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Alterations in regional brain volume and individual MRI-guided perfusion in normal control, stable mild cognitive impairment, and MCI-AD converter.
J Geriatr Psychiatry Neurol. 2009 Mar; 22(1):35-45.JG

Abstract

Regional differences in tissue volume and perfusion in brains of individuals with mild cognitive impairment (MCI) versus normal healthy age-matched controls (NC), and the differences between MCI-AD converters and stable MCI patients were investigated. MRI and SPECT scans were performed on 13 MCI (74+6 years) and 12 NC (75+4 years). Of the MCI patients, 10 were followed for up to three years and 4 subsequently converted to Alzheimer's disease (AD). Episodic memory function was assessed using tests of delayed recall for word lists and stories. The volume reductions and hypoperfusion were mainly confined to the medial temporal lobe (MTL) of MCI patients and associated with worse scores on memory tests. Perfusion in the corpus callosum and the gray matter of frontal, lateral temporal, parietal or occipital lobe was not significantly affected in MCI. The 4 MCI-AD converters had relatively low MTL structural volume and perfusion compared to their stable peers.

Authors+Show Affiliations

Tu and Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19150973

Citation

Wang, Huali, et al. "Alterations in Regional Brain Volume and Individual MRI-guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter." Journal of Geriatric Psychiatry and Neurology, vol. 22, no. 1, 2009, pp. 35-45.
Wang H, Golob E, Bert A, et al. Alterations in regional brain volume and individual MRI-guided perfusion in normal control, stable mild cognitive impairment, and MCI-AD converter. J Geriatr Psychiatry Neurol. 2009;22(1):35-45.
Wang, H., Golob, E., Bert, A., Nie, K., Chu, Y., Dick, M. B., Mandelkern, M., & Su, M. Y. (2009). Alterations in regional brain volume and individual MRI-guided perfusion in normal control, stable mild cognitive impairment, and MCI-AD converter. Journal of Geriatric Psychiatry and Neurology, 22(1), 35-45. https://doi.org/10.1177/0891988708328212
Wang H, et al. Alterations in Regional Brain Volume and Individual MRI-guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter. J Geriatr Psychiatry Neurol. 2009;22(1):35-45. PubMed PMID: 19150973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in regional brain volume and individual MRI-guided perfusion in normal control, stable mild cognitive impairment, and MCI-AD converter. AU - Wang,Huali, AU - Golob,Edward, AU - Bert,Alberto, AU - Nie,Ke, AU - Chu,Yong, AU - Dick,Malcolm B, AU - Mandelkern,Mark, AU - Su,Min-Ying, Y1 - 2009/01/15/ PY - 2009/1/20/entrez PY - 2009/1/20/pubmed PY - 2009/4/17/medline SP - 35 EP - 45 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 22 IS - 1 N2 - Regional differences in tissue volume and perfusion in brains of individuals with mild cognitive impairment (MCI) versus normal healthy age-matched controls (NC), and the differences between MCI-AD converters and stable MCI patients were investigated. MRI and SPECT scans were performed on 13 MCI (74+6 years) and 12 NC (75+4 years). Of the MCI patients, 10 were followed for up to three years and 4 subsequently converted to Alzheimer's disease (AD). Episodic memory function was assessed using tests of delayed recall for word lists and stories. The volume reductions and hypoperfusion were mainly confined to the medial temporal lobe (MTL) of MCI patients and associated with worse scores on memory tests. Perfusion in the corpus callosum and the gray matter of frontal, lateral temporal, parietal or occipital lobe was not significantly affected in MCI. The 4 MCI-AD converters had relatively low MTL structural volume and perfusion compared to their stable peers. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/19150973/Alterations_in_regional_brain_volume_and_individual_MRI_guided_perfusion_in_normal_control_stable_mild_cognitive_impairment_and_MCI_AD_converter_ L2 - https://journals.sagepub.com/doi/10.1177/0891988708328212?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -