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Platelet-rich plasma - A promising cell carrier for micro-invasive articular cartilage repair.
Med Hypotheses 2009; 72(4):455-7MH

Abstract

Due to the limited regenerative capacity of cartilage tissues, articular cartilage defect caused by various lesions remains a problem to be resolved. Tissue engineering provided a valuable alternative to current therapeutic approaches, which is expected to greatly reduce the need of joint replacement. Scaffold, acting as cell carrier, plays an important role in maintaining cells in defect sites, thus facilitates the chondrogenesis. However, an open operation is often needed to implant the cell/scaffold composite, to find a less invasive way to delivering the complex into the defect site would be desirable. Different from synthetic and other nature derived scaffold, platelet-rich plasma (PRP) is a fraction of plasma which contains multiple growth factors and could be clotted when mixed with thrombin. Therefore, we hypothesized that PRP could be used as an autologous cell carrier to inject and fix chondrocytes into the defect site of articular cartilage. With the assistance of arthroscope, the defect could be precisely located, and injectable PRP-Cell composite would make the operation micro-invasive and simple.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, Qin Du Hospital, School of Stomatology, Fourth Military Medical University, Changle West Road 145#, Xi'an 710032, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19138823

Citation

Wu, Wei, et al. "Platelet-rich Plasma - a Promising Cell Carrier for Micro-invasive Articular Cartilage Repair." Medical Hypotheses, vol. 72, no. 4, 2009, pp. 455-7.
Wu W, Zhang J, Dong Q, et al. Platelet-rich plasma - A promising cell carrier for micro-invasive articular cartilage repair. Med Hypotheses. 2009;72(4):455-7.
Wu, W., Zhang, J., Dong, Q., Liu, Y., Mao, T., & Chen, F. (2009). Platelet-rich plasma - A promising cell carrier for micro-invasive articular cartilage repair. Medical Hypotheses, 72(4), pp. 455-7. doi:10.1016/j.mehy.2008.11.032.
Wu W, et al. Platelet-rich Plasma - a Promising Cell Carrier for Micro-invasive Articular Cartilage Repair. Med Hypotheses. 2009;72(4):455-7. PubMed PMID: 19138823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet-rich plasma - A promising cell carrier for micro-invasive articular cartilage repair. AU - Wu,Wei, AU - Zhang,Junrui, AU - Dong,Qinshan, AU - Liu,Yanpu, AU - Mao,Tianqiu, AU - Chen,Fulin, Y1 - 2009/01/12/ PY - 2008/10/21/received PY - 2008/11/06/accepted PY - 2009/1/14/entrez PY - 2009/1/14/pubmed PY - 2009/5/5/medline SP - 455 EP - 7 JF - Medical hypotheses JO - Med. Hypotheses VL - 72 IS - 4 N2 - Due to the limited regenerative capacity of cartilage tissues, articular cartilage defect caused by various lesions remains a problem to be resolved. Tissue engineering provided a valuable alternative to current therapeutic approaches, which is expected to greatly reduce the need of joint replacement. Scaffold, acting as cell carrier, plays an important role in maintaining cells in defect sites, thus facilitates the chondrogenesis. However, an open operation is often needed to implant the cell/scaffold composite, to find a less invasive way to delivering the complex into the defect site would be desirable. Different from synthetic and other nature derived scaffold, platelet-rich plasma (PRP) is a fraction of plasma which contains multiple growth factors and could be clotted when mixed with thrombin. Therefore, we hypothesized that PRP could be used as an autologous cell carrier to inject and fix chondrocytes into the defect site of articular cartilage. With the assistance of arthroscope, the defect could be precisely located, and injectable PRP-Cell composite would make the operation micro-invasive and simple. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/19138823/abstract/Platelet_rich_plasma___A_promising_cell_carrier_for_micro_invasive_articular_cartilage_repair_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(08)00592-6 DB - PRIME DP - Unbound Medicine ER -