dermatitis:_tacrolimus_ointment_versus_pimecrolimus_cream_ L2 - http://www.diseaseinfosearch.org/result/9652 DB - PRIME DP - Unbound Medicine ER -