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The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women.
Arch Gynecol Obstet. 2009 Sep; 280(3):381-7.AG

Abstract

OBJECTIVE

The relationship of homocyteine, B12 and folic acid with osteoporosis has already been studied in various populations. We compared the important factors in the metabolism of homocysteine, such as homocysteine, B12 and folic acid levels, of Turkish postmenopausal women, and their relationship with the femur and lumbar spine bone mineral density.

METHODS

This cross-sectional study was conducted at Gazi University, Department of Obstetrics and Gynecology. The study group consisted of 178 postmenopausal women. Serum homocysteine, folic acid and Vitamin B12 were measured. BMD was measured using DEXA at the right femoral neck and lumbar spine (L1-L4).

RESULTS

Upon evaluation of both the femur and lumbar spine, it was determined that osteoporosis could be associated with a homocysteine level above the median and with a B12 value under the lowest quintile value.

CONCLUSION

Plasma Hcy and vitamin B12, but not folate levels, were associated with osteoporosis. Future interventional studies are needed to determine methods to reduce Hcy levels with dietary supplements and extra vitamin B12, which will restore bone health and reduce risk of fractures.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey. nmbozkurt@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19151987

Citation

Bozkurt, Nuray, et al. "The Relationship of Homocyteine, B12 and Folic Acid With the Bone Mineral Density of the Femur and Lumbar Spine in Turkish Postmenopausal Women." Archives of Gynecology and Obstetrics, vol. 280, no. 3, 2009, pp. 381-7.
Bozkurt N, Erdem M, Yilmaz E, et al. The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women. Arch Gynecol Obstet. 2009;280(3):381-7.
Bozkurt, N., Erdem, M., Yilmaz, E., Erdem, A., Biri, A., Kubatova, A., & Bozkurt, M. (2009). The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women. Archives of Gynecology and Obstetrics, 280(3), 381-7. https://doi.org/10.1007/s00404-009-0936-0
Bozkurt N, et al. The Relationship of Homocyteine, B12 and Folic Acid With the Bone Mineral Density of the Femur and Lumbar Spine in Turkish Postmenopausal Women. Arch Gynecol Obstet. 2009;280(3):381-7. PubMed PMID: 19151987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women. AU - Bozkurt,Nuray, AU - Erdem,Mehmet, AU - Yilmaz,Ercan, AU - Erdem,Ahmet, AU - Biri,Aydan, AU - Kubatova,Ayca, AU - Bozkurt,Murat, Y1 - 2009/01/17/ PY - 2008/07/09/received PY - 2009/01/06/accepted PY - 2009/1/20/entrez PY - 2009/1/20/pubmed PY - 2009/10/7/medline SP - 381 EP - 7 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 280 IS - 3 N2 - OBJECTIVE: The relationship of homocyteine, B12 and folic acid with osteoporosis has already been studied in various populations. We compared the important factors in the metabolism of homocysteine, such as homocysteine, B12 and folic acid levels, of Turkish postmenopausal women, and their relationship with the femur and lumbar spine bone mineral density. METHODS: This cross-sectional study was conducted at Gazi University, Department of Obstetrics and Gynecology. The study group consisted of 178 postmenopausal women. Serum homocysteine, folic acid and Vitamin B12 were measured. BMD was measured using DEXA at the right femoral neck and lumbar spine (L1-L4). RESULTS: Upon evaluation of both the femur and lumbar spine, it was determined that osteoporosis could be associated with a homocysteine level above the median and with a B12 value under the lowest quintile value. CONCLUSION: Plasma Hcy and vitamin B12, but not folate levels, were associated with osteoporosis. Future interventional studies are needed to determine methods to reduce Hcy levels with dietary supplements and extra vitamin B12, which will restore bone health and reduce risk of fractures. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/19151987/The_relationship_of_homocyteine_B12_and_folic_acid_with_the_bone_mineral_density_of_the_femur_and_lumbar_spine_in_Turkish_postmenopausal_women_ L2 - https://dx.doi.org/10.1007/s00404-009-0936-0 DB - PRIME DP - Unbound Medicine ER -