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Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study.
J Bone Miner Res 2009; 24(6):1086-94JB

Abstract

In vitro and in vivo studies suggest that carotenoids may inhibit bone resorption, yet no previous study has examined individual carotenoid intake (other than beta-carotene) and the risk of fracture. We evaluated associations of total and individual carotenoid intake (alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein + zeaxanthin) with incident hip fracture and nonvertebral osteoporotic fracture. Three hundred seventy men and 576 women (mean age, 75 +/- 5 yr) from the Framingham Osteoporosis Study completed a food frequency questionnaire (FFQ) in 1988-1989 and were followed for hip fracture until 2005 and nonvertebral fracture until 2003. Tertiles of carotenoid intake were created from estimates obtained using the Willett FFQ adjusting for total energy (residual method). HRs were estimated using Cox-proportional hazards regression, adjusting for sex, age, body mass index, height, total energy, calcium and vitamin D intake, physical activity, alcohol, smoking, multivitamin use, and current estrogen use. A total of 100 hip fractures occurred over 17 yr of follow-up. Subjects in the highest tertile of total carotenoid intake had lower risk of hip fracture (p = 0.02). Subjects with higher lycopene intake had lower risk of hip fracture (p =0.01) and nonvertebral fracture (p = 0.02). A weak protective trend was observed for total beta-carotene for hip fracture alone, but associations did not reach statistical significance (p = 0.10). No significant associations were observed with alpha-carotene, beta-cryptoxanthin, or lutein + zeaxanthin. These results suggest a protective role of several carotenoids for bone health in older adults.

Authors+Show Affiliations

Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111-1524, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19138129

Citation

Sahni, Shivani, et al. "Protective Effect of Total Carotenoid and Lycopene Intake On the Risk of Hip Fracture: a 17-year Follow-up From the Framingham Osteoporosis Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 24, no. 6, 2009, pp. 1086-94.
Sahni S, Hannan MT, Blumberg J, et al. Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. J Bone Miner Res. 2009;24(6):1086-94.
Sahni, S., Hannan, M. T., Blumberg, J., Cupples, L. A., Kiel, D. P., & Tucker, K. L. (2009). Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 24(6), pp. 1086-94. doi:10.1359/jbmr.090102.
Sahni S, et al. Protective Effect of Total Carotenoid and Lycopene Intake On the Risk of Hip Fracture: a 17-year Follow-up From the Framingham Osteoporosis Study. J Bone Miner Res. 2009;24(6):1086-94. PubMed PMID: 19138129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. AU - Sahni,Shivani, AU - Hannan,Marian T, AU - Blumberg,Jeffrey, AU - Cupples,L Adrienne, AU - Kiel,Douglas P, AU - Tucker,Katherine L, PY - 2009/1/14/entrez PY - 2009/1/14/pubmed PY - 2009/8/14/medline SP - 1086 EP - 94 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 24 IS - 6 N2 - In vitro and in vivo studies suggest that carotenoids may inhibit bone resorption, yet no previous study has examined individual carotenoid intake (other than beta-carotene) and the risk of fracture. We evaluated associations of total and individual carotenoid intake (alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein + zeaxanthin) with incident hip fracture and nonvertebral osteoporotic fracture. Three hundred seventy men and 576 women (mean age, 75 +/- 5 yr) from the Framingham Osteoporosis Study completed a food frequency questionnaire (FFQ) in 1988-1989 and were followed for hip fracture until 2005 and nonvertebral fracture until 2003. Tertiles of carotenoid intake were created from estimates obtained using the Willett FFQ adjusting for total energy (residual method). HRs were estimated using Cox-proportional hazards regression, adjusting for sex, age, body mass index, height, total energy, calcium and vitamin D intake, physical activity, alcohol, smoking, multivitamin use, and current estrogen use. A total of 100 hip fractures occurred over 17 yr of follow-up. Subjects in the highest tertile of total carotenoid intake had lower risk of hip fracture (p = 0.02). Subjects with higher lycopene intake had lower risk of hip fracture (p =0.01) and nonvertebral fracture (p = 0.02). A weak protective trend was observed for total beta-carotene for hip fracture alone, but associations did not reach statistical significance (p = 0.10). No significant associations were observed with alpha-carotene, beta-cryptoxanthin, or lutein + zeaxanthin. These results suggest a protective role of several carotenoids for bone health in older adults. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/19138129/Protective_effect_of_total_carotenoid_and_lycopene_intake_on_the_risk_of_hip_fracture:_a_17_year_follow_up_from_the_Framingham_Osteoporosis_Study_ L2 - https://doi.org/10.1359/jbmr.090102 DB - PRIME DP - Unbound Medicine ER -