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Effect of butachlor on antioxidant enzyme status and lipid peroxidation in fresh water African catfish, (Clarias gariepinus).
Int J Environ Res Public Health. 2008 Dec; 5(5):423-7.IJ

Abstract

The present study was undertaken to evaluate the influence of butachlor, a widely used herbicide, on antioxidant enzyme system and lipid peroxidation formation in African cat fish (Clarias gariepinus). Fish were exposed to sub-lethal concentrations of butachlor 1, 2, 2.5 ppm and sacrificed 24hrs after treatment. A significant increase in malondialdehyde formation was observed in the liver, kidney, gills and heart of the fish following exposure to different concentrations of butachlor. Superoxide dismutase and catalase activities increased in the liver and kidney but decreased in the gills and heart in a concentration-dependent pattern. Glutathione level and glutathione-Stransferase activities increased (P<0.05) in the liver but decreased in the kidneys, gills and heart when fishes were exposed to the three concentrations of butachlor. The results suggest that butachlor induced oxidative stress in the various tissues of the fish particularly in the kidney and as such the organ may be subjected to severe oxidative toxicity due to depressed glutathione detoxification system.

Authors+Show Affiliations

Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry College of Medicine, University of Ibadan, Nigeria. olatunde_farombi@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19151438

Citation

Farombi, E O., et al. "Effect of Butachlor On Antioxidant Enzyme Status and Lipid Peroxidation in Fresh Water African Catfish, (Clarias Gariepinus)." International Journal of Environmental Research and Public Health, vol. 5, no. 5, 2008, pp. 423-7.
Farombi EO, Ajimoko YR, Adelowo OA. Effect of butachlor on antioxidant enzyme status and lipid peroxidation in fresh water African catfish, (Clarias gariepinus). Int J Environ Res Public Health. 2008;5(5):423-7.
Farombi, E. O., Ajimoko, Y. R., & Adelowo, O. A. (2008). Effect of butachlor on antioxidant enzyme status and lipid peroxidation in fresh water African catfish, (Clarias gariepinus). International Journal of Environmental Research and Public Health, 5(5), 423-7.
Farombi EO, Ajimoko YR, Adelowo OA. Effect of Butachlor On Antioxidant Enzyme Status and Lipid Peroxidation in Fresh Water African Catfish, (Clarias Gariepinus). Int J Environ Res Public Health. 2008;5(5):423-7. PubMed PMID: 19151438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of butachlor on antioxidant enzyme status and lipid peroxidation in fresh water African catfish, (Clarias gariepinus). AU - Farombi,E O, AU - Ajimoko,Y R, AU - Adelowo,O A, PY - 2009/1/20/entrez PY - 2009/1/20/pubmed PY - 2009/4/4/medline SP - 423 EP - 7 JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 5 IS - 5 N2 - The present study was undertaken to evaluate the influence of butachlor, a widely used herbicide, on antioxidant enzyme system and lipid peroxidation formation in African cat fish (Clarias gariepinus). Fish were exposed to sub-lethal concentrations of butachlor 1, 2, 2.5 ppm and sacrificed 24hrs after treatment. A significant increase in malondialdehyde formation was observed in the liver, kidney, gills and heart of the fish following exposure to different concentrations of butachlor. Superoxide dismutase and catalase activities increased in the liver and kidney but decreased in the gills and heart in a concentration-dependent pattern. Glutathione level and glutathione-Stransferase activities increased (P<0.05) in the liver but decreased in the kidneys, gills and heart when fishes were exposed to the three concentrations of butachlor. The results suggest that butachlor induced oxidative stress in the various tissues of the fish particularly in the kidney and as such the organ may be subjected to severe oxidative toxicity due to depressed glutathione detoxification system. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/19151438/Effect_of_butachlor_on_antioxidant_enzyme_status_and_lipid_peroxidation_in_fresh_water_African_catfish__Clarias_gariepinus__ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19151438/ DB - PRIME DP - Unbound Medicine ER -