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Impact of oxidative stress on lung diseases.
Respirology. 2009 Jan; 14(1):27-38.R

Abstract

Reactive oxygen species (ROS) are products of normal cellular metabolism and are known to act as second messengers. Under physiological conditions, ROS participate in maintenance of cellular 'redox homeostasis' in order to protect cells against oxidative stress through various redox-regulatory mechanisms. Overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate by cytokines or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress. Oxidative stress is a deleterious process that leads to lung damage and consequently to various disease states. Knowledge of the mechanisms of ROS regulation could lead to the pharmacological manipulation of antioxidants in lung inflammation and injury.

Authors+Show Affiliations

Department of Internal Medicine, Chungnam National University Medical School, Daejeon, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19144046

Citation

Park, Hee Sun, et al. "Impact of Oxidative Stress On Lung Diseases." Respirology (Carlton, Vic.), vol. 14, no. 1, 2009, pp. 27-38.
Park HS, Kim SR, Lee YC. Impact of oxidative stress on lung diseases. Respirology. 2009;14(1):27-38.
Park, H. S., Kim, S. R., & Lee, Y. C. (2009). Impact of oxidative stress on lung diseases. Respirology (Carlton, Vic.), 14(1), 27-38. https://doi.org/10.1111/j.1440-1843.2008.01447.x
Park HS, Kim SR, Lee YC. Impact of Oxidative Stress On Lung Diseases. Respirology. 2009;14(1):27-38. PubMed PMID: 19144046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of oxidative stress on lung diseases. AU - Park,Hee Sun, AU - Kim,So Ri, AU - Lee,Yong Chul, PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/5/9/medline SP - 27 EP - 38 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 14 IS - 1 N2 - Reactive oxygen species (ROS) are products of normal cellular metabolism and are known to act as second messengers. Under physiological conditions, ROS participate in maintenance of cellular 'redox homeostasis' in order to protect cells against oxidative stress through various redox-regulatory mechanisms. Overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate by cytokines or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress. Oxidative stress is a deleterious process that leads to lung damage and consequently to various disease states. Knowledge of the mechanisms of ROS regulation could lead to the pharmacological manipulation of antioxidants in lung inflammation and injury. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/19144046/Impact_of_oxidative_stress_on_lung_diseases_ L2 - https://doi.org/10.1111/j.1440-1843.2008.01447.x DB - PRIME DP - Unbound Medicine ER -