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Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity.
Geriatr Gerontol Int. 2008 Dec; 8(4):243-50.GG

Abstract

AIM

The immune response to influenza vaccine is attenuated in elderly persons, though they are at greatest risk for morbidity and mortality by influenza virus infection. Experimental studies demonstrate that co-administration of l-cystine and l-theanine enhanced antigen-specific production of immunoglobulin in aged mice infected with influenza virus. We thus investigated the effect of l-cystine and l-theanine on antibody induction by influenza vaccines in elderly persons.

METHODS

Residents in a nursing home were randomly allocated to l-cystine and l-theanine (n = 32) or placebo (n = 33). The test substances were administered p.o. for 14 days before immunization. Serum influenza virus antibody titers were measured before and 4 weeks after vaccination.

RESULTS

Vaccination significantly elevated hemagglutination inhibition (HI) titers for all the three strains of influenza viruses (A/New Caledonia [H1N1], A/New York [H3N2] and B/Shanghai) in both groups. HI titers after vaccination were not significantly different between the two groups for either strain. Also, the seroconversion rate was not significantly different between the two groups in the aggregate. A stratified analysis showed that the rate of seroconversion was significantly greater in the l-cystine and l-theanine group compared with the placebo group for influenza virus A (H1N1) among subjects with low serum total protein (63% vs 10%, P < 0.05) or low hemoglobin (71% vs 9%, P < 0.05).

CONCLUSION

Co-administration of l-cystine and l-theanine before vaccination may enhance the immune response to influenza vaccine in elderly subjects with low serum total protein or hemoglobin.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Miyagawa K
Department of Internal Medicine, Nagoya Kosein Hospital, Nagoya, Japan. miyagawa@sc.starcat.ne.jp
Hayashi Y
No affiliation info available
Kurihara S
No affiliation info available
Maeda A
No affiliation info available

MeSH

Administration, OralAgedAged, 80 and overAnemiaCystineDietary SupplementsDrug Therapy, CombinationFemaleFrail ElderlyGlutamatesHomes for the AgedHumansHypoproteinemiaInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza VaccinesMaleNursing Homes

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19149835

Citation

Miyagawa, Koichi, et al. "Co-administration of L-cystine and L-theanine Enhances Efficacy of Influenza Vaccination in Elderly Persons: Nutritional Status-dependent Immunogenicity." Geriatrics & Gerontology International, vol. 8, no. 4, 2008, pp. 243-50.
Miyagawa K, Hayashi Y, Kurihara S, et al. Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. Geriatr Gerontol Int. 2008;8(4):243-50.
Miyagawa, K., Hayashi, Y., Kurihara, S., & Maeda, A. (2008). Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. Geriatrics & Gerontology International, 8(4), 243-50. https://doi.org/10.1111/j.1447-0594.2008.00483.x
Miyagawa K, et al. Co-administration of L-cystine and L-theanine Enhances Efficacy of Influenza Vaccination in Elderly Persons: Nutritional Status-dependent Immunogenicity. Geriatr Gerontol Int. 2008;8(4):243-50. PubMed PMID: 19149835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. AU - Miyagawa,Koichi, AU - Hayashi,Yoshimitsu, AU - Kurihara,Shigekazu, AU - Maeda,Akiko, PY - 2009/1/20/entrez PY - 2009/1/20/pubmed PY - 2009/4/29/medline SP - 243 EP - 50 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 8 IS - 4 N2 - AIM: The immune response to influenza vaccine is attenuated in elderly persons, though they are at greatest risk for morbidity and mortality by influenza virus infection. Experimental studies demonstrate that co-administration of l-cystine and l-theanine enhanced antigen-specific production of immunoglobulin in aged mice infected with influenza virus. We thus investigated the effect of l-cystine and l-theanine on antibody induction by influenza vaccines in elderly persons. METHODS: Residents in a nursing home were randomly allocated to l-cystine and l-theanine (n = 32) or placebo (n = 33). The test substances were administered p.o. for 14 days before immunization. Serum influenza virus antibody titers were measured before and 4 weeks after vaccination. RESULTS: Vaccination significantly elevated hemagglutination inhibition (HI) titers for all the three strains of influenza viruses (A/New Caledonia [H1N1], A/New York [H3N2] and B/Shanghai) in both groups. HI titers after vaccination were not significantly different between the two groups for either strain. Also, the seroconversion rate was not significantly different between the two groups in the aggregate. A stratified analysis showed that the rate of seroconversion was significantly greater in the l-cystine and l-theanine group compared with the placebo group for influenza virus A (H1N1) among subjects with low serum total protein (63% vs 10%, P < 0.05) or low hemoglobin (71% vs 9%, P < 0.05). CONCLUSION: Co-administration of l-cystine and l-theanine before vaccination may enhance the immune response to influenza vaccine in elderly subjects with low serum total protein or hemoglobin. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/19149835/Co_administration_of_l_cystine_and_l_theanine_enhances_efficacy_of_influenza_vaccination_in_elderly_persons:_nutritional_status_dependent_immunogenicity_ DB - PRIME DP - Unbound Medicine ER -