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Endoscopic treatment of gastroesophageal varices in young infants with cyanoacrylate glue: a pilot study.
Gastrointest Endosc. 2009 May; 69(6):1034-8.GE

Abstract

BACKGROUND

In children, endoscopic sclerotherapy and variceal ligation (EVL) are the most used techniques for the treatment of gastroesophageal variceal bleeding (VB). However, these techniques achieve poor results in cases of gastric variceal bleeding, and EVL is not applicable in young infants.

OBJECTIVE

Our purpose was to evaluate the feasibility, efficacy, and safety of cyanoacrylate glue injection for the treatment of gastroesophageal varices in young infants.

DESIGN

Single-center prospective study.

PATIENTS

From 2001 to 2005, 8 young infants (<or=2 years old, <or=10 kg) with portal hypertension and gastroesophageal varices underwent treatment with N-butyl-2-cyanoacrylate.

MAIN OUTCOME MEASUREMENTS

Demographic data and the results were registered and analyzed at 1, 6, and 12 months after treatment.

RESULTS

The mean age and weight were 1.3 +/- 0.42 years (range 0.8 to 1.9 years) and 8.5 +/- 1.6 kg (range 5.5 to 10 kg). Glue injection was successfully performed in all infants. The mean volume injected was 1.15 +/- 0.62 mL (range 0.5 to 2 mL). Immediate control of bleeding was achieved in all cases. Ulcer bleeding as a complication was observed in 1 case. Varices relapse with bleeding was observed in 3 of 8 (37.5%) patients after a mean of 12.5 +/- 10.6 weeks (range 5 to 20 weeks). Patients with variceal rebleeding were retreated. Varices eradication was achieved in all cases after a mean of 1.4 +/- 0.52 sessions (range 1 to 2 sessions).

LIMITATIONS

Open prospective series with a relatively small number of patients.

CONCLUSION

In young infants, the use of cyanoacrylate glue is safe and effective for the treatment of gastroesophageal VB.

Authors+Show Affiliations

Department of Pediatrics, Division of Gastroenterology and Nutrition, Hôpital Edouard Herriot, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19152910

Citation

Rivet, Christine, et al. "Endoscopic Treatment of Gastroesophageal Varices in Young Infants With Cyanoacrylate Glue: a Pilot Study." Gastrointestinal Endoscopy, vol. 69, no. 6, 2009, pp. 1034-8.
Rivet C, Robles-Medranda C, Dumortier J, et al. Endoscopic treatment of gastroesophageal varices in young infants with cyanoacrylate glue: a pilot study. Gastrointest Endosc. 2009;69(6):1034-8.
Rivet, C., Robles-Medranda, C., Dumortier, J., Le Gall, C., Ponchon, T., & Lachaux, A. (2009). Endoscopic treatment of gastroesophageal varices in young infants with cyanoacrylate glue: a pilot study. Gastrointestinal Endoscopy, 69(6), 1034-8. https://doi.org/10.1016/j.gie.2008.07.025
Rivet C, et al. Endoscopic Treatment of Gastroesophageal Varices in Young Infants With Cyanoacrylate Glue: a Pilot Study. Gastrointest Endosc. 2009;69(6):1034-8. PubMed PMID: 19152910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoscopic treatment of gastroesophageal varices in young infants with cyanoacrylate glue: a pilot study. AU - Rivet,Christine, AU - Robles-Medranda,Carlos, AU - Dumortier,Jérôme, AU - Le Gall,Catherine, AU - Ponchon,Thierry, AU - Lachaux,Alain, Y1 - 2009/01/18/ PY - 2008/05/26/received PY - 2008/07/10/accepted PY - 2009/1/21/entrez PY - 2009/1/21/pubmed PY - 2009/8/7/medline SP - 1034 EP - 8 JF - Gastrointestinal endoscopy JO - Gastrointest Endosc VL - 69 IS - 6 N2 - BACKGROUND: In children, endoscopic sclerotherapy and variceal ligation (EVL) are the most used techniques for the treatment of gastroesophageal variceal bleeding (VB). However, these techniques achieve poor results in cases of gastric variceal bleeding, and EVL is not applicable in young infants. OBJECTIVE: Our purpose was to evaluate the feasibility, efficacy, and safety of cyanoacrylate glue injection for the treatment of gastroesophageal varices in young infants. DESIGN: Single-center prospective study. PATIENTS: From 2001 to 2005, 8 young infants (<or=2 years old, <or=10 kg) with portal hypertension and gastroesophageal varices underwent treatment with N-butyl-2-cyanoacrylate. MAIN OUTCOME MEASUREMENTS: Demographic data and the results were registered and analyzed at 1, 6, and 12 months after treatment. RESULTS: The mean age and weight were 1.3 +/- 0.42 years (range 0.8 to 1.9 years) and 8.5 +/- 1.6 kg (range 5.5 to 10 kg). Glue injection was successfully performed in all infants. The mean volume injected was 1.15 +/- 0.62 mL (range 0.5 to 2 mL). Immediate control of bleeding was achieved in all cases. Ulcer bleeding as a complication was observed in 1 case. Varices relapse with bleeding was observed in 3 of 8 (37.5%) patients after a mean of 12.5 +/- 10.6 weeks (range 5 to 20 weeks). Patients with variceal rebleeding were retreated. Varices eradication was achieved in all cases after a mean of 1.4 +/- 0.52 sessions (range 1 to 2 sessions). LIMITATIONS: Open prospective series with a relatively small number of patients. CONCLUSION: In young infants, the use of cyanoacrylate glue is safe and effective for the treatment of gastroesophageal VB. SN - 1097-6779 UR - https://www.unboundmedicine.com/medline/citation/19152910/Endoscopic_treatment_of_gastroesophageal_varices_in_young_infants_with_cyanoacrylate_glue:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(08)02273-6 DB - PRIME DP - Unbound Medicine ER -