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Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4).
J Sex Med. 2009 Mar; 6(3):809-19.JS

Abstract

INTRODUCTION

The Erection Hardness Score (EHS), a validated single-item patient-reported outcome (PRO), may provide a simple method to capture erectile dysfunction (ED) symptoms and to monitor treatment outcome.

AIM

To map the relationship between the EHS, which was used as the anchor, and other validated PROs: International Index of Erectile Function (IIEF), Quality of Erection Questionnaire (QEQ), Sexual Experience Questionnaire (SEX-Q), and Self-Esteem and Relationship questionnaire (SEAR). Methods. Data were from a trial of flexible-dose sildenafil (50 or 100 mg) in 209 men with ED.

MAIN OUTCOME MEASURES

A mixed-effects repeated-measures model with EHS as a categorical explanatory variable and each of the other PROs, as a separate dependent variable, was applied to analyze the longitudinal data from randomization to the end of the 10-week, double-blind, placebo-controlled phase and the 6-week open-label phase. EHS data, which were generated at each sexual encounter (event), were averaged per patient over the same recall period that preceded administration of the other PRO questionnaires.

RESULTS

Scores on all domains of the IIEF and SEX-Q, as well as the SEAR total score and SEAR Sexual Relationship domain, discriminated on all EHS categories. The QEQ total score discriminated on all EHS categories except EHS 1 and EHS 2. Although the model did not impose any functional relationship between PRO score and EHS, an approximately linear relationship existed between the EHS and all other PROs, which was especially pronounced for those PROs that were more directly related to erectile quality or function.

CONCLUSIONS

The relationship between discrete EHS categories and PRO scores demonstrates the close correspondence of erectile hardness with erectile function (IIEF), erection quality (QEQ), overall sexual experience (SEX-Q), and ED-related psychosocial factors (SEAR) in men with ED.

Authors+Show Affiliations

Pfizer Inc,-Global Research & Development, New London, CT 06320, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19143915

Citation

Cappelleri, Joseph C., et al. "Scoring Correspondence in Outcomes Related to Erectile Dysfunction Treatment On a 4-point Scale (SCORE-4)." The Journal of Sexual Medicine, vol. 6, no. 3, 2009, pp. 809-19.
Cappelleri JC, Bushmakin AG, Symonds T, et al. Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4). J Sex Med. 2009;6(3):809-19.
Cappelleri, J. C., Bushmakin, A. G., Symonds, T., & Schnetzler, G. (2009). Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4). The Journal of Sexual Medicine, 6(3), 809-19. https://doi.org/10.1111/j.1743-6109.2008.01155.x
Cappelleri JC, et al. Scoring Correspondence in Outcomes Related to Erectile Dysfunction Treatment On a 4-point Scale (SCORE-4). J Sex Med. 2009;6(3):809-19. PubMed PMID: 19143915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4). AU - Cappelleri,Joseph C, AU - Bushmakin,Andrew G, AU - Symonds,Tara, AU - Schnetzler,Gabriel, Y1 - 2009/01/07/ PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/8/19/medline SP - 809 EP - 19 JF - The journal of sexual medicine JO - J Sex Med VL - 6 IS - 3 N2 - INTRODUCTION: The Erection Hardness Score (EHS), a validated single-item patient-reported outcome (PRO), may provide a simple method to capture erectile dysfunction (ED) symptoms and to monitor treatment outcome. AIM: To map the relationship between the EHS, which was used as the anchor, and other validated PROs: International Index of Erectile Function (IIEF), Quality of Erection Questionnaire (QEQ), Sexual Experience Questionnaire (SEX-Q), and Self-Esteem and Relationship questionnaire (SEAR). Methods. Data were from a trial of flexible-dose sildenafil (50 or 100 mg) in 209 men with ED. MAIN OUTCOME MEASURES: A mixed-effects repeated-measures model with EHS as a categorical explanatory variable and each of the other PROs, as a separate dependent variable, was applied to analyze the longitudinal data from randomization to the end of the 10-week, double-blind, placebo-controlled phase and the 6-week open-label phase. EHS data, which were generated at each sexual encounter (event), were averaged per patient over the same recall period that preceded administration of the other PRO questionnaires. RESULTS: Scores on all domains of the IIEF and SEX-Q, as well as the SEAR total score and SEAR Sexual Relationship domain, discriminated on all EHS categories. The QEQ total score discriminated on all EHS categories except EHS 1 and EHS 2. Although the model did not impose any functional relationship between PRO score and EHS, an approximately linear relationship existed between the EHS and all other PROs, which was especially pronounced for those PROs that were more directly related to erectile quality or function. CONCLUSIONS: The relationship between discrete EHS categories and PRO scores demonstrates the close correspondence of erectile hardness with erectile function (IIEF), erection quality (QEQ), overall sexual experience (SEX-Q), and ED-related psychosocial factors (SEAR) in men with ED. SN - 1743-6109 UR - https://www.unboundmedicine.com/medline/citation/19143915/Scoring_correspondence_in_outcomes_related_to_erectile_dysfunction_treatment_on_a_4_point_scale__SCORE_4__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)32426-7 DB - PRIME DP - Unbound Medicine ER -