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Effects of extended cocaine conditioning in the reinstatement of place preference.
Physiol Behav. 2009 Mar 23; 96(4-5):620-30.PB

Abstract

Rats allowed extended access to cocaine self-administration develop a number of symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the conditioned place preference (CPP), the number of conditioning training sessions was increased in order to augment exposure to contextual cues associated with the effects of a drug. Mice were conditioned with a steady dose of 6 or 25 mg/kg of cocaine for 4, 8, 12, 16, 20 or 40 days. Weekly sessions of extinction followed the establishment of preference, after which a priming dose of cocaine was administered to reinstate the extinguished preference. The magnitude of the place preference effect was equal in all groups, independently of the number of conditioning sessions. The persistence of the place preference was not related with the number of sessions. Higher responsiveness to reinstatement of the extinguished preference occurred only with an intermediate number of conditioning sessions. In this way, the relation between the number of training sessions and vulnerability to relapse appeared to follow an inverted U-shaped function. Our results suggest that increasing the number of conditioning sessions from 12 to up to 16, without increasing the amount of drug administered, can be of great use in the study of vulnerability to relapse.

Authors+Show Affiliations

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Universitat de Valencia, Avda. Blasco Ibáñez 21, Valencia 46010, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19150452

Citation

Rodríguez-Arias, Marta, et al. "Effects of Extended Cocaine Conditioning in the Reinstatement of Place Preference." Physiology & Behavior, vol. 96, no. 4-5, 2009, pp. 620-30.
Rodríguez-Arias M, Castillo A, Daza-Losada M, et al. Effects of extended cocaine conditioning in the reinstatement of place preference. Physiol Behav. 2009;96(4-5):620-30.
Rodríguez-Arias, M., Castillo, A., Daza-Losada, M., Aguilar, M. A., & Miñarro, J. (2009). Effects of extended cocaine conditioning in the reinstatement of place preference. Physiology & Behavior, 96(4-5), 620-30. https://doi.org/10.1016/j.physbeh.2008.12.011
Rodríguez-Arias M, et al. Effects of Extended Cocaine Conditioning in the Reinstatement of Place Preference. Physiol Behav. 2009 Mar 23;96(4-5):620-30. PubMed PMID: 19150452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of extended cocaine conditioning in the reinstatement of place preference. AU - Rodríguez-Arias,Marta, AU - Castillo,Ana, AU - Daza-Losada,Manuel, AU - Aguilar,María Asunción, AU - Miñarro,José, Y1 - 2008/12/31/ PY - 2008/07/14/received PY - 2008/12/16/revised PY - 2008/12/18/accepted PY - 2009/1/20/entrez PY - 2009/1/20/pubmed PY - 2009/5/27/medline SP - 620 EP - 30 JF - Physiology & behavior JO - Physiol Behav VL - 96 IS - 4-5 N2 - Rats allowed extended access to cocaine self-administration develop a number of symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the conditioned place preference (CPP), the number of conditioning training sessions was increased in order to augment exposure to contextual cues associated with the effects of a drug. Mice were conditioned with a steady dose of 6 or 25 mg/kg of cocaine for 4, 8, 12, 16, 20 or 40 days. Weekly sessions of extinction followed the establishment of preference, after which a priming dose of cocaine was administered to reinstate the extinguished preference. The magnitude of the place preference effect was equal in all groups, independently of the number of conditioning sessions. The persistence of the place preference was not related with the number of sessions. Higher responsiveness to reinstatement of the extinguished preference occurred only with an intermediate number of conditioning sessions. In this way, the relation between the number of training sessions and vulnerability to relapse appeared to follow an inverted U-shaped function. Our results suggest that increasing the number of conditioning sessions from 12 to up to 16, without increasing the amount of drug administered, can be of great use in the study of vulnerability to relapse. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/19150452/Effects_of_extended_cocaine_conditioning_in_the_reinstatement_of_place_preference_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(08)00395-8 DB - PRIME DP - Unbound Medicine ER -