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Ocular hypertension and diabetes mellitus in the Beijing Eye Study.
J Glaucoma 2009; 18(1):21-5JG

Abstract

PURPOSE

To determine prevalence and associated factors of ocular hypertension in the adult Chinese population.

METHODS

The Beijing Eye Study, a population-based prevalence study, included 4439 subjects out of 5324 subjects with an age of 40+ years invited to participate (response rate 83.4%). From the 4439 individuals, 4224 (95.2%) subjects fulfilled the inclusion criteria of the present study, that is, available readable optic disc photographs, a nonglaucomatous appearance of the optic disc, and a normal visual field in the case of an intraocular pressure higher than 21 mm Hg. The participants underwent an interview, a detailed ophthalmic examination, blood pressure measurements, and examination of blood samples. Ocular hypertension was defined as an intraocular pressure higher than 21 mm Hg with a normal appearance of the optic nerve head and no defects in frequency doubling perimetry.

RESULTS

Ocular hypertension was detected in 299 (3.6%) eyes (prevalence rate: 3.63%+/-0.21%) of 160 (3.8%) subjects (prevalence rate: 3.79%+/-0.29%). In multiple regression analysis, ocular hypertension was significantly associated with serum levels of cholesterol [P=0.006; odds ratio (OR): 1.34; 95% confidence interval (CI): 1.09-1.64], presence of diabetes mellitus (P=0.03; OR: 1.45; 95% CI: 1.04-2.07) and arterial hypertension (P<0.001; OR: 3.18; 95% CI: 1.86-5.43). Ocular hypertension was not significantly associated with age, sex, urban or rural region, refractive error, anterior chamber depth, optic disc area, and area of beta zone of parapapillary atrophy.

CONCLUSIONS

Ocular hypertension has a frequency of about 3.6% in the adult Chinese population with an age of 40+ years. Associated factors are diabetes mellitus, arterial hypertension, and elevated serum cholesterol levels. Diabetes mellitus, arterial hypertension, and elevated serum cholesterol concentrations should be checked in ocular hypertensive subjects.

Authors+Show Affiliations

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. xuliang5918@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19142130

Citation

Xu, Liang, et al. "Ocular Hypertension and Diabetes Mellitus in the Beijing Eye Study." Journal of Glaucoma, vol. 18, no. 1, 2009, pp. 21-5.
Xu L, Wang YX, Jonas JB, et al. Ocular hypertension and diabetes mellitus in the Beijing Eye Study. J Glaucoma. 2009;18(1):21-5.
Xu, L., Wang, Y. X., Jonas, J. B., Wang, Y. S., & Wang, S. (2009). Ocular hypertension and diabetes mellitus in the Beijing Eye Study. Journal of Glaucoma, 18(1), pp. 21-5. doi:10.1097/IJG.0b013e31816b301e.
Xu L, et al. Ocular Hypertension and Diabetes Mellitus in the Beijing Eye Study. J Glaucoma. 2009;18(1):21-5. PubMed PMID: 19142130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular hypertension and diabetes mellitus in the Beijing Eye Study. AU - Xu,Liang, AU - Wang,Ya Xing, AU - Jonas,Jost B, AU - Wang,Yun Shong, AU - Wang,Shuang, PY - 2009/1/15/entrez PY - 2009/1/15/pubmed PY - 2009/4/4/medline SP - 21 EP - 5 JF - Journal of glaucoma JO - J. Glaucoma VL - 18 IS - 1 N2 - PURPOSE: To determine prevalence and associated factors of ocular hypertension in the adult Chinese population. METHODS: The Beijing Eye Study, a population-based prevalence study, included 4439 subjects out of 5324 subjects with an age of 40+ years invited to participate (response rate 83.4%). From the 4439 individuals, 4224 (95.2%) subjects fulfilled the inclusion criteria of the present study, that is, available readable optic disc photographs, a nonglaucomatous appearance of the optic disc, and a normal visual field in the case of an intraocular pressure higher than 21 mm Hg. The participants underwent an interview, a detailed ophthalmic examination, blood pressure measurements, and examination of blood samples. Ocular hypertension was defined as an intraocular pressure higher than 21 mm Hg with a normal appearance of the optic nerve head and no defects in frequency doubling perimetry. RESULTS: Ocular hypertension was detected in 299 (3.6%) eyes (prevalence rate: 3.63%+/-0.21%) of 160 (3.8%) subjects (prevalence rate: 3.79%+/-0.29%). In multiple regression analysis, ocular hypertension was significantly associated with serum levels of cholesterol [P=0.006; odds ratio (OR): 1.34; 95% confidence interval (CI): 1.09-1.64], presence of diabetes mellitus (P=0.03; OR: 1.45; 95% CI: 1.04-2.07) and arterial hypertension (P<0.001; OR: 3.18; 95% CI: 1.86-5.43). Ocular hypertension was not significantly associated with age, sex, urban or rural region, refractive error, anterior chamber depth, optic disc area, and area of beta zone of parapapillary atrophy. CONCLUSIONS: Ocular hypertension has a frequency of about 3.6% in the adult Chinese population with an age of 40+ years. Associated factors are diabetes mellitus, arterial hypertension, and elevated serum cholesterol levels. Diabetes mellitus, arterial hypertension, and elevated serum cholesterol concentrations should be checked in ocular hypertensive subjects. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/19142130/Ocular_hypertension_and_diabetes_mellitus_in_the_Beijing_Eye_Study_ L2 - http://Insights.ovid.com/pubmed?pmid=19142130 DB - PRIME DP - Unbound Medicine ER -