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Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study.
Int J Cancer 2009; 124(10):2384-90IJ

Abstract

Acrylamide, a probable human carcinogen, is formed during the cooking of many commonly consumed foods. Data are scant on whether dietary acrylamide represents an important cancer risk in humans. We studied the association between acrylamide and prostate cancer risk using 2 measures of acrylamide exposure: intake from a food frequency questionnaire (FFQ) and acrylamide adducts to hemoglobin. We also studied the correlation between these 2 exposure measures. We used data from the population-based case-control study Cancer of the Prostate in Sweden (CAPS). Dietary data was available for 1,499 cases and 1,118 controls. Hemoglobin adducts of acrylamide were measured in blood samples from a subset of 170 cases and 161 controls. We calculated odds ratios (ORs) for the risk of prostate cancer in high versus low quantiles of acrylamide exposure using logistic regression. The correlation between FFQ acrylamide intake and acrylamide adducts in non-smokers was 0.25 (95% confidence interval: 0.14-0.35), adjusted for age, region, energy intake, and laboratory batch. Among controls the correlation was 0.35 (95% CI: 0.21-0.48); among cases it was 0.15 (95% CI: 0.00-0.30). The OR of prostate cancer for the highest versus lowest quartile of acrylamide adducts was 0.93 (95% CI: 0.47-1.85, p-value for trend = 0.98). For FFQ acrylamide, the OR of prostate cancer for the highest versus lowest quintile was 0.97 (95% CI: 0.75-1.27, p trend = 0.67). No significant associations were found between acrylamide exposure and risk of prostate cancer by stage, grade, or PSA level. Acrylamide adducts to hemoglobin and FFQ-measured acrylamide intake were moderately correlated. Neither measure of acrylamide exposure-hemoglobin adducts or FFQ-was associated with risk of prostate cancer.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. kwilson@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19142870

Citation

Wilson, Kathryn M., et al. "Acrylamide Exposure Measured By Food Frequency Questionnaire and Hemoglobin Adduct Levels and Prostate Cancer Risk in the Cancer of the Prostate in Sweden Study." International Journal of Cancer, vol. 124, no. 10, 2009, pp. 2384-90.
Wilson KM, Bälter K, Adami HO, et al. Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study. Int J Cancer. 2009;124(10):2384-90.
Wilson, K. M., Bälter, K., Adami, H. O., Grönberg, H., Vikström, A. C., Paulsson, B., ... Mucci, L. A. (2009). Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study. International Journal of Cancer, 124(10), pp. 2384-90. doi:10.1002/ijc.24175.
Wilson KM, et al. Acrylamide Exposure Measured By Food Frequency Questionnaire and Hemoglobin Adduct Levels and Prostate Cancer Risk in the Cancer of the Prostate in Sweden Study. Int J Cancer. 2009 May 15;124(10):2384-90. PubMed PMID: 19142870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study. AU - Wilson,Kathryn M, AU - Bälter,Katarina, AU - Adami,Hans-Olov, AU - Grönberg,Henrik, AU - Vikström,Anna C, AU - Paulsson,Birgit, AU - Törnqvist,Margareta, AU - Mucci,Lorelei A, PY - 2009/1/15/entrez PY - 2009/1/15/pubmed PY - 2009/4/15/medline SP - 2384 EP - 90 JF - International journal of cancer JO - Int. J. Cancer VL - 124 IS - 10 N2 - Acrylamide, a probable human carcinogen, is formed during the cooking of many commonly consumed foods. Data are scant on whether dietary acrylamide represents an important cancer risk in humans. We studied the association between acrylamide and prostate cancer risk using 2 measures of acrylamide exposure: intake from a food frequency questionnaire (FFQ) and acrylamide adducts to hemoglobin. We also studied the correlation between these 2 exposure measures. We used data from the population-based case-control study Cancer of the Prostate in Sweden (CAPS). Dietary data was available for 1,499 cases and 1,118 controls. Hemoglobin adducts of acrylamide were measured in blood samples from a subset of 170 cases and 161 controls. We calculated odds ratios (ORs) for the risk of prostate cancer in high versus low quantiles of acrylamide exposure using logistic regression. The correlation between FFQ acrylamide intake and acrylamide adducts in non-smokers was 0.25 (95% confidence interval: 0.14-0.35), adjusted for age, region, energy intake, and laboratory batch. Among controls the correlation was 0.35 (95% CI: 0.21-0.48); among cases it was 0.15 (95% CI: 0.00-0.30). The OR of prostate cancer for the highest versus lowest quartile of acrylamide adducts was 0.93 (95% CI: 0.47-1.85, p-value for trend = 0.98). For FFQ acrylamide, the OR of prostate cancer for the highest versus lowest quintile was 0.97 (95% CI: 0.75-1.27, p trend = 0.67). No significant associations were found between acrylamide exposure and risk of prostate cancer by stage, grade, or PSA level. Acrylamide adducts to hemoglobin and FFQ-measured acrylamide intake were moderately correlated. Neither measure of acrylamide exposure-hemoglobin adducts or FFQ-was associated with risk of prostate cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19142870/Acrylamide_exposure_measured_by_food_frequency_questionnaire_and_hemoglobin_adduct_levels_and_prostate_cancer_risk_in_the_Cancer_of_the_Prostate_in_Sweden_Study_ L2 - https://doi.org/10.1002/ijc.24175 DB - PRIME DP - Unbound Medicine ER -