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The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice.
Transpl Immunol 2009; 20(4):253-60TI

Abstract

CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells, produced in the thymus or periphery as a functionally mature T cell subpopulation, play pivotal roles in maintenance of self-tolerance and negative regulation of immune responses. Aspirin (ASA) is widely used to reduce pain, the risk of cardiovascular diseases and allo-graft rejection. However, the effect of ASA on CD4(+)CD25(+)Foxp3(+) Treg cells has yet to be determined. The frequency, phenotype and immunosuppressive function of CD4(+)CD25(+)Foxp3(+) Treg cells were detected in BALB/c mice treated with low or high doses of ASA for 4 weeks. ASA significantly decreased the percentage and number of CD4(+) T cells in the periphery, while ASA remarkably increased the percentage of CD4(+)CD25(+)Foxp3(+) Treg cells in CD4(+)T cells. The total cell numbers of thymocytes were significantly decreased in ASA-treated mice, but the number of CD4(+) CD25(+)Fxop3(+) cells and its ratio in CD4(+)CD8(-) thymocytes were markedly enhanced in the thymi of ASA-treated mice. The phenotype of CD4(+)CD25(+) Treg cells, including the expressions of CD44, CD45RB, CD62L, CD69, GITR and CTLA-4, did not show detectable changes in ASA-treated mice. CD4(+)CD25(+) Treg cells in ASA-treated mice exhibited unimpaired immunosuppressive function on CD4(+)CD25(-) T effector cells. ASA significantly enhanced the frequency of functional CD4(+)CD25(+)Foxp3(+) Treg cells in mice in a therapeutic dose range. The different effects of ASA on CD4(+)CD25(+)Foxp3(+) Treg cells and CD4(+)CD25(-) T cells may potentially make hosts susceptible to tolerance induction which would be beneficial for tolerance induction in patients with autoimmune diseases or allo-grafts. This study may have potential impacts in the clinical application of ASA.

Authors+Show Affiliations

Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19146957

Citation

Javeed, Aqeel, et al. "The Significantly Enhanced Frequency of Functional CD4+CD25+Foxp3+ T Regulatory Cells in Therapeutic Dose Aspirin-treated Mice." Transplant Immunology, vol. 20, no. 4, 2009, pp. 253-60.
Javeed A, Zhang B, Qu Y, et al. The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. Transpl Immunol. 2009;20(4):253-60.
Javeed, A., Zhang, B., Qu, Y., Zhang, A., Sun, C., Zhang, L., ... Zhao, Y. (2009). The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. Transplant Immunology, 20(4), pp. 253-60. doi:10.1016/j.trim.2008.12.001.
Javeed A, et al. The Significantly Enhanced Frequency of Functional CD4+CD25+Foxp3+ T Regulatory Cells in Therapeutic Dose Aspirin-treated Mice. Transpl Immunol. 2009;20(4):253-60. PubMed PMID: 19146957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. AU - Javeed,Aqeel, AU - Zhang,Baojun, AU - Qu,Yanyan, AU - Zhang,Aijun, AU - Sun,Chenming, AU - Zhang,Lianjun, AU - Liu,Jun, AU - Zeng,Chun, AU - Zhao,Yong, Y1 - 2009/01/13/ PY - 2008/09/11/received PY - 2008/11/24/revised PY - 2008/12/04/accepted PY - 2009/1/17/entrez PY - 2009/1/17/pubmed PY - 2009/5/15/medline SP - 253 EP - 60 JF - Transplant immunology JO - Transpl. Immunol. VL - 20 IS - 4 N2 - CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells, produced in the thymus or periphery as a functionally mature T cell subpopulation, play pivotal roles in maintenance of self-tolerance and negative regulation of immune responses. Aspirin (ASA) is widely used to reduce pain, the risk of cardiovascular diseases and allo-graft rejection. However, the effect of ASA on CD4(+)CD25(+)Foxp3(+) Treg cells has yet to be determined. The frequency, phenotype and immunosuppressive function of CD4(+)CD25(+)Foxp3(+) Treg cells were detected in BALB/c mice treated with low or high doses of ASA for 4 weeks. ASA significantly decreased the percentage and number of CD4(+) T cells in the periphery, while ASA remarkably increased the percentage of CD4(+)CD25(+)Foxp3(+) Treg cells in CD4(+)T cells. The total cell numbers of thymocytes were significantly decreased in ASA-treated mice, but the number of CD4(+) CD25(+)Fxop3(+) cells and its ratio in CD4(+)CD8(-) thymocytes were markedly enhanced in the thymi of ASA-treated mice. The phenotype of CD4(+)CD25(+) Treg cells, including the expressions of CD44, CD45RB, CD62L, CD69, GITR and CTLA-4, did not show detectable changes in ASA-treated mice. CD4(+)CD25(+) Treg cells in ASA-treated mice exhibited unimpaired immunosuppressive function on CD4(+)CD25(-) T effector cells. ASA significantly enhanced the frequency of functional CD4(+)CD25(+)Foxp3(+) Treg cells in mice in a therapeutic dose range. The different effects of ASA on CD4(+)CD25(+)Foxp3(+) Treg cells and CD4(+)CD25(-) T cells may potentially make hosts susceptible to tolerance induction which would be beneficial for tolerance induction in patients with autoimmune diseases or allo-grafts. This study may have potential impacts in the clinical application of ASA. SN - 0966-3274 UR - https://www.unboundmedicine.com/medline/citation/19146957/The_significantly_enhanced_frequency_of_functional_CD4+CD25+Foxp3+_T_regulatory_cells_in_therapeutic_dose_aspirin_treated_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966-3274(08)00127-5 DB - PRIME DP - Unbound Medicine ER -