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Correlation of anatomy and function in medulla oblongata infarction.
Eur J Neurol. 2009 Feb; 16(2):201-4.EJ

Abstract

BACKGROUND

A presentation of all aspects of the dorsolateral medulla oblongata syndrome is clinically very rare to find. In most cases patients present with fragmentary symptoms, e.g. ipsilateral axial lateropulsion, nystagmus, dysarthria, dysphagia or hemiataxia. However, the clinical presentation and lesion anatomy at the level of the medulla oblongata is still unsatisfactory. The aim of this study was to correlate the functional deficit with structural MRI-data.

METHODS

We included thirteen patients (eight male, five female, mean age 65.5) with medulla oblongata infarction with clinically predominant ipsilateral axial lateropulsion and correlated clinical with structural deficits.

RESULTS

Magnetic resonance imaging lesion mapping demonstrated ipsilateral axial lateropulsion to result from lesions of the spinocerebellar tract, the inferior cerebellar peduncle or the inferior vestibular nucleus. Nystagmus was associated with lesions of the inferior vestibular nucleus, dissociated sensory loss with the spinothalamic tract and hemiataxia with the spinocerebellar tract.

CONCLUSIONS

Correlating dysfunction and lesion anatomy is a promising approach to enhance our knowledge on medulla oblongata topography.

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Authors+Show Affiliations

Eggers C
Department of Neurology, University of Cologne, Cologne, Germany.
Fink GR
No affiliation info available
Möller-Hartmann W
No affiliation info available
Nowak DA
No affiliation info available

MeSH

AgedAged, 80 and overBrain Stem InfarctionsFemaleHumansMagnetic Resonance ImagingMaleMedulla OblongataMiddle AgedRadiography

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19138337

Citation

Eggers, C, et al. "Correlation of Anatomy and Function in Medulla Oblongata Infarction." European Journal of Neurology, vol. 16, no. 2, 2009, pp. 201-4.
Eggers C, Fink GR, Möller-Hartmann W, et al. Correlation of anatomy and function in medulla oblongata infarction. Eur J Neurol. 2009;16(2):201-4.
Eggers, C., Fink, G. R., Möller-Hartmann, W., & Nowak, D. A. (2009). Correlation of anatomy and function in medulla oblongata infarction. European Journal of Neurology, 16(2), 201-4. https://doi.org/10.1111/j.1468-1331.2008.02381.x
Eggers C, et al. Correlation of Anatomy and Function in Medulla Oblongata Infarction. Eur J Neurol. 2009;16(2):201-4. PubMed PMID: 19138337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of anatomy and function in medulla oblongata infarction. AU - Eggers,C, AU - Fink,G R, AU - Möller-Hartmann,W, AU - Nowak,D A, Y1 - 2008/12/09/ PY - 2009/1/14/entrez PY - 2009/1/14/pubmed PY - 2009/4/29/medline SP - 201 EP - 4 JF - European journal of neurology JO - Eur J Neurol VL - 16 IS - 2 N2 - BACKGROUND: A presentation of all aspects of the dorsolateral medulla oblongata syndrome is clinically very rare to find. In most cases patients present with fragmentary symptoms, e.g. ipsilateral axial lateropulsion, nystagmus, dysarthria, dysphagia or hemiataxia. However, the clinical presentation and lesion anatomy at the level of the medulla oblongata is still unsatisfactory. The aim of this study was to correlate the functional deficit with structural MRI-data. METHODS: We included thirteen patients (eight male, five female, mean age 65.5) with medulla oblongata infarction with clinically predominant ipsilateral axial lateropulsion and correlated clinical with structural deficits. RESULTS: Magnetic resonance imaging lesion mapping demonstrated ipsilateral axial lateropulsion to result from lesions of the spinocerebellar tract, the inferior cerebellar peduncle or the inferior vestibular nucleus. Nystagmus was associated with lesions of the inferior vestibular nucleus, dissociated sensory loss with the spinothalamic tract and hemiataxia with the spinocerebellar tract. CONCLUSIONS: Correlating dysfunction and lesion anatomy is a promising approach to enhance our knowledge on medulla oblongata topography. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/19138337/Correlation_of_anatomy_and_function_in_medulla_oblongata_infarction_ L2 - https://doi.org/10.1111/j.1468-1331.2008.02381.x DB - PRIME DP - Unbound Medicine ER -