Tags

Type your tag names separated by a space and hit enter

Natural Arctium lappa fruit extract improves the clinical signs of aging skin.
J Cosmet Dermatol. 2008 Dec; 7(4):281-9.JC

Abstract

BACKGROUND

Subclinical, chronic tissue inflammation involving the generation of cytokines (e.g., interleukin-6 and tumor necrosis factor-alpha) might contribute to the cutaneous aging process.

AIMS

This study aims to screen for an active ingredient with anti-inflammatory (i.e., reduction of interleukin-6 and tumor necrosis factor-alpha) and matrix-stimulating efficacy which improves the clinical signs of skin aging in vivo.

PATIENTS/METHODS

In vitro studies with pure Arctiin were performed investigating the inhibition of cytokine induction and stimulation of collagen neo-synthesis. In vivo home-in-use studies using an Arctium lappa fruit extract-containing formulation were carried out to determine procollagen and hyaluronan synthesis, hyaluronan synthase-2 gene expression, and reduction of wrinkle volume after treatment.

RESULTS

In vitro studies on human dermal fibroblasts and monocyte-derived dendritic cells supplemented with pure Arctiin showed relative to untreated control cells a stimulation of collagen synthesis and a decrease in interleukin-6 and tumor necrosis factor-alpha concentration, respectively. In addition, topical in vivo application of an A. lappa fruit extract-containing formulation for 12 weeks significantly stimulated procollagen synthesis and increased hyaluronan synthase-2 expression as well as hyaluronan levels compared to vehicle-treated control areas. Similarly, after a 4-week treatment with an A. lappa fruit extract-containing formulation, wrinkle volume in the crow's feet area was significantly reduced as compared to treatment with the vehicle.

CONCLUSIONS

Our data show that topical treatment with a natural A. lappa fruit extract significantly improves the metabolism of the dermal extracellular matrix and leads to a visible wrinkle reduction in vivo. In conclusion, A. lappa fruit extract represents a targeted means to regenerate dermal structures and, thus, offers an effective treatment option for mature skin.

Authors+Show Affiliations

Research & Development, Beiersdorf AG, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19146605

Citation

Knott, Anja, et al. "Natural Arctium Lappa Fruit Extract Improves the Clinical Signs of Aging Skin." Journal of Cosmetic Dermatology, vol. 7, no. 4, 2008, pp. 281-9.
Knott A, Reuschlein K, Mielke H, et al. Natural Arctium lappa fruit extract improves the clinical signs of aging skin. J Cosmet Dermatol. 2008;7(4):281-9.
Knott, A., Reuschlein, K., Mielke, H., Wensorra, U., Mummert, C., Koop, U., Kausch, M., Kolbe, L., Peters, N., Stäb, F., Wenck, H., & Gallinat, S. (2008). Natural Arctium lappa fruit extract improves the clinical signs of aging skin. Journal of Cosmetic Dermatology, 7(4), 281-9. https://doi.org/10.1111/j.1473-2165.2008.00407.x
Knott A, et al. Natural Arctium Lappa Fruit Extract Improves the Clinical Signs of Aging Skin. J Cosmet Dermatol. 2008;7(4):281-9. PubMed PMID: 19146605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural Arctium lappa fruit extract improves the clinical signs of aging skin. AU - Knott,Anja, AU - Reuschlein,Katja, AU - Mielke,Heiko, AU - Wensorra,Ursula, AU - Mummert,Christopher, AU - Koop,Urte, AU - Kausch,Martina, AU - Kolbe,Ludger, AU - Peters,Nils, AU - Stäb,Franz, AU - Wenck,Horst, AU - Gallinat,Stefan, PY - 2009/1/17/entrez PY - 2009/1/17/pubmed PY - 2009/4/7/medline SP - 281 EP - 9 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 7 IS - 4 N2 - BACKGROUND: Subclinical, chronic tissue inflammation involving the generation of cytokines (e.g., interleukin-6 and tumor necrosis factor-alpha) might contribute to the cutaneous aging process. AIMS: This study aims to screen for an active ingredient with anti-inflammatory (i.e., reduction of interleukin-6 and tumor necrosis factor-alpha) and matrix-stimulating efficacy which improves the clinical signs of skin aging in vivo. PATIENTS/METHODS: In vitro studies with pure Arctiin were performed investigating the inhibition of cytokine induction and stimulation of collagen neo-synthesis. In vivo home-in-use studies using an Arctium lappa fruit extract-containing formulation were carried out to determine procollagen and hyaluronan synthesis, hyaluronan synthase-2 gene expression, and reduction of wrinkle volume after treatment. RESULTS: In vitro studies on human dermal fibroblasts and monocyte-derived dendritic cells supplemented with pure Arctiin showed relative to untreated control cells a stimulation of collagen synthesis and a decrease in interleukin-6 and tumor necrosis factor-alpha concentration, respectively. In addition, topical in vivo application of an A. lappa fruit extract-containing formulation for 12 weeks significantly stimulated procollagen synthesis and increased hyaluronan synthase-2 expression as well as hyaluronan levels compared to vehicle-treated control areas. Similarly, after a 4-week treatment with an A. lappa fruit extract-containing formulation, wrinkle volume in the crow's feet area was significantly reduced as compared to treatment with the vehicle. CONCLUSIONS: Our data show that topical treatment with a natural A. lappa fruit extract significantly improves the metabolism of the dermal extracellular matrix and leads to a visible wrinkle reduction in vivo. In conclusion, A. lappa fruit extract represents a targeted means to regenerate dermal structures and, thus, offers an effective treatment option for mature skin. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/19146605/Natural_Arctium_lappa_fruit_extract_improves_the_clinical_signs_of_aging_skin_ L2 - https://doi.org/10.1111/j.1473-2165.2008.00407.x DB - PRIME DP - Unbound Medicine ER -