Tags

Type your tag names separated by a space and hit enter

Dietary modification of Parkinson's disease.
Eur J Clin Nutr. 1991 May; 45(5):263-6.EJ

Abstract

To investigate the efficacy of a low-protein diet suitable for long-term use, and to observe the effect in a double-blind manner of re-introducing large neutral amino acids or an inactive placebo amino acid, eight patients with 'on-off' phenomenon were given a low-protein diet suitable for long-term use, and then the diet was supplemented with large neutral amino acids (LNAA) or placebo in a double-blind crossover trial. Five patients had improved Parkinsonian disability on a low-protein diet compared to normal diet. On supplementing the diet with LNAA or placebo, three subjects' Parkinson's disease was significantly better on placebo and there was a trend towards improvement on placebo noticed subjectively by seven patients; however, there was no overall significant difference in disability measured by mobility diaries. Thus, we have been unable to show that the improvement on a low-protein diet is due to a reduction in LNAA, rather than a placebo effect, possibly due to the paucity of subjects; however, the patients' identification of the LNAA supplement suggests that it is a genuine effect.

Authors+Show Affiliations

Leicester Royal Infirmary, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1915197

Citation

Croxson, S, et al. "Dietary Modification of Parkinson's Disease." European Journal of Clinical Nutrition, vol. 45, no. 5, 1991, pp. 263-6.
Croxson S, Johnson B, Millac P, et al. Dietary modification of Parkinson's disease. Eur J Clin Nutr. 1991;45(5):263-6.
Croxson, S., Johnson, B., Millac, P., & Pye, I. (1991). Dietary modification of Parkinson's disease. European Journal of Clinical Nutrition, 45(5), 263-6.
Croxson S, et al. Dietary Modification of Parkinson's Disease. Eur J Clin Nutr. 1991;45(5):263-6. PubMed PMID: 1915197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary modification of Parkinson's disease. AU - Croxson,S, AU - Johnson,B, AU - Millac,P, AU - Pye,I, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 263 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 45 IS - 5 N2 - To investigate the efficacy of a low-protein diet suitable for long-term use, and to observe the effect in a double-blind manner of re-introducing large neutral amino acids or an inactive placebo amino acid, eight patients with 'on-off' phenomenon were given a low-protein diet suitable for long-term use, and then the diet was supplemented with large neutral amino acids (LNAA) or placebo in a double-blind crossover trial. Five patients had improved Parkinsonian disability on a low-protein diet compared to normal diet. On supplementing the diet with LNAA or placebo, three subjects' Parkinson's disease was significantly better on placebo and there was a trend towards improvement on placebo noticed subjectively by seven patients; however, there was no overall significant difference in disability measured by mobility diaries. Thus, we have been unable to show that the improvement on a low-protein diet is due to a reduction in LNAA, rather than a placebo effect, possibly due to the paucity of subjects; however, the patients' identification of the LNAA supplement suggests that it is a genuine effect. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/1915197/Dietary_modification_of_Parkinson's_disease_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -