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The vagus nerve as a modulator of intestinal inflammation.
Neurogastroenterol Motil. 2009 Jan; 21(1):6-17.NM

Abstract

The cholinergic nervous system attenuates the production of pro-inflammatory cytokines and inhibits inflammatory processes. Hence, in animal models of intestinal inflammation, such as postoperative ileus and dextran sulfate sodium-induced colitis, vagus nerve stimulation ameliorates disease activity. On the other hand, in infectious models of microbial peritonitis, vagus nerve activation seemingly acts counteractive; it impairs bacterial clearance and increases mortality. It is originally indicated that the key mediator of the cholinergic anti-inflammatory pathway, acetylcholine (ACh), inhibits cytokine release directly via the alpha7 nicotinic ACh receptor (nAChR) expressed on macrophages. However, more recent data also point towards the vagus nerve as an indirect modulator of innate inflammatory processes, exerting its anti-inflammatory effects via postganglionic modulation of immune cells in primary immune organs. This review discusses advances in the possible mechanisms by which the vagus nerve can mediate the immune response, and the role of nAChR activation and signalling on macrophages and other immune cells.

Authors+Show Affiliations

Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19140954

Citation

Van Der Zanden, E P., et al. "The Vagus Nerve as a Modulator of Intestinal Inflammation." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 21, no. 1, 2009, pp. 6-17.
Van Der Zanden EP, Boeckxstaens GE, de Jonge WJ. The vagus nerve as a modulator of intestinal inflammation. Neurogastroenterol Motil. 2009;21(1):6-17.
Van Der Zanden, E. P., Boeckxstaens, G. E., & de Jonge, W. J. (2009). The vagus nerve as a modulator of intestinal inflammation. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 21(1), 6-17. https://doi.org/10.1111/j.1365-2982.2008.01252.x
Van Der Zanden EP, Boeckxstaens GE, de Jonge WJ. The Vagus Nerve as a Modulator of Intestinal Inflammation. Neurogastroenterol Motil. 2009;21(1):6-17. PubMed PMID: 19140954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The vagus nerve as a modulator of intestinal inflammation. AU - Van Der Zanden,E P, AU - Boeckxstaens,G E, AU - de Jonge,W J, PY - 2009/1/15/entrez PY - 2009/1/15/pubmed PY - 2009/3/6/medline SP - 6 EP - 17 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 21 IS - 1 N2 - The cholinergic nervous system attenuates the production of pro-inflammatory cytokines and inhibits inflammatory processes. Hence, in animal models of intestinal inflammation, such as postoperative ileus and dextran sulfate sodium-induced colitis, vagus nerve stimulation ameliorates disease activity. On the other hand, in infectious models of microbial peritonitis, vagus nerve activation seemingly acts counteractive; it impairs bacterial clearance and increases mortality. It is originally indicated that the key mediator of the cholinergic anti-inflammatory pathway, acetylcholine (ACh), inhibits cytokine release directly via the alpha7 nicotinic ACh receptor (nAChR) expressed on macrophages. However, more recent data also point towards the vagus nerve as an indirect modulator of innate inflammatory processes, exerting its anti-inflammatory effects via postganglionic modulation of immune cells in primary immune organs. This review discusses advances in the possible mechanisms by which the vagus nerve can mediate the immune response, and the role of nAChR activation and signalling on macrophages and other immune cells. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/19140954/The_vagus_nerve_as_a_modulator_of_intestinal_inflammation_ L2 - https://doi.org/10.1111/j.1365-2982.2008.01252.x DB - PRIME DP - Unbound Medicine ER -