Tags

Type your tag names separated by a space and hit enter

Effects of thalidomide on DMBA-induced oral carcinogenesis in hamster with respect to angiogenesis.
J Oral Pathol Med. 2009 May; 38(5):455-62.JO

Abstract

BACKGROUND

Thalidomide has been shown to have anti-angiogenic effects in pre-clinical models as well as a significant antitumor effect in hematologic tumors. However, the effects of thalidomide on oral pre-malignant lesions and oral carcinogenesis remain unexplored. The authors aimed to investigate the chemopreventive effect of thalidomide on 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters with respect to angiogenesis.

METHODS

Seventy male Syrian golden hamsters were randomly divided into five groups, with two of 20 and three of 10. DMBA solution (0.5% in acetone) was applied topically to the left cheek pouch of male Syrian golden hamsters in group A and B, while animals in group C were painted with acetone, three times a week for 6 weeks. For the next 18 weeks, animals in group B and D received thalidomide daily (40 mg/kg body weight/day) by gavage, animals in group A and C received same volume of saline. Animals in group E received no treatment and served as blank control. At the end of the experiment, animals were killed and tissue samples were collected for examinations.

RESULTS

Thalidomide significantly decreased the squamous cell carcinoma (SCC) incidence from 57.9 to 11.8%; angiogenesis was inhibited in dysplasia and SCC. The gene expression of vascular endothelium growth factor and tumor necrosis factor (TNF)-alpha was downregulated.

CONCLUSIONS

Thalidomide has inhibitory effect against the malignant transformation of oral pre-cancerous lesion and angiogenesis during oral carcinogenesis. Such inhibition is related to its modulation of TNF-alpha.

Authors+Show Affiliations

Department of General Dentistry, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. julieyy@163.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19141066

Citation

Yang, Y, et al. "Effects of Thalidomide On DMBA-induced Oral Carcinogenesis in Hamster With Respect to Angiogenesis." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 38, no. 5, 2009, pp. 455-62.
Yang Y, Ge JP, Zhou ZT. Effects of thalidomide on DMBA-induced oral carcinogenesis in hamster with respect to angiogenesis. J Oral Pathol Med. 2009;38(5):455-62.
Yang, Y., Ge, J. P., & Zhou, Z. T. (2009). Effects of thalidomide on DMBA-induced oral carcinogenesis in hamster with respect to angiogenesis. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 38(5), 455-62. https://doi.org/10.1111/j.1600-0714.2008.00737.x
Yang Y, Ge JP, Zhou ZT. Effects of Thalidomide On DMBA-induced Oral Carcinogenesis in Hamster With Respect to Angiogenesis. J Oral Pathol Med. 2009;38(5):455-62. PubMed PMID: 19141066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of thalidomide on DMBA-induced oral carcinogenesis in hamster with respect to angiogenesis. AU - Yang,Y, AU - Ge,J-P, AU - Zhou,Z-T, Y1 - 2009/01/06/ PY - 2009/1/15/entrez PY - 2009/1/15/pubmed PY - 2009/9/25/medline SP - 455 EP - 62 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 38 IS - 5 N2 - BACKGROUND: Thalidomide has been shown to have anti-angiogenic effects in pre-clinical models as well as a significant antitumor effect in hematologic tumors. However, the effects of thalidomide on oral pre-malignant lesions and oral carcinogenesis remain unexplored. The authors aimed to investigate the chemopreventive effect of thalidomide on 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters with respect to angiogenesis. METHODS: Seventy male Syrian golden hamsters were randomly divided into five groups, with two of 20 and three of 10. DMBA solution (0.5% in acetone) was applied topically to the left cheek pouch of male Syrian golden hamsters in group A and B, while animals in group C were painted with acetone, three times a week for 6 weeks. For the next 18 weeks, animals in group B and D received thalidomide daily (40 mg/kg body weight/day) by gavage, animals in group A and C received same volume of saline. Animals in group E received no treatment and served as blank control. At the end of the experiment, animals were killed and tissue samples were collected for examinations. RESULTS: Thalidomide significantly decreased the squamous cell carcinoma (SCC) incidence from 57.9 to 11.8%; angiogenesis was inhibited in dysplasia and SCC. The gene expression of vascular endothelium growth factor and tumor necrosis factor (TNF)-alpha was downregulated. CONCLUSIONS: Thalidomide has inhibitory effect against the malignant transformation of oral pre-cancerous lesion and angiogenesis during oral carcinogenesis. Such inhibition is related to its modulation of TNF-alpha. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/19141066/Effects_of_thalidomide_on_DMBA_induced_oral_carcinogenesis_in_hamster_with_respect_to_angiogenesis_ L2 - https://doi.org/10.1111/j.1600-0714.2008.00737.x DB - PRIME DP - Unbound Medicine ER -