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Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome.
Clin Nutr 2009; 28(1):94-9CN

Abstract

BACKGROUND & AIMS

Prader Willi syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, relative hypoinsulinemia and normal insulin sensitivity. PWS presents higher total (TG) and acylated ghrelin (AG) levels. The cause of this increase as well as the modulation of ghrelin secretion in fasting and feeding in relation to other metabolic parameters and glucose tolerance in PWS is largely unknown.

METHODS

We studied TG and AG at fasting in PWS children (14) and adults (18). We also studied TG and AG response to a mixed standardized light breakfast (SLB) in PWS adults without (AD-GT) and with glucose intolerance (AD-GI) at OGTT.

RESULTS

TG and AG were higher in children than in adults (p<0.05). AG was higher in adult males (p<0.001). Fasting AG and AG/TG ratio were lower in AD-GI than in AD-GT (p<0.05). TG, but not AG, decreased in AD-GT (p<0.006), whereas AG, but not TG, increased in AD-GI (p<0.03) post-SLB. Fasting TG and AG were negatively predicted by fasting insulin (p<0.05). Post-SLB AG was positively predicted by glucose during OGTT (p<0.04).

CONCLUSIONS

Fasting and post-meal AG levels are influenced by glucose tolerance in PWS, suggesting that AG derangement might have a role in the development of glucose intolerance.

Authors+Show Affiliations

Division of Paediatrics, Department of Medical Science, University of Piemonte Orientale, Novara, Italy. flavia.prodam@med.unipmn.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19150743

Citation

Prodam, Flavia, et al. "Influence of Age, Gender, and Glucose Tolerance On Fasting and Fed Acylated Ghrelin in Prader Willi Syndrome." Clinical Nutrition (Edinburgh, Scotland), vol. 28, no. 1, 2009, pp. 94-9.
Prodam F, Bellone S, Grugni G, et al. Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome. Clin Nutr. 2009;28(1):94-9.
Prodam, F., Bellone, S., Grugni, G., Crinò, A., Ragusa, L., Franzese, A., ... Bona, G. (2009). Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome. Clinical Nutrition (Edinburgh, Scotland), 28(1), pp. 94-9. doi:10.1016/j.clnu.2008.12.002.
Prodam F, et al. Influence of Age, Gender, and Glucose Tolerance On Fasting and Fed Acylated Ghrelin in Prader Willi Syndrome. Clin Nutr. 2009;28(1):94-9. PubMed PMID: 19150743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome. AU - Prodam,Flavia, AU - Bellone,Simonetta, AU - Grugni,Graziano, AU - Crinò,Antonino, AU - Ragusa,Letizia, AU - Franzese,Adriana, AU - Di Battista,Eliana, AU - Corrias,Andrea, AU - Walker,Gillian, AU - Rapa,Anna, AU - Aimaretti,Gianluca, AU - Bona,Gianni, Y1 - 2009/01/17/ PY - 2008/07/21/received PY - 2008/11/14/revised PY - 2008/12/07/accepted PY - 2009/1/20/entrez PY - 2009/1/20/pubmed PY - 2009/5/27/medline SP - 94 EP - 9 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 28 IS - 1 N2 - BACKGROUND & AIMS: Prader Willi syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, relative hypoinsulinemia and normal insulin sensitivity. PWS presents higher total (TG) and acylated ghrelin (AG) levels. The cause of this increase as well as the modulation of ghrelin secretion in fasting and feeding in relation to other metabolic parameters and glucose tolerance in PWS is largely unknown. METHODS: We studied TG and AG at fasting in PWS children (14) and adults (18). We also studied TG and AG response to a mixed standardized light breakfast (SLB) in PWS adults without (AD-GT) and with glucose intolerance (AD-GI) at OGTT. RESULTS: TG and AG were higher in children than in adults (p<0.05). AG was higher in adult males (p<0.001). Fasting AG and AG/TG ratio were lower in AD-GI than in AD-GT (p<0.05). TG, but not AG, decreased in AD-GT (p<0.006), whereas AG, but not TG, increased in AD-GI (p<0.03) post-SLB. Fasting TG and AG were negatively predicted by fasting insulin (p<0.05). Post-SLB AG was positively predicted by glucose during OGTT (p<0.04). CONCLUSIONS: Fasting and post-meal AG levels are influenced by glucose tolerance in PWS, suggesting that AG derangement might have a role in the development of glucose intolerance. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/19150743/Influence_of_age_gender_and_glucose_tolerance_on_fasting_and_fed_acylated_ghrelin_in_Prader_Willi_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(08)00224-0 DB - PRIME DP - Unbound Medicine ER -