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[Functional role of the endocannabinoid system in emotional homeostasis].
Rev Neurol 2009 Jan 1-15; 48(1):20-6RN

Abstract

INTRODUCTION AND DEVELOPMENT

Cannabis and derivatives induce complex effects on anxiety in humans and experimental animals. At low doses, cannabinoid agonists seem to exert anxiolytic actions, while at high doses anxiety and panic estates are often reported. Diverse animal models confirm this particular biphasic profile; however, the underlying neurobiological mechanisms have not been completely elucidated. The anxiogenic-like behavioral phenotype observed following both pharmacological and genetic blockade of cannabinoid CB1 receptors, together with the abundant expression of cannabinoid receptors within brain areas particularly involved in emotional control, such as amygdala, hippocampus and cortex, are among the numerous evidences that account for the participation of the endocannabinoid system in the regulation of anxiety states. Moreover, blockade of endogenous cannabinoid ligands deactivation has been reported to induce anxiolytic-like responses.

CONCLUSIONS

Taken together, present data reinforce the involvement of the endocannabinoid system in the control of emotional homeostasis and further suggest the pharmacological manipulation of the endocannabinoid system as a potential therapeutic tool in the management of anxiety-related disorders.

Authors+Show Affiliations

Departamento de Fisiología, Universidad Complutense, Madrid, España.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

spa

PubMed ID

19145562

Citation

Marco, E M., and M P. Viveros. "[Functional Role of the Endocannabinoid System in Emotional Homeostasis]." Revista De Neurologia, vol. 48, no. 1, 2009, pp. 20-6.
Marco EM, Viveros MP. [Functional role of the endocannabinoid system in emotional homeostasis]. Rev Neurol. 2009;48(1):20-6.
Marco, E. M., & Viveros, M. P. (2009). [Functional role of the endocannabinoid system in emotional homeostasis]. Revista De Neurologia, 48(1), pp. 20-6.
Marco EM, Viveros MP. [Functional Role of the Endocannabinoid System in Emotional Homeostasis]. Rev Neurol. 2009;48(1):20-6. PubMed PMID: 19145562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Functional role of the endocannabinoid system in emotional homeostasis]. AU - Marco,E M, AU - Viveros,M P, PY - 2009/1/16/entrez PY - 2009/1/16/pubmed PY - 2009/3/18/medline SP - 20 EP - 6 JF - Revista de neurologia JO - Rev Neurol VL - 48 IS - 1 N2 - INTRODUCTION AND DEVELOPMENT: Cannabis and derivatives induce complex effects on anxiety in humans and experimental animals. At low doses, cannabinoid agonists seem to exert anxiolytic actions, while at high doses anxiety and panic estates are often reported. Diverse animal models confirm this particular biphasic profile; however, the underlying neurobiological mechanisms have not been completely elucidated. The anxiogenic-like behavioral phenotype observed following both pharmacological and genetic blockade of cannabinoid CB1 receptors, together with the abundant expression of cannabinoid receptors within brain areas particularly involved in emotional control, such as amygdala, hippocampus and cortex, are among the numerous evidences that account for the participation of the endocannabinoid system in the regulation of anxiety states. Moreover, blockade of endogenous cannabinoid ligands deactivation has been reported to induce anxiolytic-like responses. CONCLUSIONS: Taken together, present data reinforce the involvement of the endocannabinoid system in the control of emotional homeostasis and further suggest the pharmacological manipulation of the endocannabinoid system as a potential therapeutic tool in the management of anxiety-related disorders. SN - 1576-6578 UR - https://www.unboundmedicine.com/medline/citation/19145562/[Functional_role_of_the_endocannabinoid_system_in_emotional_homeostasis]_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2008218&Revista=RevNeurol DB - PRIME DP - Unbound Medicine ER -