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Effect-site concentration of remifentanil for laryngeal mask airway insertion during target-controlled infusion of propofol.
Anaesthesia. 2009 Feb; 64(2):136-40.A

Abstract

The purpose of this study was to determine the effect-site concentration of remifentanil that would provide optimal conditions for successful laryngeal mask airway insertion during a target-controlled infusion (TCI) of propofol at 3.5 microg.ml(-1) without the use of neuromuscular blockade. Five minutes after propofol infusion, remifentanil was infused at a dose determined by a modified Dixon's up-and-down method. Five minutes after remifentanil infusion, the laryngeal mask was inserted. The effect-site concentration of remifentanil for successful laryngeal mask insertion in 50% of adults (EC(50)) was 3.04 (SD 0.49) ng.ml(-1) during a TCI of 3.5 microg.ml(-1) propofol without neuromuscular blockade. From the probit analysis, the EC(50) and EC(95) of remifentanil were 2.84 ng.ml(-1) (95% CI 2.09-3.57 ng.ml(-1)) and 3.79 ng.ml(-1) (95% CI 3.26-9.25 ng.ml(-1)), respectively.

Authors+Show Affiliations

Department of Anaesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19143689

Citation

Kim, M K., et al. "Effect-site Concentration of Remifentanil for Laryngeal Mask Airway Insertion During Target-controlled Infusion of Propofol." Anaesthesia, vol. 64, no. 2, 2009, pp. 136-40.
Kim MK, Lee JW, Jang DJ, et al. Effect-site concentration of remifentanil for laryngeal mask airway insertion during target-controlled infusion of propofol. Anaesthesia. 2009;64(2):136-40.
Kim, M. K., Lee, J. W., Jang, D. J., Shin, O. Y., & Nam, S. B. (2009). Effect-site concentration of remifentanil for laryngeal mask airway insertion during target-controlled infusion of propofol. Anaesthesia, 64(2), 136-40. https://doi.org/10.1111/j.1365-2044.2008.05707.x
Kim MK, et al. Effect-site Concentration of Remifentanil for Laryngeal Mask Airway Insertion During Target-controlled Infusion of Propofol. Anaesthesia. 2009;64(2):136-40. PubMed PMID: 19143689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect-site concentration of remifentanil for laryngeal mask airway insertion during target-controlled infusion of propofol. AU - Kim,M K, AU - Lee,J W, AU - Jang,D J, AU - Shin,O Y, AU - Nam,S B, PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/2/7/medline SP - 136 EP - 40 JF - Anaesthesia JO - Anaesthesia VL - 64 IS - 2 N2 - The purpose of this study was to determine the effect-site concentration of remifentanil that would provide optimal conditions for successful laryngeal mask airway insertion during a target-controlled infusion (TCI) of propofol at 3.5 microg.ml(-1) without the use of neuromuscular blockade. Five minutes after propofol infusion, remifentanil was infused at a dose determined by a modified Dixon's up-and-down method. Five minutes after remifentanil infusion, the laryngeal mask was inserted. The effect-site concentration of remifentanil for successful laryngeal mask insertion in 50% of adults (EC(50)) was 3.04 (SD 0.49) ng.ml(-1) during a TCI of 3.5 microg.ml(-1) propofol without neuromuscular blockade. From the probit analysis, the EC(50) and EC(95) of remifentanil were 2.84 ng.ml(-1) (95% CI 2.09-3.57 ng.ml(-1)) and 3.79 ng.ml(-1) (95% CI 3.26-9.25 ng.ml(-1)), respectively. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/19143689/Effect_site_concentration_of_remifentanil_for_laryngeal_mask_airway_insertion_during_target_controlled_infusion_of_propofol_ L2 - https://doi.org/10.1111/j.1365-2044.2008.05707.x DB - PRIME DP - Unbound Medicine ER -