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Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17; 33(2):308-11.PN

Abstract

OBJECTIVE

The aim of this study was to investigate the effects of yokukansan (YKS) on the behavioral and psychological symptoms of dementia (BPSD) in elderly patients with Alzheimer's disease (AD).

METHODS

Fifteen patients with AD (mean age: 80.2+/-4.0 years) participated in the study. The Mini-Mental State Examination (MMSE) was used for the assessment of cognitive function. BPSD were evaluated using the Neuropsychiatric Inventory (NPI). The Barthel Index was used for the assessment for the activities of daily living (ADL). The treatment with YKS along with sulpiride, a dopamine D(2) selective antipsychotic, was performed for 12 weeks.

RESULTS

Fourteen patients completed the trial. After the 12 weeks of treatment with YKS, significant improvement of the mean NPI score was observed while no significant improvement was observed in the control group. The average dose of sulpiride at the end of the present study was less in the YKS group than in the control group. The MMSE results did not change either in the YKS group or in the control group. The Barthel Index did not significantly change either in the YKS group or in the control group. No serious adverse effects were noted.

CONCLUSIONS

Twelve weeks of the YKS treatment significantly improved BPSD with less antipsychotics in elderly patients with AD. The YKS treatment did not cause any cognitive decline or ADL decline and no serious adverse effects were noted. The present study suggests that YKS is beneficial for the treatment of BPSD and that it can possibly reduce the doses of antipsychotics required for the treatment of BPSD. Further studies with larger patient populations using a double-blind placebo-controlled design should be performed.

Authors+Show Affiliations

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kysushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. amonji@hf.rim.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19138715

Citation

Monji, Akira, et al. "Effect of Yokukansan On the Behavioral and Psychological Symptoms of Dementia in Elderly Patients With Alzheimer's Disease." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 33, no. 2, 2009, pp. 308-11.
Monji A, Takita M, Samejima T, et al. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(2):308-11.
Monji, A., Takita, M., Samejima, T., Takaishi, T., Hashimoto, K., Matsunaga, H., Oda, M., Sumida, Y., Mizoguchi, Y., Kato, T., Horikawa, H., & Kanba, S. (2009). Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33(2), 308-11. https://doi.org/10.1016/j.pnpbp.2008.12.008
Monji A, et al. Effect of Yokukansan On the Behavioral and Psychological Symptoms of Dementia in Elderly Patients With Alzheimer's Disease. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):308-11. PubMed PMID: 19138715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. AU - Monji,Akira, AU - Takita,Masashi, AU - Samejima,Takaaki, AU - Takaishi,Toshihiro, AU - Hashimoto,Kazuhito, AU - Matsunaga,Hiroyuki, AU - Oda,Mariko, AU - Sumida,Yasuhisa, AU - Mizoguchi,Yoshito, AU - Kato,Takahiro, AU - Horikawa,Hideki, AU - Kanba,Shigenobu, Y1 - 2008/12/24/ PY - 2008/10/16/received PY - 2008/12/15/revised PY - 2008/12/15/accepted PY - 2009/1/14/entrez PY - 2009/1/14/pubmed PY - 2009/6/3/medline SP - 308 EP - 11 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 33 IS - 2 N2 - OBJECTIVE: The aim of this study was to investigate the effects of yokukansan (YKS) on the behavioral and psychological symptoms of dementia (BPSD) in elderly patients with Alzheimer's disease (AD). METHODS: Fifteen patients with AD (mean age: 80.2+/-4.0 years) participated in the study. The Mini-Mental State Examination (MMSE) was used for the assessment of cognitive function. BPSD were evaluated using the Neuropsychiatric Inventory (NPI). The Barthel Index was used for the assessment for the activities of daily living (ADL). The treatment with YKS along with sulpiride, a dopamine D(2) selective antipsychotic, was performed for 12 weeks. RESULTS: Fourteen patients completed the trial. After the 12 weeks of treatment with YKS, significant improvement of the mean NPI score was observed while no significant improvement was observed in the control group. The average dose of sulpiride at the end of the present study was less in the YKS group than in the control group. The MMSE results did not change either in the YKS group or in the control group. The Barthel Index did not significantly change either in the YKS group or in the control group. No serious adverse effects were noted. CONCLUSIONS: Twelve weeks of the YKS treatment significantly improved BPSD with less antipsychotics in elderly patients with AD. The YKS treatment did not cause any cognitive decline or ADL decline and no serious adverse effects were noted. The present study suggests that YKS is beneficial for the treatment of BPSD and that it can possibly reduce the doses of antipsychotics required for the treatment of BPSD. Further studies with larger patient populations using a double-blind placebo-controlled design should be performed. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/19138715/Effect_of_yokukansan_on_the_behavioral_and_psychological_symptoms_of_dementia_in_elderly_patients_with_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00376-X DB - PRIME DP - Unbound Medicine ER -