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Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials.
Ann Med 2009; 41(4):301-10AM

Abstract

AIM

To systematically review trials concerning the effects of omega-3 fatty acids on sudden cardiac death (SCD), cardiac death, and all-cause mortality in coronary heart disease (CHD) patients.

METHODS

PubMed, Embase, and the Cochrane database (1966-2007) were searched. We identified randomized controlled trials that compared dietary or supplementary intake of omega-3 fatty acids with control diet or placebo in CHD patients. Eligible studies had at least 6 months of follow-up data, and cited SCD as an end-point. Two reviewers independently assessed methodological quality. Meta-analysis of relative risk was carried out using the random effect model.

RESULTS

Eight trials were identified, comprising 20,997 patients. In patients with prior myocardial infarction (MI), omega-3 fatty acids reduced relative risk (RR) of SCD (RR = 0.43; 95% CI: 0.20-0.91). In patients with angina, omega-3 fatty acids increased RR of SCD (RR = 1.39; 95% CI: 1.01-1.92). Overall, RR for cardiac death and all-cause mortality were 0.71 (95% CI: 0.50-1.00) and 0.77 (95% CI: 0.58-1.01), respectively.

CONCLUSIONS

Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with MI, but may have adverse effects in angina patients.

Authors+Show Affiliations

Department of Cardiology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19148838

Citation

Zhao, Yun-Tao, et al. "Prevention of Sudden Cardiac Death With Omega-3 Fatty Acids in Patients With Coronary Heart Disease: a Meta-analysis of Randomized Controlled Trials." Annals of Medicine, vol. 41, no. 4, 2009, pp. 301-10.
Zhao YT, Chen Q, Sun YX, et al. Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Ann Med. 2009;41(4):301-10.
Zhao, Y. T., Chen, Q., Sun, Y. X., Li, X. B., Zhang, P., Xu, Y., & Guo, J. H. (2009). Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Annals of Medicine, 41(4), pp. 301-10. doi:10.1080/07853890802698834.
Zhao YT, et al. Prevention of Sudden Cardiac Death With Omega-3 Fatty Acids in Patients With Coronary Heart Disease: a Meta-analysis of Randomized Controlled Trials. Ann Med. 2009;41(4):301-10. PubMed PMID: 19148838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials. AU - Zhao,Yun-Tao, AU - Chen,Qiang, AU - Sun,Ya-Xun, AU - Li,Xue-Bin, AU - Zhang,Ping, AU - Xu,Yuan, AU - Guo,Ji-Hong, PY - 2009/1/17/entrez PY - 2009/1/17/pubmed PY - 2009/7/8/medline SP - 301 EP - 10 JF - Annals of medicine JO - Ann. Med. VL - 41 IS - 4 N2 - AIM: To systematically review trials concerning the effects of omega-3 fatty acids on sudden cardiac death (SCD), cardiac death, and all-cause mortality in coronary heart disease (CHD) patients. METHODS: PubMed, Embase, and the Cochrane database (1966-2007) were searched. We identified randomized controlled trials that compared dietary or supplementary intake of omega-3 fatty acids with control diet or placebo in CHD patients. Eligible studies had at least 6 months of follow-up data, and cited SCD as an end-point. Two reviewers independently assessed methodological quality. Meta-analysis of relative risk was carried out using the random effect model. RESULTS: Eight trials were identified, comprising 20,997 patients. In patients with prior myocardial infarction (MI), omega-3 fatty acids reduced relative risk (RR) of SCD (RR = 0.43; 95% CI: 0.20-0.91). In patients with angina, omega-3 fatty acids increased RR of SCD (RR = 1.39; 95% CI: 1.01-1.92). Overall, RR for cardiac death and all-cause mortality were 0.71 (95% CI: 0.50-1.00) and 0.77 (95% CI: 0.58-1.01), respectively. CONCLUSIONS: Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with MI, but may have adverse effects in angina patients. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/19148838/Prevention_of_sudden_cardiac_death_with_omega_3_fatty_acids_in_patients_with_coronary_heart_disease:_a_meta_analysis_of_randomized_controlled_trials_ L2 - http://www.tandfonline.com/doi/full/10.1080/07853890802698834 DB - PRIME DP - Unbound Medicine ER -