Tags

Type your tag names separated by a space and hit enter

The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry.
J Am Coll Cardiol. 2009 Jan 20; 53(3):264-71.JACC

Abstract

OBJECTIVES

This study sought to determine the relationship between pre-transplant ventricular assist device (VAD) support and mortality after heart transplantation.

BACKGROUND

Increasingly, VADs are being used to bridge patients to heart transplantation. The effect of these devices on post-transplant mortality is unclear.

METHODS

Patients 18 years or older who underwent first-time, single-organ heart transplantation in the U.S. between 1995 and 2004 were included in the analyses. This study compared 1,433 patients bridged with intracorporeal and 448 patients bridged with extracorporeal VADs with 9,455 United Network for Organ Sharing status 1 patients not bridged with a VAD with respect to post-transplant mortality. Because the proportional hazards assumption was not met, hazard ratios (HRs) for different time periods were estimated.

RESULTS

Intracorporeal VADs were associated with an HR of 1.20 (95% confidence interval [CI]: 1.02 to 1.43; p = 0.03) for mortality in the first 6 months after transplant and an HR of 1.99 (95% CI: 1.44 to 2.75; p < 0.0001) beyond 5 years. Between 6 months and 5 years, the HRs were not significantly different from 1. Extracorporeal VADs were associated with an HR of 1.91 (95% CI: 1.53 to 2.37; p < 0.0001) for mortality in the first 6 months and an HR of 2.93 (95% CI: 1.19 to 7.25; p = 0.02) beyond 5 years. The HRs were not significantly different from 1 between 6 months and 5 years, except for an HR of 0.23 (95% CI: 0.06 to 0.91; p = 0.04) between 24 and 36 months.

CONCLUSIONS

Extracorporeal VADs are associated with higher mortality within 6 months and again beyond 5 years after transplantation. Intracorporeal VADs are associated with a small increase in mortality in the first 6 months and a clinically significant increase in mortality beyond 5 years. These data do not provide evidence supporting VAD implantation in stable United Network for Organ Sharing status I patients awaiting heart transplantation.

Authors+Show Affiliations

Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19147043

Citation

Patlolla, Vishnu, et al. "The Effect of Ventricular Assist Devices On Post-transplant Mortality an Analysis of the United Network for Organ Sharing Thoracic Registry." Journal of the American College of Cardiology, vol. 53, no. 3, 2009, pp. 264-71.
Patlolla V, Patten RD, Denofrio D, et al. The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry. J Am Coll Cardiol. 2009;53(3):264-71.
Patlolla, V., Patten, R. D., Denofrio, D., Konstam, M. A., & Krishnamani, R. (2009). The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry. Journal of the American College of Cardiology, 53(3), 264-71. https://doi.org/10.1016/j.jacc.2008.08.070
Patlolla V, et al. The Effect of Ventricular Assist Devices On Post-transplant Mortality an Analysis of the United Network for Organ Sharing Thoracic Registry. J Am Coll Cardiol. 2009 Jan 20;53(3):264-71. PubMed PMID: 19147043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry. AU - Patlolla,Vishnu, AU - Patten,Richard D, AU - Denofrio,David, AU - Konstam,Marvin A, AU - Krishnamani,Rajan, PY - 2008/04/29/received PY - 2008/07/14/revised PY - 2008/08/18/accepted PY - 2009/1/17/entrez PY - 2009/1/17/pubmed PY - 2009/2/5/medline SP - 264 EP - 71 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 53 IS - 3 N2 - OBJECTIVES: This study sought to determine the relationship between pre-transplant ventricular assist device (VAD) support and mortality after heart transplantation. BACKGROUND: Increasingly, VADs are being used to bridge patients to heart transplantation. The effect of these devices on post-transplant mortality is unclear. METHODS: Patients 18 years or older who underwent first-time, single-organ heart transplantation in the U.S. between 1995 and 2004 were included in the analyses. This study compared 1,433 patients bridged with intracorporeal and 448 patients bridged with extracorporeal VADs with 9,455 United Network for Organ Sharing status 1 patients not bridged with a VAD with respect to post-transplant mortality. Because the proportional hazards assumption was not met, hazard ratios (HRs) for different time periods were estimated. RESULTS: Intracorporeal VADs were associated with an HR of 1.20 (95% confidence interval [CI]: 1.02 to 1.43; p = 0.03) for mortality in the first 6 months after transplant and an HR of 1.99 (95% CI: 1.44 to 2.75; p < 0.0001) beyond 5 years. Between 6 months and 5 years, the HRs were not significantly different from 1. Extracorporeal VADs were associated with an HR of 1.91 (95% CI: 1.53 to 2.37; p < 0.0001) for mortality in the first 6 months and an HR of 2.93 (95% CI: 1.19 to 7.25; p = 0.02) beyond 5 years. The HRs were not significantly different from 1 between 6 months and 5 years, except for an HR of 0.23 (95% CI: 0.06 to 0.91; p = 0.04) between 24 and 36 months. CONCLUSIONS: Extracorporeal VADs are associated with higher mortality within 6 months and again beyond 5 years after transplantation. Intracorporeal VADs are associated with a small increase in mortality in the first 6 months and a clinically significant increase in mortality beyond 5 years. These data do not provide evidence supporting VAD implantation in stable United Network for Organ Sharing status I patients awaiting heart transplantation. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/19147043/The_effect_of_ventricular_assist_devices_on_post_transplant_mortality_an_analysis_of_the_United_network_for_organ_sharing_thoracic_registry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(08)03458-X DB - PRIME DP - Unbound Medicine ER -