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Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Cancer Causes Control 2009; 20(5):785-94CC

Abstract

OBJECTIVE

To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS

Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes.

RESULTS

Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption.

CONCLUSION

These results suggest no association of alcohol consumption with the risk of pancreatic cancer.

Authors+Show Affiliations

Division of Clinical Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. s.rohrmann@dkfz.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19145468

Citation

Rohrmann, Sabine, et al. "Ethanol Intake and the Risk of Pancreatic Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Cancer Causes & Control : CCC, vol. 20, no. 5, 2009, pp. 785-94.
Rohrmann S, Linseisen J, Vrieling A, et al. Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control. 2009;20(5):785-94.
Rohrmann, S., Linseisen, J., Vrieling, A., Boffetta, P., Stolzenberg-Solomon, R. Z., Lowenfels, A. B., ... Bueno-de-Mesquita, H. B. (2009). Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes & Control : CCC, 20(5), pp. 785-94. doi:10.1007/s10552-008-9293-8.
Rohrmann S, et al. Ethanol Intake and the Risk of Pancreatic Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Cancer Causes Control. 2009;20(5):785-94. PubMed PMID: 19145468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Vrieling,Alina, AU - Boffetta,Paolo, AU - Stolzenberg-Solomon,Rachael Z, AU - Lowenfels,Albert B, AU - Jensen,Majken K, AU - Overvad,Kim, AU - Olsen,Anja, AU - Tjonneland,Anne, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Francoise, AU - Fagherazzi,G, AU - Misirli,Gesthimani, AU - Lagiou,Pagona, AU - Trichopoulou,Antonia, AU - Kaaks,Rudolf, AU - Bergmann,Manuela M, AU - Boeing,Heiner, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Allen,Naomi, AU - Roddam,Andrew, AU - Palli,Domenico, AU - Pala,Valeria, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - Peeters,Petra H M, AU - Hjartåker,Anette, AU - Lund,Eiliv, AU - Redondo Cornejo,Ma Luisa, AU - Agudo,Antonio, AU - Arriola,Larraitz, AU - Sánchez,Maria-José, AU - Tormo,María-José, AU - Barricarte Gurrea,Aurelio, AU - Lindkvist,Björn, AU - Manjer,Jonas, AU - Johansson,Ingegerd, AU - Ye,Weimin, AU - Slimani,Nadia, AU - Duell,Eric J, AU - Jenab,Mazda, AU - Michaud,Dominique S, AU - Mouw,Traci, AU - Riboli,Elio, AU - Bueno-de-Mesquita,H Bas, Y1 - 2009/01/16/ PY - 2008/11/10/received PY - 2008/12/27/accepted PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/9/16/medline SP - 785 EP - 94 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 20 IS - 5 N2 - OBJECTIVE: To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. RESULTS: Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. CONCLUSION: These results suggest no association of alcohol consumption with the risk of pancreatic cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19145468/Ethanol_intake_and_the_risk_of_pancreatic_cancer_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - https://doi.org/10.1007/s10552-008-9293-8 DB - PRIME DP - Unbound Medicine ER -